全文获取类型
收费全文 | 7977篇 |
免费 | 414篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 128篇 |
儿科学 | 410篇 |
妇产科学 | 207篇 |
基础医学 | 833篇 |
口腔科学 | 184篇 |
临床医学 | 661篇 |
内科学 | 1785篇 |
皮肤病学 | 144篇 |
神经病学 | 573篇 |
特种医学 | 247篇 |
外科学 | 1558篇 |
综合类 | 167篇 |
一般理论 | 3篇 |
预防医学 | 366篇 |
眼科学 | 178篇 |
药学 | 497篇 |
中国医学 | 71篇 |
肿瘤学 | 414篇 |
出版年
2023年 | 67篇 |
2022年 | 208篇 |
2021年 | 318篇 |
2020年 | 191篇 |
2019年 | 220篇 |
2018年 | 263篇 |
2017年 | 172篇 |
2016年 | 222篇 |
2015年 | 243篇 |
2014年 | 346篇 |
2013年 | 482篇 |
2012年 | 614篇 |
2011年 | 619篇 |
2010年 | 355篇 |
2009年 | 292篇 |
2008年 | 462篇 |
2007年 | 505篇 |
2006年 | 493篇 |
2005年 | 442篇 |
2004年 | 405篇 |
2003年 | 349篇 |
2002年 | 291篇 |
2001年 | 98篇 |
2000年 | 82篇 |
1999年 | 67篇 |
1998年 | 37篇 |
1997年 | 22篇 |
1996年 | 31篇 |
1995年 | 37篇 |
1994年 | 30篇 |
1993年 | 30篇 |
1992年 | 46篇 |
1991年 | 50篇 |
1990年 | 28篇 |
1989年 | 43篇 |
1988年 | 29篇 |
1987年 | 21篇 |
1986年 | 24篇 |
1985年 | 20篇 |
1984年 | 18篇 |
1983年 | 15篇 |
1982年 | 8篇 |
1981年 | 21篇 |
1980年 | 16篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1977年 | 10篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1967年 | 12篇 |
排序方式: 共有8426条查询结果,搜索用时 15 毫秒
101.
PPAR‐gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double‐blind randomized controlled pilot trial
下载免费PDF全文
![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
102.
Paola Bianchi Elisa Fermo Kimberly Lezon-Geyda Eduard J. van Beers Holmes D. Morton Wilma Barcellini Bertil Glader Satheesh Chonat Yaddanapudi Ravindranath Peter E. Newburger Nina Kollmar Jenny M. Despotovic Madeleine Verhovsek Mukta Sharma Janet L. Kwiatkowski Kevin H. M. Kuo Marcin W. Wlodarski Hassan M. Yaish Susanne Holzhauer Heng Wang Joachim Kunz Kathryn Addonizio Hasan Al-Sayegh Wendy B. London Oliver Andres Richard van Wijk Patrick G. Gallagher Rachael F. F. Grace 《American journal of hematology》2020,95(5):472-482
Pyruvate kinase (PK) deficiency is a rare recessive congenital hemolytic anemia caused by mutations in the PKLR gene. This study reports the molecular features of 257 patients enrolled in the PKD Natural History Study. Of the 127 different pathogenic variants detected, 84 were missense and 43 non-missense, including 20 stop-gain, 11 affecting splicing, five large deletions, four in-frame indels, and three promoter variants. Within the 177 unrelated patients, 35 were homozygous and 142 compound heterozygous (77 for two missense, 48 for one missense and one non-missense, and 17 for two non-missense variants); the two most frequent mutations were p.R510Q in 23% and p.R486W in 9% of mutated alleles. Fifty-five (21%) patients were found to have at least one previously unreported variant with 45 newly described mutations. Patients with two non-missense mutations had lower hemoglobin levels, higher numbers of lifetime transfusions, and higher rates of complications including iron overload, extramedullary hematopoiesis, and pulmonary hypertension. Rare severe complications, including lower extremity ulcerations and hepatic failure, were seen more frequently in patients with non-missense mutations or with missense mutations characterized by severe protein instability. The PKLR genotype did not correlate with the frequency of complications in utero or in the newborn period. With ICCs ranging from 0.4 to 0.61, about the same degree of clinical similarity exists within siblings as it does between siblings, in terms of hemoglobin, total bilirubin, splenectomy status, and cholecystectomy status. Pregnancy outcomes were similar across genotypes in PK deficient women. This report confirms the wide genetic heterogeneity of PK deficiency. 相似文献
103.
104.
Ebru Akgul M.D. Utku Kutuk M.D. Sibel Ertek M.D. Mustafa Cesur M.D. Sengul Cehreli M.D. Hasan Fehmi Tore M.D. Gurbuz Erdogan M.D. 《Echocardiography (Mount Kisco, N.Y.)》2011,28(1):15-21
Objective: Autoimmune chronic thyroiditis (ACT) is characterized by lymphocyte infiltration in the thyroid gland and the presence of antithyroid antibodies in serum. Medical treatment does not affect antibody levels and treatment decision is not definite yet for the euthyroid patients. We aimed to evaluate cardiac autonomic function and global left ventricular performance in autoimmune euthyroid chronic thyroiditis and determine the need for medical treatment. Method: We studied 30 ACT patients and 25 healthy control subjects. Cardiac autonomic function is evaluated by heart rate recovery (HRR). Global left ventricular performance is evaluated by two‐dimensional echocardiography and pulsed‐wave tissue Doppler echocardiography. Results: There was no difference between patients and controls with respect to clinical and biochemical parameters except hemoglobin (13.67 ± 1.25 g/dL, 14.51 ± 1.35 g/dL, p:0.047) and low density lipoprotein (120.71 ± 24.91 mg/dL, 100.55 ± 14.73 mg/dL, p: 0.003). Tei index was significantly higher in ACT group (0.521 ± 0.074, 0.434 ± 0.034, P < 0.0001). E′/A′ was found to be significantly lower (1.234 ± 0.42, 1.750 ± 0.291, P < 0.0001) and E/E′ was found to be higher than the controls (8.482 ± 0.449, 6.039 ± 0.209, P < 0.0001). HRR was significantly lower than the controls (20 ± 4 BPM, 30 ± 8 BPM, P < 0.0001). Conclusion: Although left ventricular performance is found to be normal by conventional echocardiographic methods, it is found to be impaired when Tei index and tissue Doppler parameters are used. Cardiac autonomic function is also impaired in ACT patients. As a result of these cardiac changes, medical treatment may be considered earlier, even at the euthyroid stage. (Echocardiography 2011;28:15‐21) 相似文献
105.
