全文获取类型
收费全文 | 3817篇 |
免费 | 230篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 189篇 |
妇产科学 | 139篇 |
基础医学 | 432篇 |
口腔科学 | 162篇 |
临床医学 | 357篇 |
内科学 | 814篇 |
皮肤病学 | 40篇 |
神经病学 | 123篇 |
特种医学 | 87篇 |
外科学 | 807篇 |
综合类 | 88篇 |
一般理论 | 2篇 |
预防医学 | 197篇 |
眼科学 | 90篇 |
药学 | 270篇 |
中国医学 | 31篇 |
肿瘤学 | 223篇 |
出版年
2023年 | 37篇 |
2022年 | 99篇 |
2021年 | 131篇 |
2020年 | 105篇 |
2019年 | 128篇 |
2018年 | 155篇 |
2017年 | 103篇 |
2016年 | 121篇 |
2015年 | 129篇 |
2014年 | 168篇 |
2013年 | 215篇 |
2012年 | 311篇 |
2011年 | 313篇 |
2010年 | 163篇 |
2009年 | 141篇 |
2008年 | 235篇 |
2007年 | 215篇 |
2006年 | 195篇 |
2005年 | 210篇 |
2004年 | 185篇 |
2003年 | 153篇 |
2002年 | 135篇 |
2001年 | 54篇 |
2000年 | 45篇 |
1999年 | 46篇 |
1998年 | 29篇 |
1997年 | 24篇 |
1996年 | 17篇 |
1995年 | 16篇 |
1994年 | 16篇 |
1993年 | 10篇 |
1992年 | 13篇 |
1991年 | 13篇 |
1990年 | 14篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 15篇 |
1985年 | 14篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1979年 | 4篇 |
1978年 | 9篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1972年 | 3篇 |
1969年 | 4篇 |
1965年 | 3篇 |
排序方式: 共有4081条查询结果,搜索用时 9 毫秒
41.
Tahereh Ashraf Ganjooei Zanbagh Pirastehfar Asieh Mosallanejad Masoomeh Raoufi Noushin Afshar Moghaddam Mozhgan Hashemieh 《Clinical Case Reports》2022,10(7)
Swyer syndrome is a 46, XY karyotype, with pure gonadal dysgenesis and primary amenorrhea. These females have primordial Mullerian structures and seek medical attention as they experience primary amenorrhea. Here, we report a 15‐year‐old girl, diagnosed as Swyer syndrome associated with left ovarian dysgerminoma. 相似文献
42.
Albert Dahan Eveline van Dorp Terry Smith Ashraf Yassen 《European Journal of Pain》2008,12(4):403-411
Morphine‐6‐glucuronide (M6G) is morphine's active metabolite acting at the μ‐opioid receptor. Recent experimental human studies and 5 of 6 randomized clinical trials indicate that M6G causes adequate and long lasting pain relief comparable to morphine. There are various observations that M6G is associated with a reduction in the severity of side effects normally associated with opioid use, such as reduced postoperative nausea and vomiting (PONV) and reduced respiratory depression. The present drug profile provides a review of the pharmacological properties of M6G, the clinical evidence relating to its efficacy and safety, and discusses its future role in the treatment of postoperative pain. 相似文献
43.
Hani Z. Asfour Nabil A. Alhakamy Osama A. A. Ahmed Usama A. Fahmy Shadab Md Mohamed A. El-Moselhy Waleed Y. Rizg Adel F. Alghaith Basma G. Eid Ashraf B. Abdel-Naim 《Drug delivery》2022,29(1):1892
The present study aimed to design and optimize, a nanoconjugate of gabapentin (GPN)-melittin (MLT) and to evaluate its healing activity in rat diabetic wounds. To explore the wound healing potency of GPN-MLT nanoconjugate, an in vivo study was carried out. Diabetic rats were subjected to excision wounds and received daily topical treatment with conventional formulations of GPN, MLT, GPN-MLT nanoconjugate and a marketed formula. The outcome of the in vivo study showed an expedited wound contraction in GPN-MLT-treated animals. This was confirmed histologically. The nanoconjugate formula exhibited antioxidant activities as evidenced by preventing malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymatic exhaustion. Further, the nanoconjugate showed superior anti-inflammatory activity as it inhibited the expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). This is in addition to enhancement of proliferation as indicated by increased expression of transforming growth factor-β (TGF- β), vascular endothelial growth factor-A (VEGF-A) and platelet-derived growth factor receptor-β (PDGFRB). Also, nanoconjugate enhanced hydroxyproline concentration and mRNA expression of collagen type 1 alpha 1 (Col 1A1). In conclusion, a GPN-MLT nanoconjugate was optimized with respect to particle size. Analysis of pharmacokinetic attributes showed the mean particle size of optimized nanoconjugate as 156.9 nm. The nanoconjugate exhibited potent wound healing activities in diabetic rats. This, at least partly, involve enhanced antioxidant, anti-inflammatory, proliferative and pro-collagen activities. This may help to develop novel formulae that could accelerate wound healing in diabetes. 相似文献
44.
