Retraction Note to: Cerebrospinal fluid ferritin in glioblastoma: evidence for tumor synthesis

Journal of Neuro-Oncology - Given its rare incidence, there are few epidemiological case series on paraneoplastic neurologic syndromes (PNS). We present a 10-year series compiled in the Section of...     

Fabrication of Self‐Healable Hydrogels through Sol–Gel Transition in Metallo‐supramolecular Aqueous Solution by Aeration

A sol–gel transition and the self‐healing of the resultant hydrogels are achieved utilizing a metallo‐supramolecule composed of terpyridine‐terminated low‐molecular‐weight three‐armed poly(ethylene glycol) (trisPEGtpy₄₅₀) in water at ambient temperature. The gelation of trisPEGtpy₄₅₀ with cobalt ions occurs by aerobic oxidation (mild conditions), and therefore the solution can be moulded into any shape hydrogel. The solation of the cured hydrogels occurs spontaneously upon the addition of the reductant, and the solution is then re‐gelled by exposure to air due to the consumption of the reductant. Both a sol–gel transition by aeration and self‐healing of the resultant hydrogels without any stimuli are observed when replacing some of the cobalt ions with nickel ions.

     

Multiple cytochrome P-450 subfamilies are co-induced with P-glycoprotein by both phenothiazine and 2-acetylaminofluorene in rats.

We studied the effects of two P-glycoprotein (P-gp) inducers, 2-acetylaminofluorene (2-AAF) and phenothiazine (PTZ), administered intraperitoneally, on the activities and content of hepatic cytochrome P-450 (CYP) subfamilies in hepatic microsomes of Sprague-Dawley rats. After 4-day administration of 2-AAF or PTZ, the P-gp content was increased. The total CYP content after PTZ treatment was significantly increased compared with that of controls. The CYP1A, CYP2B and CYP3A2 contents were induced, while the CYP2C6, CYP2C11 and CYP2E1 contents remained unaffected. A marked increase in CYP1A1 was found after administration of each compound. Ethoxyresorufin O-deethylase, pentoxyresorufin O-deethylase, and testosterone 6beta hydroxylation activities showed a significant increase after both 2-AAF and PTZ treatments. In particular, ethoxyresorufin O-deethylase exhibited more than ten times greater activity than that of the controls after the treatments. These results suggest that P-gp inducers affect several CYP subfamilies in addition to CYP3A, which is reported to be up-regulated coordinately with P-gp by a CYP3A inducer.