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Graillon Thomas Passeri Thibault Boucekine Mohamed Meyer Mikael Abritti Rosaria Bernat Anne-Laure Labidi Moujahed Dufour Henry Froelich Sébastien 《Pituitary》2021,24(2):292-301
Pituitary - Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical... 相似文献
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Anne-Laure Lapeyraque Nastya Kassir Yves Théorêt Maja Krajinovic Marie-José Clermont Catherine Litalien Véronique Phan 《Pediatric nephrology (Berlin, Germany)》2014,29(6):1081-1088
Background
The objectives of this study were to investigate pharmacokinetic and pharmacogenetic parameters during the conversion on a 1:1 (mg:mg) basis from a twice-daily (Prograf) to once-daily (Advagraf) tacrolimus formulation in pediatric kidney transplant recipients.Methods
Twenty-four-hour pharmacokinetic profiles were analyzed before and after conversion in 19 stable renal transplant recipients (age 7–19 years). Tacrolimus pharmacokinetic parameters [area under the concentration-time curve (AUC0–24), minimum whole-blood concentration (Cmin), maximum whole-blood concentration (Cmax), and time to achieve maximum whole-blood concentration (tmax)] were compared between Tac formulations and between CYP3A5 and MDR1 genotypes after dose normalization.Results
Both AUC0–24 and Cmin decreased after conversion (223.3 to 197.5 ng.h/ml and 6.5 to 5.6 ng/ml; p?=?0.03 and 0.01, respectively). However, the ratio of the least square means (LSM) for AUC0–24 was 90.8 %, with 90 % CI limits of 85.3 to 96.7 %, falling within bioequivalence limits. The CYP3A5 genotype influences the dose-normalized Cmin with the twice-daily formulation only.Conclusions
Both tacrolimus formulations are bioequivalent in pediatric renal recipients. However, we observed a decrease in AUC0–24 and Cmin after the conversion, requiring close pharmacokinetic monitoring during the conversion period. 相似文献24.
Simon Giroux Jinwang Xu T. Jagadeeswar Reddy Mark Morris KevinM. Cottrell Caroline Cadilhac James A. Henderson Oliver Nicolas Darius Bilimoria Francois Denis Nagraj Mani Nigel Ewing Rebecca Shawgo Lucille L’Heureux Subajini Selliah Laval Chan Nathalie Chauret Francoise Berlioz-Seux Mark N. Namchuk Anne-Laure Grillot Youssef L. Bennani Sanjoy K. Das John P. Maxwell 《ACS medicinal chemistry letters》2014,5(3):240-243
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Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity. 总被引:1,自引:0,他引:1
Lionel Ho Anne-Laure Gaudieux Stella Fanok Gayle Newcombe Andrew R Humpage 《Toxicon》2007,50(3):438-441
Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal. 相似文献
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Methadone maintenance treatment,criminality and overdose-related deaths. An ecological study, 1983-1999 总被引:1,自引:0,他引:1
BACKGROUND: Methadone maintenance treatments (MMTs) are the commonest substitution treatments offered to opiate addiction in Switzerland, in order to reduce criminal behaviour, infectious disease transmission and overdose death. METHOD: To investigate the relationship between the increase in the number of methadone maintenance treatments, criminal activity of addicts and overdose-related deaths, an ecological study was undertaken in the Canton of Geneva, from 1983 to 1999. RESULTS: The regular and extensive increase in the number of MMTs is not significantly associated, during the 1983-1999 period, with a fall either in drug addict incarcerations or in overdose-related deaths. However, a slight decrease is observed in the number of imprisoned opiate addicts since 1994, and a marked decrease is seen in overdose deaths from 1997 on. An important and stable number of these deaths is due to methadone itself. CONCLUSION: Public health objectives to diminish delinquency and overdose deaths cannot solely be fulfilled by extensive use of MMTs. A positive result could appear when access to MMT is highly favoured. This hypothesis must be proved correct by observational studies conducted on a general population. 相似文献
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Puaux AL Marsac D Prost S Singh MK Earl P Moss B Le Grand R Riviere Y Michel ML 《Vaccine》2004,22(27-28):3535-3545
Recent efforts to design an human immunodeficiency virus type 1 (HIV-1) vaccine candidate have focused on means of eliciting anti-viral T-cell responses. We tried to improve the immunogenicity of DNA vaccines by designing hybrid DNA constructs encoding hepatitis B surface antigen (HBsAg) fused to antigenic domains of simian/human immunodeficiency virus (SHIV 89.6P). Immunisation with hybrid DNA induced both effector and long-lasting precursor T-cells. Following boosting with a recombinant modified vaccinia Ankara (rMVA) producing full-length SIV and HIV antigens, it appeared that priming with hybrid DNA had increased virus-specific T-cell responses in terms of both the number of virus-specific IFN-gamma-secreting T-cells and virus-specific lymphoproliferation. After intrarectal challenge with SHIV 89.6P, immunised animals demonstrated early control of SHIV 89.6P replication and stable CD4+ T-cell counts. 相似文献