The effects of radiofrequency catheter ablation on the metabolic enzymes and Ca++-ATPase of myocytes

Summary Using histochemical technique, the effects of radiofrequency catheter ablation (RFCA) on the activities of LDH, SDH, CCO, and Ca⁺⁺-ATPase of guinea-pig ventricular myocytes were examined. The histological changes were observed for comparison. Radiofrequency energy (500 kHz) delivered was 20 WX 10 s. The results were as follows: RFCA resulted in significant impairments in all the four kinds of enzymes but without statistical differences in the areas involved in this energy level. No statistically significant difference was found between the ranges of enzymatic damages and areas of pathological lesions. These findings showed a consistency in areas of the histological and histochemical lesions resulted from RFCA.     

Parametric phase-delay estimation of sound transmitted through intact human lung

Sonic noise between 300 and 1600 Hz is introduced into the mouths of 11 healthy adult male subjects at resting lung volume and is detected over the anterior extrathoracic trachea and at three sites on the right posterior chest wall. To overcome the difficulties associated with non-parametric phase unwrapping due to thoracic anti-resonances, the pahse delay τ(f) of propagation between the trachea and the chest wall is estimated using a linear parametric ARX-type statistical model with the non-parametric magnitude spectra as a guide. The resulting τ(f) estimates are unambiguous and reliable, and show a clear trend of decreasing τ(f) with increasing frequency, indicating that sound at higher frequencies reaches the chest wall faster than that at lower frequencies. This finding indicates that respiratory sound transmission is highly dispersive, most probably owing to frequencydependent airway and parenchymal wavespeeds.     

Maternal corneal thickness during pregnancy

We measured central corneal thickness in 89 pregnant women. It was increased 16 micron (P = .01) compared to the control eyes of 18 nongravid and 17 postpartum women. There was no significant difference (P = .79) in corneal thickness between the nongravid and postpartum groups. When comparing subjects by week of gestation, there was no trend over time in corneal thickness (analysis by linear regression). Intraocular pressure was lowered during pregnancy, but it did not correlate with corneal thickness for either the pregnant or nonpregnant group.     

小肝癌的病理与螺旋CT诊断

原发性肝癌(primaryhepatocellularcarcinoma,PH CC)在我国是居第3位的恶性肿瘤,每年患者达11万之多,预后甚差[1]。肝癌的早期诊断,是提高患者5年生存率的重要手段,也是影像学面临的重大课题。直径>3cm的病灶,各种影像学技术的检出敏感性均很高,无统计学差异。而对于小肝癌(SHCC),特别是微小肝癌(MHCC)的检出仍有一定困难,其检出敏感性有一定差异。以往文献报道术中超声、CT动脉门脉造影(CTAP)和碘油CT的敏感性最高,但均为创伤性检查,临床应用有严格指征。1989年螺旋CT机问世,其连续快速扫描和容积数据采集成像技术的应用,特别是近…     

组织多肽特异性抗原在乳腺癌中的临床研究

OBJECTIVE: To investigate the expression of serum tissue polypeptide-specific antigen (TPS) in breast cancer patients and its clinical value in such cases. METHODS: Altogether 160 subjects (90 patients with breast cancer, 40 with benign breast lesions, and 30 healthy subjects) were enrolled in this study. The serum TPS and CA153 levels were measured by ELISA in all the subjects. RESULTS: The levels and positivity rate of serum TPS and CA153 in breast cancer group were significantly higher than those in the normal subjects group and benign lesion group (P<0.01), and became even higher as the malignancy progressed. High serum TPS level was detected in the cancer patients in stage I. Serum TPS level was the most sensitive to bone metastasis of the malignancy, but its highest levels occurred in cases of lymphoid node metastasis (P<0.05). In patients who responded favorably to the treatment, serum TPS and CA153 levels were significantly reduced (P<0.05), but the reduction in TPS levels tended to be more obvious (P<0.05). CONCLUSION: Serum TPS can be used as a very useful and sensitive tumor marker in the diagnosis of breast cancer, especially in case of bone metastasis, and may be of great value in clinical decision-making and assessment of therapeutic effect.     

孟鲁斯特对哮喘模型IL-5mRNA和IL-5蛋白表达的影响

目的 探讨白三烯受体拮抗剂孟鲁斯特(MK)对哮喘小鼠IL-5mRNA、IL-5蛋白表达的影响。方法 采用原位杂交、免疫组化LSAB法,检测哮喘小鼠及孟鲁斯特治疗后哮喘小鼠骨髓细胞IL-5mRNA的表达及肺、骨髓、脾IL-5蛋白的表达情况。 结果 孟鲁斯特可显著减轻哮喘小鼠肺组织炎症细胞浸润、细支气管痉挛、粘液分泌等;亦可减少骨髓IL-5mRNA阳性细胞数(P<0.02),并使骨髓、肺、脾IL-5蛋白表达下降。 结论 白三烯受体拮抗剂孟鲁斯特不仅使肺部炎症显著减轻,也抑制骨髓细胞表达IL-5mRNA、IL-5蛋白,提示白三烯可能通过调节炎症细胞、细胞因子合成来应答过敏原反应。