全文获取类型
收费全文 | 2756篇 |
免费 | 320篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 127篇 |
妇产科学 | 42篇 |
基础医学 | 279篇 |
口腔科学 | 42篇 |
临床医学 | 315篇 |
内科学 | 661篇 |
皮肤病学 | 34篇 |
神经病学 | 288篇 |
特种医学 | 102篇 |
外科学 | 603篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 190篇 |
眼科学 | 49篇 |
药学 | 178篇 |
中国医学 | 1篇 |
肿瘤学 | 164篇 |
出版年
2022年 | 20篇 |
2021年 | 44篇 |
2020年 | 35篇 |
2019年 | 24篇 |
2018年 | 52篇 |
2017年 | 63篇 |
2016年 | 69篇 |
2015年 | 109篇 |
2014年 | 180篇 |
2013年 | 218篇 |
2012年 | 125篇 |
2011年 | 109篇 |
2010年 | 153篇 |
2009年 | 145篇 |
2008年 | 98篇 |
2007年 | 90篇 |
2006年 | 98篇 |
2005年 | 84篇 |
2004年 | 80篇 |
2003年 | 94篇 |
2002年 | 72篇 |
2001年 | 75篇 |
2000年 | 53篇 |
1999年 | 66篇 |
1998年 | 52篇 |
1997年 | 58篇 |
1996年 | 46篇 |
1995年 | 42篇 |
1994年 | 27篇 |
1993年 | 24篇 |
1992年 | 37篇 |
1991年 | 42篇 |
1990年 | 36篇 |
1989年 | 39篇 |
1988年 | 34篇 |
1987年 | 31篇 |
1986年 | 37篇 |
1985年 | 34篇 |
1984年 | 28篇 |
1983年 | 38篇 |
1982年 | 27篇 |
1980年 | 20篇 |
1979年 | 21篇 |
1978年 | 24篇 |
1977年 | 17篇 |
1976年 | 18篇 |
1975年 | 21篇 |
1973年 | 17篇 |
1972年 | 17篇 |
1971年 | 18篇 |
排序方式: 共有3122条查询结果,搜索用时 0 毫秒
61.
62.
Nakatsuji H Kishida K Funahashi T Shimomura I;Senri Study II Group 《Diabetes research and clinical practice》2012,95(3):e58-e60
We measured circulating S100A8/A9 (MRP8/14) complex levels before and after 3-month treatment with pioglitazone in type 2 diabetic patients. The results showed that pioglitazone reduced circulating S100A8/A9 complex levels, without changing body mass index, in type 2 diabetic patients with abdominal obesity. 相似文献
63.
64.
G. Yoon B. Baskin M. Tarnopolsky K. M. Boycott M. T. Geraghty E. Sell S. Goobie W. Meschino B. Banwell P. N. Ray 《Neurogenetics》2013,14(3-4):181-188
We describe the clinical and genetic features of a well-characterized cohort of patients with autosomal recessive hereditary spastic paraplegia (ARHSP) in the province of Ontario. Patients with documented corticospinal tract abnormalities were screened by whole gene sequencing and multiplex ligation probe amplification for mutations in nine genes known to cause ARHSP. Of a cohort of 39 patients, a genetic diagnosis was established in 17 (44 %) and heterozygous mutations were detected in 8 (21 %). Mutations were most frequent in SPG7 (12 patients), followed by SPG11 (10 patients), PNPLA6 (SPG39, 2 patients), and ZFYVE26 (SPG15, 2 patients). Although there are associations between some clinical manifestations of ARHSP and specific genes, many patients are tested at an early stage of the disease when phenotype/genotype correlations are not obvious. Accurate molecular characterization of well-phenotyped cohorts of patients will be essential to establishing the natural history of these rare degenerative disorders to enable future clinical trials. 相似文献
65.
Wesley E. Shankland II 《Cranio : the journal of craniomandibular practice》2013,31(4):269-278
Migraine and tension-type headaches have always plagued mankind. In spite of all the research dollars spent trying to determine the etiologies of these headaches, the neurology community still has not established a known cause of migraine and tension type headaches. This paper describes a study that was conducted for the U.S. Food and Drug Administration in which the efficacy of the Nociceptive Trigeminal Inhibition Tension Suppression System was evaluated and proved safe and efficacious in the reduction of medically diagnosed migraine and tension-type headache. 相似文献
66.
Wesley E. Shankland II 《Cranio : the journal of craniomandibular practice》2013,31(4):295-303
Jaw-deviation dystonia is characterized by the lateral shift of the mandible due to involuntary masticatory muscle contraction, causing difficulties in speech or mastication. We evaluated a patient with jaw-deviation dystonia by recording movement-related cortical potentials (MRCPs) and treated with muscle afferent block (MAB). MRCP associated with mandibular movements (mouth opening, closing, and left and right lateral movements) was recorded in the patient and ten age-matched healthy subjects. In the control subjects, the amplitude of Bereitschaftspotential (BP)/negative slope (NS') was significantly higher for left lateral movements than for the mouth closing. The cortical map of BP/NS' prior to mouth opening and closing showed symmetric distribution, whereas those of lateral movements showed a slight predominance in the ipsilateral hemisphere. The patient showed lower amplitude as compared with control subjects. The right lateral movement (homonymous task) showed task-specific markedly reduced potentials. After MAB by intramuscular injection of lidocaine and ethanol to the inferior head of the left lateral pterygoid muscle, the deviation abolished and severity in speech and mastication was significantly improved. This study suggests that jaw-deviation dystonia might have the same etiology as other focal dystonias. 相似文献
67.
