全文获取类型
收费全文 | 2511篇 |
免费 | 222篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 53篇 |
妇产科学 | 32篇 |
基础医学 | 451篇 |
口腔科学 | 82篇 |
临床医学 | 282篇 |
内科学 | 505篇 |
皮肤病学 | 48篇 |
神经病学 | 203篇 |
特种医学 | 87篇 |
外科学 | 310篇 |
综合类 | 4篇 |
预防医学 | 216篇 |
眼科学 | 20篇 |
药学 | 168篇 |
中国医学 | 7篇 |
肿瘤学 | 244篇 |
出版年
2024年 | 6篇 |
2023年 | 34篇 |
2022年 | 31篇 |
2021年 | 85篇 |
2020年 | 59篇 |
2019年 | 85篇 |
2018年 | 171篇 |
2017年 | 94篇 |
2016年 | 114篇 |
2015年 | 127篇 |
2014年 | 122篇 |
2013年 | 186篇 |
2012年 | 297篇 |
2011年 | 306篇 |
2010年 | 108篇 |
2009年 | 85篇 |
2008年 | 187篇 |
2007年 | 161篇 |
2006年 | 141篇 |
2005年 | 115篇 |
2004年 | 77篇 |
2003年 | 46篇 |
2002年 | 45篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 6篇 |
1971年 | 5篇 |
1970年 | 1篇 |
1923年 | 1篇 |
排序方式: 共有2740条查询结果,搜索用时 16 毫秒
21.
Aurélie Baldolli Marie Chuffart Loik Geffray Laurence Verneuil Oumédaly Reman 《Bulletin du cancer》2013,100(4):317-321
We describe three cases of intravascular lymphoma B with different clinical presentation: one case of a cutaneous variant and two cases with surrenal and cutaneous localisation. All patients are in complete remission after chemotherapy alone or after chemotherapy and autologous stem cells transplantation. The review of the literature as well as our cases specify the interest of an aggressive chemotherapy with autologous of peripheral stem cells if it was possible. 相似文献
22.
23.
24.
25.
Frédéric Carrière Philippe Grandval Christophe Renou Aurélie Palomba Florence Priéri Jacqueline Giallo Friederike Henniges Suntje Sander-Struckmeier René Laugier 《Clinical gastroenterology and hepatology》2005,3(1):28-38
BACKGROUND & AIMS: The contribution of human gastric lipase (HGL) to the overall lipolysis process in chronic pancreatitis (CP), as well as the relative pancreatic enzyme levels, rarely are addressed. This study was designed to quantify pancreatic and extrapancreatic enzyme output, activity, and stability in CP patients vs. healthy volunteers. METHODS: Healthy volunteers (n = 6), mild CP patients (n = 5), and severe (n = 7) CP patients were intubated with gastric and duodenal tubes before the administration of a test meal. HGL, human pancreatic lipase (HPL), chymotrypsin, and amylase concentrations were assessed in gastric and duodenal samples by measuring the respective enzymatic activities. Intragastric and overall lipolysis levels at the angle of Treitz were estimated based on quantitative analysis of lipolysis products. Similar analyses were performed on duodenal contents incubated ex vivo for studying enzyme stability and evolution of lipolysis. RESULTS: Although HPL, chymotrypsin, and amylase outputs all were extremely low, HGL outputs in patients with severe CP (46.8 +/- 31.0 mg) were 3-4-fold higher than in healthy controls (13.3 +/- 13.8 mg). Intragastric lipolysis did not increase, however, in patients with severe CP, probably because of the rapid decrease in the pH level of the gastric contents caused by a higher gastric acid secretion. HGL remains active and highly stable in the acidic duodenal contents of CP patients, and, overall, can achieve a significant lipolysis of the dietary triglycerides (30% of the control values) in the absence of HPL. CONCLUSIONS: Although all pancreatic enzyme secretions are simultaneously reduced in severe CP, gastric lipase can compensate partly for the loss of pancreatic lipase but not normalize overall lipolytic activity. 相似文献
26.
Maxence Meyer MD Lidia Calabrese MD Anita Meyer MD Florentin Constancias PhD Louise F. Porter MD PhD Marion Muller Manon Leitner Amandine Leitner Antonin Michaud Georges Kaltenbach MD PhD Elise Schmitt MD PhD Patrick Karcher MD Erik Sauleau MD PhD Saïd Chayer PhD HDR Floriane Zeyons MD Marianne Riou MD Soraya El Ghannudi Abdo MD Frédéric Blanc MD PhD Samira Fafi-Kremer PharmD PhD Aurélie Velay PharmD PhD Thomas Vogel MD PhD 《Journal of the American Geriatrics Society》2021,69(5):1167-1170
27.
28.
Jean-Marc?Le?Goff Claire?Roger Benjamin?Louart Pierre?Géraud?Claret Aurélien?Daurat Stéphanie?Bulyez Jean-Yves?LefrantEmail author Xavier?Bobbia Laurent?Muller 《Journal of clinical monitoring and computing》2018,32(3):513-518
Lung ultrasound (LUS) increases clinical diagnosis performance in intensive care unit (ICU). Real-time three-dimensional (3-D) imaging was compared with two-dimensional (2-D) LUS by assessing the global diagnosis concordance. In this single center, prospective, observational, pilot study, one trained operator performed a 3-D LUS immediately after a 2-D LUS in eight areas of interest on the same areas in 16 ventilated critically ill patients. All cine loops were recorded on a computer without visible link between 2-D and 3-D exams. Two experts blindly reviewed cine loops. Four main diagnoses were proposed: normal lung, consolidation, pleural effusion and interstitial syndrome. Fleiss κ and Cohen’s κ values were calculated. In 252 LUS cine loops, the concordance between 2-D and 3-D exams was 83.3% (105/126), 77.6% (99/126) and 80.2% (101/126) for the trained operator and the experts respectively. The Cohen’s κ coefficient value was 0.69 [95% Confidence Interval (CI) 0.58–0.80] for expert 1 meaning a substantial agreement. The inter-rater reliability was very good (Fleiss’ κ value?=?0.94 [95% CI 0.87–1.0]) for 3-D exams. The Cohen’s κ was excellent for pleural effusion (κ=?0.93 [95% CI 0.76–1.0]), substantial for normal lung diagnosis (κ?=?0.68 [95% CI 0.51–0.86]) and interstitial syndrome (κ?=?0.62 [95% CI 0.45–0.80]) and fair for consolidation diagnoses (κ?=?0.47 [95% CI 0.30–0.64]). In ICU ventilated patients, there was a substantial concordance between 2-D and 3-D LUS with a good inter-rater reliability. However, the diagnosis concordance for lung consolidation is poor. 相似文献
29.
30.
Elsa Balleydier Guillaume Camuset Cristina Socolovschi Marie-Pierre Moiton Barbara Kuli Aurélie Foucher Patrice Poubeau Gianandrea Borgherini Guillaume Wartel Héla Audin Didier Raoult Laurent Filleul Philippe Parola Fréderic Pagès 《Emerging infectious diseases》2015,21(2):316-319
Murine typhus case was initially identified in Reunion, France, in 2012 in a tourist. Our investigation confirmed 8 autochthonous cases that occurred during January 2011–January 2013 in Reunion. Murine typhus should be considered in local patients and in travelers returning from Reunion who have fevers of unknown origin. 相似文献