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851.
852.
853.
Behfar M Sarrafzadeh-Rezaei F Hobbenaghi R Delirezh N Dalir-Naghadeh B 《中华创伤杂志(英文版)》2011,14(6):329-335
Objective:To evaluate the potential effects of uncultured adipose-derived stromal vascular fraction on tendon healing.Methods:Twenty five adult male New Zealand white rabbits weighing 2.5-3.0 kg were used.Five rabbits were used as donors of adipose tissue and the rest were divided into control and treatment groups.The injury model was completed by unilateral tenotomy through the middle one third of deep digital flexor tendon.Immediately after suture repair,either fresh stromal vascular fraction from enzymatic digestion of adipose tissue or placebo was intratendinously injected at tendon stumps in treatment and control groups,respectively.Immobilization with cast was continued for two weeks after surgery.Animals were sacrificed at eight weeks after surgery and tendons underwent histological,immunohistochemical,and mechanical evaluations.Statistical analyses of quantitative and qualitative data were assessed using one-way analysis of variance and MannWhitney U-test,respectively.Results:Histological evaluations demonstrated superior fibrillar linearity and continuity,and decreased vascularity in treatment group indicated improved organization and remodeling of neotendons.Immunohistochemistry demonstrated a significant increase in collagen I expression in treatment group.Ultimate load and energy absorption capacity were both significantly increased in cell-treated repairs compared with controls.Conclusion: The present study shows that intratendinous injection of uncultured adipose-derived stromal vascular fraction results in improved structural and mechanical properties of tendon repairs and it could be an effective modality for treating tendon injury. 相似文献
854.
Jan C. Buckner Bahram Forouzesh Manuel Hidalgo Joseph P. Boni Gary Dukart Anna Berkenblit Eric K. Rowinsky 《Investigational new drugs》2010,28(3):334-342
An oral formulation of temsirolimus (Torisel?), an inhibitor of the mammalian target of rapamycin, was evaluated on an intermittent
schedule (once daily for 5 days every 2 weeks) in patients with advanced cancer. The maximum tolerated dose was determined
to be 75 mg after dose-limiting toxicities of grade 3 elevated aminotransferases (1 patient) and grade 3 rash (1 patient)
occurred with a 100-mg dose. The most common temsirolimus-related adverse events were mucositis, rash/maculopapular rash,
and asthenia. Six of 12 patients who received the 75-mg dose required dose reductions due to temsirolimus-related adverse
events. Two patients who received 75-mg temsirolimus and did not have dose reductions had minor tumor responses. Relative
exposure from contributions of both temsirolimus and sirolimus, the principal metabolite, was 17.9% of the 75-mg dose. Thus,
oral temsirolimus, 75 mg administered once daily for 5 days every 2 weeks, was further evaluated in patients with metastatic
breast cancer. 相似文献
855.
856.
Corticosteroid-responsive encephalopathy associated with autoimmune thyroiditis (also called Hashimoto's encephalopathy) is a rare, life-threatening, treatable, and possibly autoimmune condition. We identified nine patients (with the diagnosis made after 1979) who had relapsing encephalopathy compatible with previous reports of Hashimoto's encephalopathy and no other identifiable cause of encephalopathy at Mayo Clinic Rochester. Of these nine patients, three were clinically hypothyroid, four were subclinically hypothyroid, and two were euthyroid. Thyroid antibodies were positive in eight of eight patients in whom these measurements were made. Electroencephalographic abnormalities were identified in eight of the nine patients (89%). Magnetic resonance imaging (MRI) abnormalities considered etiologically related to encephalopathy were present in three patients (33%). An increased protein concentration was noted on cerebrospinal fluid examination in seven patients (78%). Of the six patients who received high-dose glucocorticoid therapy, 5 (83%) had improvement of neurologic symptoms. In conclusion, encephalopathy associated with autoimmune thyroiditis is rare but important to recognize because it may be responsive to high-dose glucocorticoid therapy. We believe that this condition is not caused by thyroid dysfunction or antithyroid antibodies but represents an association of an uncommon autoimmune encephalopathy with a common autoimmune thyroid disease. The term Hashimoto's encephalopathy is a misnomer and should not be used. 相似文献
857.
Gholam A. Peyman Bahram Khoobehi Saeed Shamsnia Greta C. Navarro 《Lasers in surgery and medicine》1993,13(6):680-684
We modified a scanning laser ophthalmoscope for simultaneous photocoagulation of the retina and video recording. Using a diode laser (810 nm wavelength), we produced fundus lesions that scarred within 14 days. © 1993 Wiley-Liss, Inc. 相似文献
858.
Bahram Mokri Bruce R Krueger Gary M Miller David G Piepgras 《Journal of neuroimaging》1993,3(1):11-15
Three patients with headaches in erect but not recumbent positions had barely measurable cerebrospinal fluid (CSF) pressures and aseptic but abnormal CSF findings with variable pleocytosis and elevated protein content. The CSF glucose level was normal and there were no blasts or malignant cells. Gadolinium-enhanced magnetic resonance imaging (MRI) in all 3 showed diffuse meningeal enhancement. In 2, headaches and MRI abnormalities completely resolved spontaneously. The third patient, who had a prior ventriculoperitoneal shunt, improved after shunt revision. 相似文献
859.
MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism 总被引:6,自引:0,他引:6
K. Goto M. Ota S. Ohno N. Mizuki H. Ando Y. Katsuyama W. P. Maksymowych M. Kimura S. Bahram H. Inoko 《Tissue antigens》1997,49(5):503-507
In order to address the possibility that the MICA gene located 47 kb upstream from HLA-B is involved in the pathogenesis of ankylosing spondylitis (AS), we have investigated microsatellite polymorphism in the transmembrane region of MICA in Caucasian patients with AS. The microsatellite allele consisting of 4 repetitions of GCT/AGC was present at significantly higher frequency in the patient group (Pc<0.0000001) than in the ethnically matched control group. However, the frequency of the (GCT/AGC)4 allele was significantly low in the B27-positive patients than in the B27-positive healthy controls (Pc=0.0145). These observations suggest that B27 itself remains the primary genetic marker for AS, although the significantly dissimilar pheno-type frequency of the (GCT/AGC)4 allele in B27-positive patients and healthy individuals may reflect the existence of other genetic factor(s) in the HLA-B27 haplotype involved in the development of AS. 相似文献
860.
Dr. Masoud Soheilian MD Dr. Mohammad Mazareei MD Bahram Rahman MD Hamid Ahmadieh MD Mohsen Azarmina MD Mohammad H. Dehghan MD Arman Mashayekhi MD Shahin Yazdani MD Siamak Moradian MD 《Annals of Ophthalmology》2005,37(4):253-258
In 82 eyes with complex retinal detachment requiring internal tamponade, 53 were filled with 5000-cs and 29 with 1000-cs silicone
oil. Use of high-viscosity silicone oil (5000 cs) may be associated with a poorer anatomic and functional outcome compared
with lower viscosity silicone oil (1000 cs). 相似文献