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排序方式: 共有6876条查询结果,搜索用时 15 毫秒
81.
Cristina Maria de Souza Conrado de Oliveira Gamba Cecília Bonolo de Campos Miriam Teresa Paz Lopes Mônica Alves Neves Diniz Ferreira Silvia Passos Andrade Geovanni Dantas Cassali 《Pathology, research and practice》2013
Carboplatin is commonly used to treat a variety of tumors. We investigated the effects of carboplatin (100 mg/kg) in the development and metastatic dissemination of the 4T1 mice mammary carcinoma. Carboplatin was able to reduce tumor volume and the number of lung metastases in 50% compared to the control animals. Mitotic and apoptotic indices were also decreased by the treatment. Assessment of the vascularization of the tumors revealed a significant decrease in blood vessel formation by carboplatin. A decrease in nuclear positivity of CDC47 and cyclin D1 was observed in the group treated with carboplatin when compared to the control group. Positivity for p53 was observed in the control group (2/28; 5%) and the treated group (5/71; 4%). Carboplatin has been demonstrated to be an efficient regulator of 4T1MMT growth and dissemination. The action of this chemotherapeutic agent seems to be related to the induction of apoptosis and inhibition of angiogenesis and cell proliferation. 相似文献
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Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study
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![点击此处可从《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Rafael José Pio Barbosa Teixeira Natália Silva Andrade Lisanca Carvalho Cavalcante Queiroz Fausto Medeiros Mendes Marcoeli Silva Moura Lúcia de Fátima Almeida de Deus Moura Marina Deus Moura Lima 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2018,28(2):198-206
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Ana Rachel Oliveira de Andrade Maria Elizabeth Moraes Cavalheiros Dorva Sonia Maria Oliveira de Andrade Alisson Marques Baldomero Antonio Kato da Silva Renato Andreotti 《亚太热带病杂志(英文版)》2012,2(5):362-366
ObjectiveTo identify the urban phlebotomine sandfly fauna in Ponta Porã, Mato Grosso do Sul State, Brazil.MethodsThe captures were undertaken from April 2009 to March 2010 with CDC light traps in 14 ecotopes (intra and peridomicile) in different areas of the city, Shannon traps being used in areas with abundant vegetation.ResultsA total of 707 specimens were captured with CDC light traps (565 males and 142 females) and 155 specimens (112 males and 43 females) with Shannon traps, a total of 862 phlebotomines. The specimens captured belonged to eight species: Lutzomyia longipalpis (Lutz & Neiva, 1912), Evandromyia cortelezzii (Brethes, 1923), Sciopemyia sordelli (Shannon & Del Ponte, 1927), Pintomyia pessoai (Coutinho & Barretto, 1940); Pintomyia monticola (Costa Lima, 1932); Brumptomyia brumpti (Larousse, 1920); Nyssomyia whitmani (Antunes & Coutinho, 1939) and Psathyromyia shannoni (Dyar, 1929). Lutzomyia longipalpis, the main vector of Leishmania (Leishmania) chagasi, was the species most frequently captured (97.03%) and also the most abundant according to the standardized abundance index (SAI)=0.86.ConclusionsThe highest species richness was captured, with CDC light traps, inside the domiciles and the species diversity and evenness in the peridomicile, clearly indicating a preference for anthropic environments. 相似文献
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The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys
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![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Louisa Degenhardt Sukanta Saha Carmen C. W. Lim Sergio Aguilar‐Gaxiola Ali Al‐Hamzawi Jordi Alonso Laura H. Andrade Evelyn J. Bromet Ronny Bruffaerts José Miguel Caldas‐de‐Almeida Giovanni de Girolamo Silvia Florescu Oye Gureje Josep M. Haro Elie G. Karam Georges Karam Viviane Kovess‐Masfety Sing Lee Jean‐Pierre Lepine Victor Makanjuola Maria E. Medina‐Mora Zeina Mneimneh Fernando Navarro‐Mateu Marina Piazza José Posada‐Villa Nancy A. Sampson Kate M. Scott Juan Carlos Stagnaro Margreet Ten Have Kenneth S. Kendler Ronald C. Kessler John J. McGrath 《Addiction (Abingdon, England)》2018,113(5):924-934
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Ewelyne M. de Lima Andrews M. do Nascimento Girlandia A. Brasil Placielle F. Filete Ieda C. Kalil Dominik Lenz Denise C. Endringer Nazaré S. Bissoli Tadeu U. de Andrade 《Fundamental & clinical pharmacology》2016,30(4):316-326
This study evaluated the effects of the isolated use of a low dose of methyltestosterone (MT) on cardiovascular reflexes and hormonal levels and its geno‐ and cytotoxic safety in ovariectomized rats. Female Wistar rats were divided into four groups (n = 6), respectively: SHAM (received vehicle methylcellulose 0.5%), SHAM + MT (received MT 0.05 mg/kg), OVX (received vehicle), and OVX + MT (received MT). Twenty‐one days after ovariectomy, treatment was given orally daily for 28 days. The Bezold–Jarisch reflex (BJR) was analyzed by measuring the bradycardic and hypotensive responses elicited by phenylbiguanide (PBG) administration. The baroreflex sensitivity (BRS) was evaluated by phenylephrine and sodium nitroprussite. Myocyte hypertrophy was determined by morphometric analysis of H&E stained slides. Biochemical data were analyzed, as well as micronucleus assay. MT improved BRS and increased testosterone values, but did not change estradiol in the OVX group. MT did not promote changes in mean arterial pressure, heart rate, BJR, serum concentrations of troponin I, weight and histopathology of the heart. MT was able to restore the BRS in OVX rats. The geno‐ and cytotoxic safety of the MT was demonstrated by the absence of an increase in the micronucleus (PCEMN) or change in the ratio between normochromatic erythrocytes and polychromatic erythrocytes (NCE/PCE). 相似文献