CD10 expression in tumour and stromal cells of bladder carcinoma: an association with bilharziasis

CD10 is a cell surface zinc metalloprotease expressed in a variety of normal cell types, including lymphoid precursor cells, germinal centre B lymphocytes and some epithelial cells. The aim of this study was to assess the prognostic value of CD10 in bladder carcinoma. The expression of CD10 was immunohistochemically assessed in 49 cases of primary bladder carcinoma in comparison with 10 non-neoplastic normal bladder mucosa specimens. 27 cases (55%) were tumour CD10(+) and tumour CD10 positivity was significantly correlated with advanced stage, larger tumor size, and shorter mean survival time. Extensive tumoral staining assessed by H score further documented the positive correlation of CD10 with worse prognostic factors in the whole group and its subdivisions (SCC and TCC), in addition to its significant association with bilharziasis in SCC. Only CD10-tumour positivity in the whole group proved to be an independent prognostic factor for overall survival by multivariate analysis. No significant value of stromal CD10 expression in the investigated bladder carcinoma cases was found. This study points to the prognostic value of neoplastic CD10 expression in bladder carcinoma and its possible importance in facilitating tumour invasion and metastasis. Bilharziasis could have a role in upregulation of CD10 expression in SCC.     

Prognostic impact of toll-like receptors 2 and 4 expression on monocytes in Egyptian patients with hepatocellular carcinoma

Immunologic Research - Toll-like receptors (TLRs) have a role in chronic inflammation. Still, little is known about the expression of TLRs in hepatocellular carcinoma (HCC). Herein, we tried to...     

Natural Killer and Natural Killer T Cells in Juvenile Systemic Lupus Erythematosus: Relation to Disease Activity and Progression

Archivum Immunologiae et Therapiae Experimentalis - The contribution of innate immune cells, including natural killer (NK) and natural killer T (NKT) cells, in systemic lupus erythematosus (SLE) is...     

Inhibition of Basal and Stimulated Gastric Acid Secretion by an Enkephalin Analogue

The effect of a synthetic enkephalin analogue (Sandoz FF33-824; DAMME) on basal and submaximally stimulated gastric acid secretion was investigated in six healthy hypersecretors. Basal acid secretion was markedly inhibited by the enkephalin analogue. When gastric secretion was stimulated by a continuous intravenous infusion of 100 ng/kg/h of pentagastrin the enkephalin analogue reduced acid output by 50%. Intravenous naloxone reversed the subjective effects of the enkephalin analogue but did not reverse the inhibitory effect on basal and stimulated acid secretion.     

Possible role of rice bran extract in microglial modulation through PPAR-gamma receptors in alzheimer’s disease mice model

Metabolic Brain Disease - Alzheimer's Disease (AD), the most prevalent neurodegenerative disorder among elderly people, is ordinarily associated with progressive cognitive decline. Peroxisome...