全文获取类型
收费全文 | 781篇 |
免费 | 39篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 39篇 |
妇产科学 | 12篇 |
基础医学 | 69篇 |
口腔科学 | 9篇 |
临床医学 | 58篇 |
内科学 | 197篇 |
皮肤病学 | 3篇 |
神经病学 | 6篇 |
特种医学 | 314篇 |
外科学 | 28篇 |
综合类 | 14篇 |
预防医学 | 24篇 |
眼科学 | 3篇 |
药学 | 46篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2022年 | 1篇 |
2021年 | 11篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 10篇 |
2017年 | 1篇 |
2016年 | 5篇 |
2015年 | 9篇 |
2014年 | 5篇 |
2013年 | 10篇 |
2012年 | 6篇 |
2011年 | 7篇 |
2010年 | 14篇 |
2009年 | 18篇 |
2008年 | 8篇 |
2007年 | 30篇 |
2006年 | 8篇 |
2005年 | 9篇 |
2004年 | 4篇 |
2003年 | 8篇 |
2002年 | 11篇 |
2001年 | 11篇 |
2000年 | 10篇 |
1999年 | 12篇 |
1998年 | 46篇 |
1997年 | 40篇 |
1996年 | 57篇 |
1995年 | 45篇 |
1994年 | 33篇 |
1993年 | 38篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 11篇 |
1989年 | 33篇 |
1988年 | 36篇 |
1987年 | 30篇 |
1986年 | 26篇 |
1985年 | 40篇 |
1984年 | 20篇 |
1983年 | 23篇 |
1982年 | 26篇 |
1981年 | 24篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 26篇 |
1976年 | 18篇 |
1975年 | 15篇 |
1969年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有842条查询结果,搜索用时 9 毫秒
61.
62.
63.
Mobile apps for chemistry in the world of drug discovery 总被引:1,自引:0,他引:1
Mobile hardware and software technology continues to evolve very rapidly and presents drug discovery scientists with new platforms for accessing data and performing data analysis. Smartphones and tablet computers can now be used to perform many of the operations previously addressed by laptops or desktop computers. Although the smaller screen sizes and requirements for touch-screen manipulation can present user-interface design challenges, especially with chemistry-related applications, these limitations are driving innovative solutions. In this early review of the topic, we collectively present our diverse experiences as software developer, chemistry database expert and na?ve user, in terms of what mobile platforms could provide to the drug discovery chemist in the way of applications in the future as this disruptive technology takes off. 相似文献
64.
Oral Diseases (2010) 16 , 221–232 Practitioners of oral medicine frequently encounter patients with complaints of taste disturbance. While some such complaints represent pathological processes specific to the gustatory system, per se, this is rarely the case. Unless taste‐bud mediated qualities such as sweet, sour, bitter, salty, umami, chalky, or metallic are involved, ‘taste’ dysfunction inevitably reflects damage to the sense of smell. Such ‘taste’ sensations as chicken, chocolate, coffee, raspberry, steak sauce, pizza, and hamburger are dependent upon stimulation of the olfactory receptors via the nasopharynx during deglutition. In this paper, we briefly review the anatomy, physiology, and pathophysiology of the olfactory system, along with means for clinically assessing its function. The prevalence, etiology, and nature of olfactory disorders commonly encountered in the dental clinic are addressed, along with approaches to therapy and patient management. 相似文献
65.
66.
67.
68.
Studeny S Cheppudira BP Meyers S Balestreire EM Apodaca G Birder LA Braas KM Waschek JA May V Vizzard MA 《Journal of molecular neuroscience : MN》2008,36(1-3):175-187
Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide widely distributed in neural pathways that regulate micturition. VIP is also an endogenous anti-inflammatory agent that has been suggested for the development of therapies for inflammatory disorders. In the present study, we examined urinary bladder function and hindpaw and pelvic sensitivity in VIP(-/-) and littermate wildtype (WT) controls. We demonstrated increased bladder mass and fewer but larger urine spots on filter paper in VIP(-/-) mice. Using cystometry in conscious, unrestrained mice, VIP(-/-) mice exhibited increased void volumes and shorter intercontraction intervals with continuous intravesical infusion of saline. No differences in transepithelial resistance or water permeability were demonstrated between VIP(-/-) and WT mice; however, an increase in urea permeability was demonstrated in VIP(-/-) mice. With the induction of bladder inflammation by acute administration of cyclophosphamide, an exaggerated or prolonged bladder hyperreflexia and hindpaw and pelvic sensitivity were demonstrated in VIP(-/-) mice. The changes in bladder hyperreflexia and somatic sensitivity in VIP(-/-) mice may reflect increased expression of neurotrophins and/or proinflammatory cytokines in the urinary bladder. Thus, these changes may further regulate the neural control of micturition. 相似文献
69.
There has been recent increased interest in utilizing motivational interviewing (MI) to increase adolescent readiness to quit smoking, but attempts to impact quit rates have thus far been discouraging. A better understanding of factors associated with adolescent readiness to quit smoking prior to receiving any intervention may provide guidance when tailoring future MI interventions in order to increase their effectiveness with this population. Adolescent smokers (N=191) who had been admitted to a psychiatric hospital and enrolled in a clinical trial evaluating MI completed questionnaires that assessed smoking behavior and variables thought to be related to smoking. Confidence to quit smoking and negative beliefs about smoking were significant predictors of adolescents' baseline readiness to quit smoking. The failure to demonstrate relationships between health consequences and readiness suggest that caution may be warranted in the use of feedback, a common component of MI-based interventions. Such feedback tends to focus on health consequences, which was unrelated to adolescent baseline readiness to change smoking behavior in the current study. Parallels between current results and the Theory of Planned Behavior are discussed in consideration of developing more effective MI-based interventions for adolescent smokers. 相似文献
70.
Biological evaluation of intervertebral disc cells in different formulations of gellan gum‐based hydrogels 下载免费PDF全文
G Khang SK Lee HN Kim J Silva‐Correia ME Gomes CAA Viegas IR Dias JM Oliveira RL Reis 《Journal of tissue engineering and regenerative medicine》2015,9(3):265-275
Gellan gum (GG)‐based hydrogels are advantageous in tissue engineering not only due to their ability to retain large quantities of water and provide a similar environment to that of natural extracellular matrix (ECM), but also because they can gelify in situ in seconds. Their mechanical properties can be fine‐tuned to mimic natural tissues such as the nucleus pulposus (NP). This study produced different formulations of GG hydrogels by mixing varying amounts of methacrylated (GG‐MA) and high‐acyl gellan gums (HA‐GG) for applications as acellular and cellular NP substitutes. The hydrogels were physicochemically characterized by dynamic mechanical analysis. Degradation and swelling abilities were assessed by soaking in a phosphate buffered saline solution for up to 170 h. Results showed that as HA‐GG content increased, the modulus of the hydrogels decreased. Moreover, increases in HA‐GG content induced greater weight loss in the GG‐MA/HA‐GG formulation compared to GG‐MA hydrogel. Potential cytotoxicity of the hydrogel was assessed by culturing rabbit NP cells up to 7 days. An MTS assay was performed by seeding rabbit NP cells onto the surface of 3D hydrogel disc formulations. Viability of rabbit NP cells encapsulated within the different hydrogel formulations was also evaluated by Calcein‐AM and ATP assays. Results showed that tunable GG‐MA/HA‐GG hydrogels were non‐cytotoxic and supported viability of rabbit NP cells. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献