全文获取类型
收费全文 | 2948篇 |
免费 | 152篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 28篇 |
妇产科学 | 33篇 |
基础医学 | 413篇 |
口腔科学 | 129篇 |
临床医学 | 169篇 |
内科学 | 883篇 |
皮肤病学 | 57篇 |
神经病学 | 214篇 |
特种医学 | 87篇 |
外科学 | 340篇 |
综合类 | 8篇 |
一般理论 | 1篇 |
预防医学 | 92篇 |
眼科学 | 52篇 |
药学 | 324篇 |
中国医学 | 12篇 |
肿瘤学 | 265篇 |
出版年
2023年 | 27篇 |
2022年 | 42篇 |
2021年 | 67篇 |
2020年 | 42篇 |
2019年 | 52篇 |
2018年 | 59篇 |
2017年 | 49篇 |
2016年 | 58篇 |
2015年 | 52篇 |
2014年 | 77篇 |
2013年 | 96篇 |
2012年 | 190篇 |
2011年 | 169篇 |
2010年 | 86篇 |
2009年 | 76篇 |
2008年 | 141篇 |
2007年 | 145篇 |
2006年 | 129篇 |
2005年 | 140篇 |
2004年 | 120篇 |
2003年 | 113篇 |
2002年 | 137篇 |
2001年 | 90篇 |
2000年 | 108篇 |
1999年 | 93篇 |
1998年 | 28篇 |
1997年 | 22篇 |
1996年 | 20篇 |
1995年 | 15篇 |
1994年 | 13篇 |
1993年 | 15篇 |
1992年 | 67篇 |
1991年 | 62篇 |
1990年 | 73篇 |
1989年 | 38篇 |
1988年 | 41篇 |
1987年 | 51篇 |
1986年 | 32篇 |
1985年 | 40篇 |
1984年 | 34篇 |
1983年 | 17篇 |
1981年 | 11篇 |
1979年 | 26篇 |
1977年 | 13篇 |
1976年 | 13篇 |
1975年 | 21篇 |
1974年 | 11篇 |
1973年 | 10篇 |
1971年 | 11篇 |
1969年 | 13篇 |
排序方式: 共有3114条查询结果,搜索用时 15 毫秒
61.
Severe exacerbation of hepatitis after short-term corticosteroid therapy in a patients with "latent" chronic hepatitis B 总被引:2,自引:0,他引:2
Shiota G Harada K Oyama K Udagawa A Nomi T Tanaka K Tsutsumi A Noguchi N Kishimoto Y Horie Y Suou T Kawasaki H 《Liver》2000,20(5):415-420
We present a case of severe exacerbation of hepatitis after short-term corticosteroid therapy for chronic inflammatory demyelinating polyneuropathy (CIPD) with "latent" chronic hepatitis B showing no HBV-related antigens and antibodies. After corticosteroid pulse therapy for CIPD, the patient had severe exacerbation of hepatitis twice. Although she did not show any hepatitis B virus (HBV)-related antigens or antibodies, sequences of HBV were detected in serum and liver by a nested polymerase chain reaction. A sequence analysis of HBV at the second exacerbation showed that the G-to-A point mutation at nucleotide 1896 that converted codon 28 from tryptophan (TGG) to a stop codon (TAG) in the precore region resulted in amino acid change, which has been frequently observed in fulminant hepatitis and severe hepatitis in Japan. 相似文献
62.
63.