K. Gulleroglu E. Baskin U.S. Bayrakci M. Aydogan F. Alehan A. Kantar F. Karakayali G. Moray M. Haberal 《Transplantation proceedings》2013,45(10):3511-3513
Neurocognitive dysfunction is one of the major complications of chronic renal failure (CRF). Uremic state during CRF encompasses a wide spectrum of neurobehavioral and neurological disturbances. Recent studies showed that the pathophysiology of neurocognitive dysfunction in CRF is related to plasma levels of uremic solutes. Successful renal transplantation improves renal, metabolic, and endocrine functions and the quality of life. The aim of our study was to determine the state of neurocognitive function in pediatric renal transplant recipients. We prospectively performed a neurological examination and neuropsychological test battery (Bender-Gestalt Test, Cancellation Test, and Visual and Auditory Number Assay Test) in 20 pediatric renal transplant recipients between 6 and 16 years of age. Twenty healthy children and 20 children with CRF were included in the study as the control groups. Mean age of the renal transplant recipients was 13.50 ± 3.40 years old. Mean evaluation time after transplantation was 2.0 ± 0.5 years. Bender-Gestalt Test result was abnormal in 40% of patients. The results of the Cancellation Test and the Visual and Auditory Number Assay Test showed significant decline in pediatric renal transplant patients when compared with the control. We found that neurocognitive dysfunction was frequent in pediatric renal transplantation patients. Awareness of this potential problem may be helpful for early recognition and treatment. Our findings suggest that periodic neurocognitive assessments may be indicated in transplant recipients. 相似文献
68.
M. R. Allen N. X. Chen V. H. Gattone II X. Chen A. J. Carr P. LeBlanc D. Brown S. M. Moe 《Osteoporosis international》2013,24(4):1471-1481
Summary
Bisphosphonates reduce skeletal loss and fracture risk, but their use has been limited in patients with chronic kidney disease. This study shows skeletal benefits of zoledronic acid in an animal model of chronic kidney disease.Introduction
Bisphosphonates are routinely used to reduce fractures but limited data exists concerning their efficacy in non-dialysis chronic kidney disease. The goal of this study was to test the hypothesis that zoledronic acid produces similar skeletal effects in normal animals and those with kidney disease.Methods
At 25 weeks of age, normal rats were treated with a single dose of saline vehicle or 100 μg/kg of zoledronic acid while animals with kidney disease (approximately 30 % of normal kidney function) were treated with vehicle, low dose (20 μg/kg), or high dose (100 μg/kg) zoledronic acid, or calcium gluconate (3 % in the drinking water). Skeletal properties were assessed 5 weeks later using micro-computed tomography, dynamic histomorphometry, and mechanical testing.Results
Animals with kidney disease had significantly higher trabecular bone remodeling compared to normal animals. Zoledronic acid significantly suppressed remodeling in both normal and diseased animals yet the remodeling response to zoledronic acid was no different in normal and animals with kidney disease. Animals with kidney disease had significantly lower cortical bone biomechanical properties; these were partially normalized by treatment.Conclusions
Based on these results, we conclude that zoledronic acid produces similar amounts of remodeling suppression in animals with high turnover kidney disease as it does in normal animals, and has positive effects on select biomechanical properties that are similar in normal animals and those with chronic kidney disease. 相似文献69.
Esra Baskin Arda Saygili Koray Harmanci Pinar Isik Agras F. Nurhan Özdemir Sükrü Mercan 《Renal failure》2013,35(5):557-560
Acute renal failure (ARF) is a major complication in infants who undergo cardiac surgery. The aim of this investigation was to identify possible risk factors for ARF and mortality in this patients group. Out of 64 patients, 21 (32.8%) cases developed acute renal failure and overall mortality rate was 25%. The mortality rate was higher in the infants who developed ARF than those who did not (66.7% and 4.7%, respectively, p < 0.05). Also, ARF was positively correlated with mortality (r:0.70, p < 0.0001). The nonsurvivors had lower mean serum albumin than did the survivors (p < 0.05), and serum albumin level was negatively correlated with mortality (r = ? 0.34, p < 0.05). For the patients with serum albumin level < 3.5 g/dL, the unadjusted odds ratio for mortality was 4.3 (CI 95%:1.05 ? 17.86). Total bypass time and aorta clamping time were significantly longer in the nonsurvivor group than in the survivor group (p < 0.05 for both). In conclusion, the significant risk factors for mortality in these patients were development of ARF, low serum albumin level, and long total bypass and aorta clamping times, which may be predictive of poor prognosis. 相似文献
70.
Howard I. Pryor II Adam Singleton Elissa Lin Paul Lin Khashayar Vaziri 《Surgical endoscopy》2013,27(3):843-848