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931.
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Hirabidian Mickaël Thierry Saelens Deleplancque Anne-Sophie Bergues Benoît Loridant Séverine Cornu Marjorie Sendid Boualem Leroy Jordan 《European journal of clinical microbiology & infectious diseases》2023,42(6):781-786
European Journal of Clinical Microbiology & Infectious Diseases - Toxocariasis is a cosmopolitan helminthiasis linked to contamination with Toxocara cati or Toxocara canis. Only six isolated... 相似文献
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Aurélie Bocquier PhD Sébastien Bruel MD MSc Morgane Michel MD PhD Anne-Sophie Le Duc-Banaszuk MD Stéphanie Bonnay MScA Marion Branchereau MSocS Karine Chevreul MD PhD Sandra Chyderiotis PharmD PhD Aurélie Gauchet PhD Bruno Giraudeau PhD Dragos-Paul Hagiu MD MSc Judith E. Mueller MD MPH PhD Amandine Gagneux-Brunon MD PhD Nathalie Thilly PharmD PhD PrevHPV Study Group 《Health expectations》2023,26(5):1843-1853
935.
Anne-Sophie Boureau MD PhD Béatrice Guyomarch MSc Pierre Gourdy MD PhD Ingrid Allix MD Cédric Annweiler MD PhD Nathalie Cervantes MD Guillaume Chapelet MD Isabelle Delabrière MD Sophie Guyonnet PhD Rachel Litke MD PhD Marc Paccalin MD PhD Alfred Penfornis MD PhD Pierre-Jean Saulnier MD PhD Matthieu Wargny MD PhD Samy Hadjadj MD PhD Laure de Decker MD PhD Bertrand Cariou MD PhD 《Journal of the American Geriatrics Society》2023,71(7):2107-2119
Background
There is a lack of real-life data regarding the frequency and predictive factors of hypoglycemia in older patients with type 2 diabetes (T2D). This study aimed to determine the frequency and predictors of hypoglycemia in older patients with insulin-treated T2D.Methods
This prospective multicenter study included 155 insulin-treated T2D patients aged 75 years and older with ≥2 self-monitoring of blood glucose (SMBG) daily controls. Participants underwent a geriatric and diabetic assessment and received ambulatory blinded continuous glucose monitoring (CGM) for 28 consecutive days with FreeStyle Libre Pro® sensor. Study population (n = 141) has >70% CGM active time. Multivariable logistic regressions were used to identify factors associated with SMBG confirmed hypoglycemia (≥70 mg/dL) and with nocturnal level 2 time below range (glucose concentration <54 mg/dL during ≥15 consecutive min between 0.00 and 6.00 am).Results
The mean age of the 141 analyzed patients was 81.5 ± 5.3 years and 56.7% were male. The mean baseline HbA1c was 7.9% ± 1.0%. After geriatric assessment, 102 participants (72.3%) were considered as complex and 39 (27.7%) as healthy. The primary endpoint (confirmed SMBG <70 mg/dL) occurred in 37.6% patients. In multivariable analysis, the risk of SMBG-confirmed hypoglycemia was positively associated with a longer duration of diabetes (OR (+1 year) =1.04, (1.00–1.08), p = 0.04) and glycemic variability assessed by CGM (CV %) (OR (+1%) = 1.12, [1.05–1.19], p = <0.001). Nighty-two patients (65.2%) experienced nocturnal time in hypoglycemia (i.e., <54 mg/dL during ≥15 consecutive min between midnight and 6 a.m.). In multivariable analyses, cognitive impairment (OR: 9.31 [2.59–33.4]), heart failure (OR: 4.81 [1;48–15.6]), and depressive disorder (OR: 0.19 [0.06–0.53]) were associated with nocturnal time in hypoglycemia.Conclusion
Nocturnal hypoglycemia is very common and largely underdiagnosed in older patients with insulin-treated T2D. CGM is a promising tool to better identify hypoglycemia and adapt diabetes management in this population. 相似文献936.
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939.
Anne-Sophie M. W. Bekhof Florence P. A. M. van Hunsel Sonja van de Koppel Herman J. Woerdenbag 《Phytotherapy research : PTR》2023,37(4):1309-1318
Tea tree (Melaleuca alternifolia) essential oil is widely used as an antiseptic. It mainly consists of monoterpenes with terpinen-4-ol as the major constituent. The aim of this study was to review literature on safety data about tea tree oil and to assess its safety by investigating 159 cases of adverse reactions possibly caused by the oil, reported to the World Health Organization (WHO) from December 1987 until September 2021. To extract these data, VigiBase, the WHO global database of individual case safety reports maintained by the Uppsala Monitoring Centre (UMC), was used. All cases were categorized and analysed and 16 serious cases further assessed. It was concluded that tea tree oil should never be administered orally, as it can lead to central nervous system depression and pneumonitis. Applied topically, skin disorders may occur, especially when the oil had been exposed to light or air. This yields monoterpene oxidation products, being potent skin irritants. Tea tree oil stored under appropriate conditions and not exceeding the expiration date should be considered safe to use by non-vulnerable people for non-serious inflammatory skin conditions, although the occurrence of adverse reactions such as contact allergies is difficult to predict. 相似文献