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IntroductionTwo patients (one with neurofibromatosis type 1) presented with unilateral ocular pulsation.MethodsA CT scan of the orbits revealed extensive dysgenesis of the orbital roof with herniation of the frontal lobe into the orbit in both cases. PASCAL dynamic contour tonometry was performed.ResultsThe ipsilateral ocular pulse amplitude (OPA) was greater than the contralateral side, and the ocular pulse waveform morphology more closely approximated the known intracranial waveform in these patients.ConclusionsWe hypothesize that the greater OPA was due to stronger transmission of the intracranial pressure waveform amplitude and morphology in the absence of the orbital roof.Key Words: Ocular pulse amplitude, Cerebrospinal fluid pulse, Sphenoid wing dysplasia, Orbital roof dysgenesis, Intracranial pressure  相似文献   
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Oocyte-donation is generally safe but may exacerbate psychiatric symptoms in some women. In this prospective study 63 oocyte-donating women and, as a control group, 63 women providing their own oocytes for in vitro fertilization (in couples with male infertility) were evaluated pre- and post-ovulation-induction in regard to hypochondriasis, anxiety, social impairment, and depression. The mean hypochondriasis score for oocyte-donators was significantly lower than for women providing their own oocytes, prior to ovulation-induction (5.03 vs. 6.59). However, after ovulation-induction and oocyte retrieval this score rose to 6.66 among oocyte-donators, whereas it remained essentially unchanged among women providing their own oocytes (6.66). The mean anxiety score for oocyte-donating women also rose following this procedure, from 5.87 to 7.65. Depression scores for both groups remained similar, before and after the procedure. Results showed that at the beginning of the ARP donating women have the same conditions as own oocyte women regarding depression and anxiety but after the egg harvesting they would suffer more damages regarding hypochondriasis and anxiety aspects.  相似文献   
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Bulletin of Environmental Contamination and Toxicology - With increasing urbanization and industrialization, clean air is becoming a scarce resource. During the present investigation,...  相似文献   
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949.

Introduction

The optimal concentration for the use of endodontic topical antibiotics is not known. The aims of this study were to determine the minimum bactericidal concentrations (MBCs) and minimum inhibitory concentrations (MICs) of metronidazole, ciprofloxacin, minocycline, Augmentin (GlaxoSmithKline, Research Triangle Park, NC), and tigecycline against common endodontic pathogens and to evaluate ex vivo the antibacterial efficacy and discoloration effect of triple antibiotic paste (TAP), Augmentin, and tigecycline at different concentrations using a slow-release hydrogel scaffold.

Methods

Using the Epsilometer test method (Etest; bioMérieux USA, St Louis, MO), MICs and MBCs of selected antibiotics were determined against Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus intermedius, and Enterococcus faecalis. Biofilms of these bacterial species were then grown in extracted single-rooted teeth anaerobically for 3 weeks. Root canals were filled with TAP, Augmentin, and tigecycline at concentrations of 1 or 0.1 mg/mL in a degradable hydrogel scaffold or pure TAP at 1 g/mL for 7 days. Coronal discoloration was evaluated spectrophotometrically at 1, 2, and 3 weeks after dressing.

Results

MIC/MBC data showed significant efficacy of tigecycline, Augmentin, and minocycline compared with the other antibiotics (P < .05). Significant differences were found when comparing the log10 colony-forming units of all experimental groups (P < .05). TAP at 1 g/mL had no bacterial growth but caused the greatest discoloration. Hydrogel mixtures with TAP, Augmentin, or tigecycline at 1 mg/mL significantly reduced bacterial growth and the number of positive samples compared with those at 0.1 mg/mL (P < .05) with minimal discoloration.

Conclusions

TAP, Augmentin, and tigecycline in a hydrogel at 1 mg/mL reduced bacterial growth significantly with minimal color change.  相似文献   
950.

Introduction

The purpose of this systematic review was to determine whether endodontic infections had an impact on the pathogenesis of systemic disease.

Methods

Two reviewers independently conducted a comprehensive literature search. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies, gray literature of all relevant articles, and textbooks were manually searched. There was no disagreement between the 2 reviewers.

Results

Four articles met the inclusion criteria with a high risk of bias. Three articles were analyzed for quantitative synthesis. All these articles were regarding cardiovascular disease (CVD). There was low-certainty evidence that a lesion of endodontic origin can contribute to systemic disease, 95% confidence interval, risk ratio 1.2 (0.79–1.83). Owing to high heterogeneity among the studies, sub-group analysis was undertaken. The results reported more consistent outcome with risk ratio 0.95 (0.75–1.21) and low certainty. Therefore, the authors have limited confidence in the effect estimate, which indicates that the true effect may be substantially different from the estimate of the effect.

Conclusions

Whether the presence of a lesion of endodontic origin may or may not have some impact on cardiovascular disease, the level of evidence is low, and our confidence in the assessment is low. This systematic review raised questions in the designs and analysis of the data, and further well-conducted longitudinal research would be required to make this causality claim.  相似文献   
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