Turan Şenol Boysan Murat Tarakçıoğlu Mahmut Cem Sağlam Tarık Yassa Ahmet Bakay Hasan Demirel Ömer Faruk Tosun Musa 《Archives of sexual behavior》2021,50(3):885-895
Archives of Sexual Behavior - We compared gender dysphoria (GD) patients and their same-sex siblings in terms of their 2D:4D ratios, which may reflect prenatal exposure to androgen, one of the... 相似文献
106.
Hasan Fatih ?ay Ilhan Sezer Mehmet Z. Firat Cahit Ka?ar 《Rheumatology international》2011,31(3):377-385
It is believed that there is an association between the weather and rheumatic symptoms. We aimed to investigate what kind
of association is present and what are the factors which determine the nature of this association. Fifty-six subjects with
rheumatic disease (31 RA, 15 SpA, 10 OA) who live in Antalya were followed between December 2005 and July 2006. Patients were
asked to fill diaries which contain questions regarding the symptoms of their rheumatic diseases everyday. In every monthly
visit, disease activity measurement, laboratory assessment and Beck depression inventory assessment were recorded. The symptomatic
and psychological measurements were matched with the meteorological data of Antalya Regional Directorate of Meteorological
Service of Turkish State. Correlation of symptoms with weather variables was investigated. Contributory effect of weather
and of psychologic factors on symptom scores were evaluated by stepwise multiple regression analysis. Eighty-four percent
of subjects belive in an association between weather and rheumatism, while 57% claimed to have ability to forecast weather.
The maximum correlation coefficient between weather and arthritis symptoms was −0.451 and the maximum contribution of weather
on symptoms was 17.1%. Arthritis symptoms were significantly contributed by Beck depression score. The belief about presence
of weather–arthritis association was found to be stronger than its statistical power. Our results did not prove or rule out
the presence of weather–rheumatism association. As long as the scientific attempts result in failure, the intuitive support
in favour of the presence of weather–arthritis association will go on forever. 相似文献
107.
Berkdemir Siverekli N Sahin O Senel S Hayta E Kaptanoglu E Elden H 《Rheumatology international》2012,32(8):2453-2457
The aim of this study was to evaluate the bone mineral density (BMD) in familial Mediterranean fever (FMF) and to search the effects of genetic factors, family history of FMF and types of clinical attacks on BMD. Forty-four attack-free patients with FMF and 36 healthy voluntary subjects were included in the study. BMD measurements of lumbar spine and left proximal femur were performed by dual energy X-ray absorptiometry (DEXA). There was no statistically significant difference between patient and control groups regarding median values of lumbar BMD (P?=?0.06), lumbar T (P?=?0.08) and Z (P?=?0.12) scores, femoral neck BMD (P?=?0.13), femoral T (P?=?0.22) and Z (P?=?0.16) scores and total femur BMD (P?=?0.14), T (P?=?0.19) and Z (P?=?0.27) scores. Patients with negative FMF family history had significantly lower femoral neck BMD (P?=?0.018), femoral neck T (P?=?0.009) and Z (P?=?0.01) scores and total femur BMD (P?=?0.033) than patients with positive FMF family history. There was no significant difference among the groups regarding mutation characteristic and types of attacks in lumbar BMD, T and Z scores, femoral neck BMD, T and Z scores and total femur BMD, T and Z scores (P?>?0.05). We found that the bone loss of patients with FMF is not different from that of the controls. The increased bone loss in the patients with negative family history for FMF should be further investigated with larger patient groups taking into consideration of the risk factors related to family history for osteoporosis. 相似文献
108.
109.
110.
Bindey Kumar Prem Kumar Sanjay Kumar Sinha Neelam Sinha Zaheer Hasan Vinit Kumar Thakur Utpal Anand Rajiv Nayan Priyadarshi Manish Mandal 《International journal of surgery case reports》2013,4(4):425-428
INTRODUCTIONForeign bodies in the urogenital tract are not uncommon. Hairpins, glass rods, umbilical tapes, ball point pen are described in lower urogenital tract. Retained gauze piece (gossypiboma) in posterior urethra may cause diagnostic dilemma. Symptoms and investigations may mimic stricture of posterior urethra.PRESENTATION OF CASETwo cases of retained gauze pieces in the urethra are described here. The micturating cystourethrogram was suggestive of posterior urethral stricture.DISCUSSIONTwo cases described here had retained gauze piece as a cause of filling defect and abnormal appearance in the micturating cystourethrogram. Gossypiboma may be a possibility where posterior urethral stricture are seen after previous surgery in paediatric age group.CONCLUSIONIn the setting of previous urogenital surgery gossypiboma should be kept in the differential diagnosis where posterior urethral stricture are seen in the paediatric age group. 相似文献