Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

Background  

The purpose of this study was to compare the expression and the prognostic effect of the breast cancer stem cell marker aldehyde dehydrogenase-1 (ALDH1) in young and elderly breast cancer patients.     

Prostatic evaluation by transrectal sonography: criteria for diagnosis of early carcinoma

Over a 7-month period, from a total of 417 transrectal ultrasound (US) studies, 45 transperineal biopsies of the prostate were performed in the radiology department. Transrectal US guidance and local anesthesia were used. Twenty-two of 32 hypoechoic lesions, located within the peripheral zone tissue of the gland, were proved by histologic study to be cancerous. Hyperechoic lesions were all histologically benign hyperplasias. The patients experienced no major complications necessitating hospitalization or increased length of hospital stay as a result of the procedure.     

Complications of intravenous DSA performed for carotid artery disease: a prospective study

One hundred and two patients, who were being evaluated for carotid artery disease, were prospectively studied for complications occurring as a result of intravenous digital subtraction angiography (DSA). We recorded the type, number, and outcome of complications and reviewed the amount of contrast material used, along with the patient's age and medical history for possible correlation with increased complications. There were 55 total complications or side effects involving 37 patients. Central nervous system (CNS) complications included six major-transient and one major-permanent complication. Systemic complications included 20 major-transient and two major-permanent events. The patient's age and the amount of contrast material used did not appear to be significant risk factors. Complications in our series were significantly higher than previous DSA reports and published data on conventional angiography studies. Many of our patients were in a relatively high risk group, including 74 patients who had multisystem disease and 30 who had histories of angina.     

Antianxiety and antidepressant effects of riparin III from Aniba riparia (Nees) Mez (Lauraceae) in mice

This work presents behavioral effects of methyl ethers of N-(2,6-dihydroxybenzoyl) tyramine (riparin III) isolated from the unripe fruit of Aniba riparia on the open field, elevated plus maze (EPM), rotarod, hole board, barbiturate-induced sleeping time, tail suspension and forced swimming tests in mice. Riparin III was administered intraperitoneally to male mice at single doses of 25 and 50 mg/kg. The results showed that riparin III with both doses had no effects on spontaneous motor activity in mice or in the rotarod test, but decreased the number of grooming and rearing. At the dose of 50 mg/kg, riparin III increased the number of entries in the open arms of the EPM test as compared with control. Similarly, in the hole-board test, both doses increased the number of head dips. There was a reduction on the sleeping latency with both doses and a prolongation of the pentobarbital-induced sleeping time with the dose of 25 mg/kg. In the tail suspension test, similar to imipramine (30 mg/kg), riparin III at the dose of 50 mg/kg presented a reduction in the immobility time. In the forced swimming test, both doses of riparin III decreased the immobility time. These results showed that riparin III potentiated the barbiturate-induced sleeping time and presented antidepressant- and anxiolytic-like effects.     

Colonization pressure: a critical parameter in the epidemiology of antibiotic-resistant bacteria

ABSTRACT: The recognition of colonization pressure as an important risk factor for acquisition of antibiotic-resistant bacteria in the ICU, including Acinetobacter species, has major consequences for our understanding of risk factor analyses. Moreover, the importance of colonization pressure underpins the role of cross-transmission in the dynamics of antibiotic-resistant bacteria in the ICU, which has major consequences for the evaluation of the effectiveness of infection control measures.