Coping style and women's participation in breast and gynecological screening

The purpose of this project was to determine the role of coping style in women's practice of breast and gynecological screening behaviors. Women were classified into one of four coping groups based on measures of vigilance and screening distress. Data were analyzed from a subset of 85 U.S. women who participated in a larger longitudinal study designed to examine self-reported screening participation. Results indicate frequency of screening participation and importance of obtaining immediate mammography feedback differed across coping style groups. Women characterized as high in vigilance and screening distress were most at risk for nonparticipation in screening.     

Cloacogenic Carcinoma: A Study of Six Cases and Review of Literature

A clinicopathological study of six cases of cloacogenic carcinoma and review of the literature was undertaken. These tumors arise from transitional epithelium of the pectinate line. The tumors are often deceptive in the beginning and may often resemble small abscesses, fissures, or fistulas. Often they appear outside the mucosa and skin. Histologically, they are well, moderately, or poorly differentiated. Local excision is adequate for small noninfiltrating tumors. Pelvic radiation, combined with surgery for lesions greater than 2 cm with local extension and/or pelvic nodes, controls the pelvic disease. Well and moderately differentiated tumors have a better prognosis than squamous cell carcinoma. Overall survival rate is approximately 50%. Cure rate depends on the size of the lesion, differentiation of tumor, depth of invasion, duration of the symptoms, nodal involvement, lymphatic or vascular invasion, and contiguous organ invasion. Cloacogenic carcinoma is a better term than other names used in the literature for this tumor.     

Diaphragmatic paralysis in motor neuron disease. Report of two cases and a review of the literature

Two patients presenting with respiratory insufficiency had diaphragmatic paralysis secondary to adult-onset motor neuron disease (progressive spinal muscular atrophy). A review of the literature discloses seven similar cases, most of them reported in non-neurological journals.     

A modular microfluidic architecture for integrated biochemical analysis

Microfluidic laboratory-on-a-chip (LOC) systems based on a modular architecture are presented. The architecture is conceptualized on two levels: a single-chip level and a multiple-chip module (MCM) system level. At the individual chip level, a multilayer approach segregates components belonging to two fundamental categories: passive fluidic components (channels and reaction chambers) and active electromechanical control structures (sensors and actuators). This distinction is explicitly made to simplify the development process and minimize cost. Components belonging to these two categories are built separately on different physical layers and can communicate fluidically via cross-layer interconnects. The chip that hosts the electromechanical control structures is called the microfluidic breadboard (FBB). A single LOC module is constructed by attaching a chip comprised of a custom arrangement of fluid routing channels and reactors (passive chip) to the FBB. Many different LOC functions can be achieved by using different passive chips on an FBB with a standard resource configuration. Multiple modules can be interconnected to form a larger LOC system (MCM level). We demonstrated the utility of this architecture by developing systems for two separate biochemical applications: one for detection of protein markers of cancer and another for detection of metal ions. In the first case, free prostate-specific antigen was detected at 500 aM concentration by using a nanoparticle-based bio-bar-code protocol on a parallel MCM system. In the second case, we used a DNAzyme-based biosensor to identify the presence of Pb(2+) (lead) at a sensitivity of 500 nM in <1 nl of solution.     

Maturity status of youth football players: a noninvasive estimate

PURPOSE: To estimate the biological maturity status of youth football players 9-14 yr old using a noninvasive method and to compare the body size of players of contrasting status. METHODS: Subjects were members of youth football teams in two central Michigan communities. Height and weight were measured on 653 boys 8.7-14.6 yr. Heights of biological parents of 582 boys were reported and subsequently adjusted for overestimation. Decimal age, height, and weight of the player and midparent height were used to predict mature (adult) height for the boy. Current height of each player was expressed as a percentage of his predicted mature height to provide an estimate of biological maturity status. Percentage of predicted mature height of each boy was expressed as a z-score to classify players into maturity groups. ANCOVA, controlling for age, was used to compare body size in contrasting maturity groups. RESULTS: Mean percentages of predicted mature height of the players matched those of longitudinal reference samples, but there was a trend for higher percentages among older players, suggesting advanced maturation. Overall, 405 boys were classified as on time/average in maturity status (69.6% [95%CI 65.7-73.3]), 154 were classified as early/advanced (25.5% [95%CI 23.0-30.3]), and only 23 were classified as late/delayed (3.9% [95%CI 2.6-6.0]). The gradient for height, weight, and BMI was as follows: early > on time > late, and differences were greater for weight and the BMI than for height. CONCLUSION: Percentage of predicted mature height attained at a given age appears to be a reasonable indicator of maturity status. The method needs to be validated with other more direct indicators (skeletal age, sexual maturation) and applied to other samples.