Low-dose ethanol attenuates gut ischemia/reperfusion-induced liver injury in rats via nitric oxide production 总被引:2,自引:0,他引:2
Horie Y Yamagishi Y Kato S Kajihara M Kimura H Ishii H 《Journal of gastroenterology and hepatology》2003,18(2):211-217
BACKGROUND AND AIMS: The acute administration of low-dose ethanol was demonstrated to attenuate liver injury elicited by gut ischemia/reperfusion (I/R). Nitric oxide (NO) has been found to be a modulator of adhesive interactions between leukocytes, platelets, and endothelial cells, but there has been much controversy about the effects of ethanol on NO regulation. The objective of this study was to investigate the role of NO in ethanol-reduced hepatic microvascular dysfunction elicited by gut I/R. METHODS: Male Wistar rats were exposed to 30 min of gut ischemia followed by 60 min of reperfusion. Intravital microscopy was used to monitor leukocyte recruitment and non-perfused sinusoids (NPS). Plasma alanine aminotransferase (ALT) activities were measured 6 h after the onset of reperfusion. In another set of experiments, ethanol (10%, 1 g/kg) was administered before ischemia. RESULTS: Gut I/R elicited increases in the number of stationary leukocytes, NPS, and plasma ALT activities; all of which were attenuated by pretreatment with ethanol or an NO donor. Gut I/R caused the apoptosis of hepatocytes, which was prevented by pretreatment with ethanol. Pretreatment with an NO synthase inhibitor diminished the protective effects of ethanol. The administration of ethanol increased plasma nitrite/nitrate levels. CONCLUSION: These results suggest that low-dose ethanol attenuates the gut I/R-induced hepatic microvascular dysfunction and sequential liver injury by increasing sinusoidal NO levels. 相似文献
64.
Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative colitis 总被引:10,自引:0,他引:10
Yukawa M Iizuka M Horie Y Yoneyama K Shirasaka T Itou H Komatsu M Fukushima T Watanabe S 《International journal of colorectal disease》2002,17(2):70-76
BACKGROUND AND AIMS: Recent studies suggest that Fas-mediated apoptosis is involved in the pathogenesis of inflammatory bowel disease (IBD). This study was conducted to clarify whether soluble forms of Fas (sFas) and Fas ligand (sFasL) are concerned with inflammation in IBD. METHODS AND PATIENTS: Concentration of serum sFas and sFasL was measured by enzyme-linked immunosorbent assay in 10 patients with ulcerative colitis (UC), 10 with Crohn's disease (CD) in both active and remission stages, and 20 controls. Expression of Fas and sFas in colonic mucosa was examined by western blot. Distribution of Fas and FasL in colonic mucosa was examined by immunohistochemistry in 20 UC, 20 CD, and 10 non-IBD colitis patients and in 10 controls. Apoptotic cells were examined by TUNEL. RESULTS: Concentration of systemic sFas was significantly lower in active UC than controls. The number of FasL-containing cells was significantly higher in active UC than in remission UC, non-IBD colitis, and controls. Apoptotic cells were increased in active UC. CONCLUSIONS: Our results demonstrate that systemic and local Fas-mediated apoptosis is promoted in UC, which might be involved in the pathogenesis in UC. 相似文献
65.
Goshi Shiota Ken‐ichi Harada Kenji Oyama Akihide Udagawa Takahiro Nomi Kiwamu Tanaka Atsushi Tsutsumi Naoya Noguchi Yosuke Kishimoto Yutaka Horie Takeaki Suou Hironaka Kawasaki 《Liver international》2000,20(5):415-420
Abstract: We present a case of severe exacerbation of hepatitis after short‐term corticosteroid therapy for chronic inflammatory demyelinating polyneuropathy (CIPD) with “latent” chronic hepatitis B showing no HBV‐related antigens and antibodies. After corticosteroid pulse therapy for CIPD, the patient had severe exacerbation of hepatitis twice. Although she did not show any hepatitis B virus (HBV)‐related antigens or antibodies, sequences of HBV were detected in serum and liver by a nested polymerase chain reaction. A sequence analysis of HBV at the second exacerbation showed that the G‐to‐A point mutation at nucleotide 1896 that converted codon 28 from tryptophan (TGG) to a stop codon (TAG) in the precore region resulted in amino acid change, which has been frequently observed in fulminant hepatitis and severe hepatitis in Japan. 相似文献
66.