Anood Alassaf Khaled Ellithy Tejas Mehta Walid Aljbawi Hossamaldein Ali Ashraf Soliman Mohammed Al Amri Abdulqadir J. Nashwan 《Clinical Case Reports》2022,10(8)
Our patient is a 3‐week‐old female neonate, presented with complaints of low‐grade fever and a congested nose for one day. Eventually, she developed progressive desaturation, hypotension, and poor perfusion due to severe pulmonary hemorrhage. Then, she developed cardiac arrest and was declared dead. 相似文献
45.
46.
Ashraf Kamour David James David J. Lupton Gillian Cooper Micheal Eddleston Allister Vale 《Clinical toxicology (Philadelphia, Pa.)》2014,52(10):1025-1031
Objective. To characterise the patterns of presentation and clinical features of toxicity following reported recreational use of benzofuran compounds ((2-aminopropyl)-2,3-dihydrobenzofurans) in the UK, as reported to the National Poisons Information Service (NPIS), and to compare clinical features of toxicity with those after reported mephedrone use. Methods. NPIS patient-specific telephone enquiries and user sessions for TOXBASE®, the NPIS online information database, related to (2-aminopropyl)-2,3-dihydrobenzofurans and associated synonyms were reviewed from March 2009 to August 2013. These data were compared with those of mephedrone, the recreational substance most frequently reported to NPIS, collected over the same period. Results. There were 63 telephone enquiries concerning 66 patients and 806 TOXBASE® user sessions regarding benzofuran compounds during the period of study. The first telephone enquiry was made in July 2010 and the highest numbers of enquiries were received in August 2010 (33 calls, 112 TOXBASE® sessions). Patients were predominantly male (82%) with a median age of 29 years; 9 reported co-ingestion of other substances. Comparing the 57 patients who reported ingesting benzofuran compounds alone with 315 patients ingesting mephedrone alone, benzofurans were more often associated with stimulant features, including tachycardia, hypertension, mydriasis, palpitation, fever, increased sweating, and tremor, (72% vs. 38%, odds ratio [OR] 4.2, 95% confidence interval [CI] 2.27–7.85, P < 0.0001) and mental health disturbances (58% vs. 38%, OR 2.3, 95% CI 1.29–4.07, P = 0.006). Other features reported after benzofuran compound ingestion included gastrointestinal symptoms (16%), reduced level of consciousness (9%), chest pain (7%), and creatinine kinase elevation (5%). Conclusions. Reported ingestion of benzofuran compounds is associated with similar toxic effects to those of amphetamines and cathinones. Mental health disturbances and stimulant features were reported more frequently following reported ingestion of benzofuran compounds than after ingestion of mephedrone. 相似文献
47.
Ahmed A. Mourad Gehan H. Heeba Ashraf Taye Mohamed A. El‐Moselhy 《Fundamental & clinical pharmacology》2013,27(5):489-497
Obesity is often associated with chronic inflammatory state which contributes to the development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). This study investigated the effects of single and combined administration of atorvastatin (ATOR, lipid‐lowering drug) and losartan (LOS, angiotensin receptor antagonist) on metabolic disorders and inflammatory status that are implicated in the development of T2DM with the use of pioglitazone (PIO) as a standard antidiabetic drug. T2DM was induced in male rats by high‐fat diet (HFD) feeding for 16 weeks. Oral administrations of ATOR (10 mg/kg), LOS (20 mg/kg), PIO (3 mg/kg), their binary combinations, or vehicle were started in the last 4 weeks. Fasting serum glucose, oral glucose tolerance, fasting serum insulin, IR, serum lipid profile, serum TNF‐α and body composition index were determined. Results showed that all drugs and their combinations had positive impact effect on all measured parameters, and better results were achieved from binary drug combinations than administration of each drug alone. Combination of PIO with either ATOR or LOS provided better improvements on T2DM‐associated metabolic abnormalities and inflammatory status with respect to each drug alone. However, the most pronounced effects of drugs and their combinations regarding the above parameters were attributed to LOS + PIO combination. In conclusion, this study indicates that combination of ATOR + PIO and, in particular, LOS + PIO can be used as promising effective therapies in the management of HFD‐induced T2DM. This concept may be attributed to the combined effects of the respective monotherapies to improve lipid profile, insulin sensitivity, and TNF‐α level. 相似文献
48.
49.
50.