全文获取类型
收费全文 | 3098篇 |
免费 | 192篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 71篇 |
妇产科学 | 57篇 |
基础医学 | 557篇 |
口腔科学 | 47篇 |
临床医学 | 282篇 |
内科学 | 507篇 |
皮肤病学 | 70篇 |
神经病学 | 412篇 |
特种医学 | 104篇 |
外国民族医学 | 4篇 |
外科学 | 286篇 |
综合类 | 8篇 |
一般理论 | 3篇 |
预防医学 | 308篇 |
眼科学 | 51篇 |
药学 | 247篇 |
中国医学 | 13篇 |
肿瘤学 | 229篇 |
出版年
2023年 | 37篇 |
2022年 | 59篇 |
2021年 | 95篇 |
2020年 | 53篇 |
2019年 | 82篇 |
2018年 | 100篇 |
2017年 | 74篇 |
2016年 | 98篇 |
2015年 | 89篇 |
2014年 | 120篇 |
2013年 | 135篇 |
2012年 | 247篇 |
2011年 | 244篇 |
2010年 | 157篇 |
2009年 | 119篇 |
2008年 | 236篇 |
2007年 | 199篇 |
2006年 | 165篇 |
2005年 | 153篇 |
2004年 | 163篇 |
2003年 | 172篇 |
2002年 | 104篇 |
2001年 | 21篇 |
2000年 | 27篇 |
1999年 | 30篇 |
1998年 | 34篇 |
1997年 | 34篇 |
1996年 | 15篇 |
1995年 | 11篇 |
1994年 | 16篇 |
1993年 | 6篇 |
1992年 | 19篇 |
1991年 | 22篇 |
1990年 | 19篇 |
1989年 | 9篇 |
1988年 | 15篇 |
1987年 | 19篇 |
1986年 | 19篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1979年 | 10篇 |
1977年 | 4篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1972年 | 8篇 |
1971年 | 10篇 |
1970年 | 4篇 |
1969年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有3296条查询结果,搜索用时 10 毫秒
41.
42.
Anke Augspach Joachim H. List Philipp Wolf Heike Bielek Carsten Schwan Ursula Els?sser-Beile Klaus Aktories Gudula Schmidt 《Toxins》2013,5(11):2241-2257
Prostate cancer is the most common malignancy, accounting for about 25% of all incident cases among men in industrialized countries. The human androgen-dependent prostate cancer cell line LNCaP, which is derived from a metastatic lesion of human prostatic adenocarcinoma, is frequently used to study prostate cancer associated signaling pathways in vitro. Recently it was described that Rho GTPase activation in these cells leads to apoptotic responses. We used the bacterial toxins CNFy and CNF1, which specifically and directly activate Rho GTPases by deamidation of a single glutamine. We asked whether these Rho activators could induce apoptosis in LNCaP cells. Our results indicate that RhoA activation, induced by CNFy, does lead to intrinsic apoptosis of the cells. Analysis of the underlying signaling pathway reveals that apoptosis induction requires the activity of Rho kinase (ROCK) and myosin activation, an apoptotic pathway previously identified in cancer stem cells. 相似文献
43.
44.
Pantelis D Beissel A Kahl P Vilz TO Stoffels B Wehner S Kalff JC 《International journal of colorectal disease》2011,26(6):737-746
Purpose
Prevention of perioperative activation of intestinal muscularis macrophages is a promising intervention to avoid post-traumatic gastrointestinal tract dysfunction. However, impaired macrophage function could have deleterious consequences on anastomotic healing, especially in complications aggravating the healing process itself, such as infectious problems either as preexisting local inflammation or infection (e.g., complicated diverticulitis) or endotoxemia due to early postoperative infections (e.g., pneumonia). Aim of this study was to investigate colonic anastomotic healing in macrophage-depleted mice in the presence of endotoxemia. 相似文献45.
46.
47.
Anke M. Scheeren Hans M. Koot Sander Begeer 《Journal of autism and developmental disorders》2012,42(10):2046-2055
Qualitative differences in social interaction style exist within the autism spectrum. In this study we examined whether these differences are associated with (1) the severity of autistic symptoms and comorbid disruptive behavior problems, (2) the child’s psycho-social health, and (3) executive functioning and perspective taking skills. The social interaction style of 156 children and adolescents (6–19?years) with high-functioning autism spectrum disorder (HFASD) was determined with the Wing Subgroups Questionnaire. An active-but-odd social interaction style was positively associated with symptoms of autism, attention deficit and hyperactivity. Furthermore, an active-but-odd social interaction style was negatively associated with children’s psycho-social health and positively with executive functioning problems. Social interaction style explains part of the heterogeneity among children with HFASD. 相似文献
48.
Martin L. Pittorf Wolfgang Lehmann Anke Huckauf 《Early child development and care》2014,184(6):843-854
In this study the visual working memory (VWM) and perception speed of 60 children between the ages of three and six years were tested with an age-based, easy-to-handle Matrix Film Battery Test (reliability R?=?.71). It was thereby affirmed that the VWM is age dependent (correlation coefficient r?=?.66***) as expected. Furthermore, a significant gender effect was found (partial correlation coefficient rp?=?.42***) indicating that boys generally have a better VWM: they are able to memorise more items and they can process visual information faster. Given that the test was repeated during a period of eight months, strong learning effects could be detected which show that the VWM can be trained and that the test itself is also a good training tool. 相似文献
49.
50.
Coronary flow regulation in mouse heart during hypercapnic acidosis: role of NO and its compensation during eNOS impairment 总被引:2,自引:0,他引:2
AIMS: This study addressed the hypotheses that the hypercapnic flow response in wild-type (WT) mouse heart is mainly mediated by nitric oxide (NO) and, thus, severely blunted in endothelial nitric oxide synthase knockout (eNOS-KO) mice and in WT mice after continuous pharmacological block (2 weeks) of NOS enzymes (WT-LN). METHODS AND RESULTS: Step changes of arterial pCO(2) were performed in isolated perfused hearts (n = 105). Contributions of NOS (L-NAME, TRIM), cyclooxygenase (indomethacin), epoxyeicosanotrienes (miconazole), adenosine A2A-receptors (SCH 58261), KV-channels (4-AP), KCa-channels (TEA), and K ATP-channels (glibenclamide) were studied in WT and eNOS-KO mouse hearts. Change of arterial pCO(2) increased coronary flow by 31.3 +/- 4% in WT, a response that was significantly decreased to 9.2 +/- 6% after L-NAME. Additional glibenclamide infusion (n = 5) completely abolished the steady-state flow increase during hypercapnic acidosis (-4.2 +/- 2.3%, P = 0.004 vs. control). Hearts from eNOS-KO mice as well as WT-LN showed a fully preserved flow response insensitive towards NOS-blockade. Whereas indomethacin, miconazole, TEA, and SCH 58261 were ineffective to reduce the flow response, glibenclamide blunted it in eNOS-KO hearts. CONCLUSION: NO-production and K ATP-channel activation together may fully account for the steady-state hypercapnic flow response in mouse heart. However, chronic deletion of eNOS does not result in a reduced hypercapnic flow response. Enhanced activation of K ATP-channels and potentially Kv-channels contributes to the compensatory mechanisms involved in the hypercapnic flow response when eNOS activity is absent. 相似文献