Christiane Bergamasco RD Lilian Mika Horie RD Raquel Susana Torrinhas BD Dan L. Waitzberg MD PhD 《JPEN. Journal of parenteral and enteral nutrition》2015,39(8):941-947
Background: The daily consumption of dietary fiber is frequently below suggested recommendations. Using a double‐blind, controlled, randomized study, we assessed the efficiency and tolerance of a fiber‐enriched orange juice to supplement fiber intake in women. Materials and Methods: After 1 week of noninterventional observation, 192 healthy adult women ingested 400 mL of orange juice for 21 days, which either was not (placebo group) or was enriched with fiber (fiber group). Orange juice ingestion was registered daily and controlled for each week during the study period. Macronutrient, fiber, and energy intake were determined using a 3‐day food record, validated food chemical composition databases, and the “Pro Diet” software. Gastrointestinal symptoms were self‐evaluated daily by scoring 4 grades of symptom intensity and using a visual analog scale to grade pain severity. Results: No changes were observed for macronutrient and energy ingestion. For the placebo group (n = 97), the total fiber intake record was under the daily recommended value. In contrast, the fiber group (n = 95) displayed higher comparative values of total and soluble fiber consumption (P ≤ .001), achieving the daily recommended values of fiber intake. Both groups reported an increased frequency of slight bloating and rumbles over time (P ≤ .05). The fiber group also experienced a higher frequency of slight flatulence over time (P = .002). Conclusion: Consumption of fiber‐enriched orange juice was efficient to achieve the daily fiber intake recommendation for women, was not accompanied by intense adverse events, and may represent a suitable method to supplement fiber intake in woman. 相似文献
67.
68.
69.
Toko Maehara Kenjiro Matsumoto Kazuhide Horiguchi Makoto Kondo Satoshi Iino Shunji Horie Takahisa Murata Hirokazu Tsubone Shoichi Shimada Hiroshi Ozaki Masatoshi Hori 《British journal of pharmacology》2015,172(4):1136-1147
Background and Purpose
Post-operative ileus (POI) is induced by intestinal inflammation. Here, we aimed to clarify the effects of 5-HT3 receptor antagonists against POI.Experimental Approach
We administered three 5-HT3 receptor antagonists, ondansetron, tropisetron and palonosetron, to a mouse model of POI induced by surgical intestinal manipulation (IM). Immunohistochemistry, intestinal transit, inflammatory mediator mRNA expression and 5-HT content were measured. In some experiments, 5-HT3A receptor null mice were used.Key Results
Three 5-HT3 receptor antagonists reduced IM-induced infiltration of inflammatory CD68-positive macrophages and myeloperoxidase-stained neutrophils. Ondansetron exhibited no anti-inflammatory actions in 5-HT3A receptor null mice. Ondansetron inhibited expression of the chemokine CCL2, IL-1β, IL-6, TNF-α and iNOS mRNAs up-regulated by IM, and also ameliorated the delayed gastrointestinal transit. Peritoneal macrophages, but not most infiltrating monocyte-derived macrophages, expressed 5-HT3 receptors. IM stimulation increased the 5-HT content of peritoneal lavage fluid, which up-regulated mRNA expression of proinflammatory cytokines in peritoneal macrophages. Immunohistochemical localization of 5-HT3 receptors suggests that ondansetron suppressed expression of these mRNAs in activated peritoneal macrophages, adhering to the serosal region of the inflamed intestinal wall.Conclusion and Implications
5-HT3 receptor antagonists were anti-inflammatory, mainly targeting peritoneal macrophages expressing these receptors. They also restored the delayed gastrointestinal transit by IM. 5-HT3 receptor antagonists should be therapeutically useful agents against POI. 相似文献70.
Keiichiro Watanabe Ariunzaya Bat-Erdene Hirofumi Tenshin Qu Cui Jumpei Teramachi Masahiro Hiasa Asuka Oda Takeshi Harada Hirokazu Miki Kimiko Sogabe Masahiro Oura Ryohei Sumitani Yukari Mitsui Itsuro Endo Eiji Tanaka Makoto Kawatani Hiroyuki Osada Toshio Matsumoto Masahiro Abe 《Haematologica》2021,106(4):1172