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91.
S-15176 reduces the hepatic injury in rats subjected to experimental ischemia and reperfusion 总被引:1,自引:0,他引:1
Settaf A Zahidy M Elimadi A Sapena R Alsamad IA Tillement J Morin D 《European journal of pharmacology》2000,406(2):281-292
The protective effect of N-[(3, 5-di-tertiobutyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3, 4-trimethoxybenzyl)piperazine (S-15176) on liver injury induced by warm ischemia-reperfusion was investigated using a rat model. Animals were subjected to 2 h of ischemia followed by different reperfusion times. Hepatocyte integrity was assessed by measuring plasma alanine and aspartate aminotransferase activities, and by determining reduced and oxidized glutathione in plasma and bile. Hepatocyte function was quantitated by determining bile flow and liver ATP content. Ischemia-reperfusion resulted in severe hepatic injury involving a huge increase in alanine and aspartate aminotransferase activities, a drop in ATP content, and a decrease in bile flow. Plasma and bile reduced (GSH) and oxidized (GSSG) glutathione concentrations were inversely related: plasma levels increased when biliary levels decreased. This was associated with a decrease in animal survival (-34%). S-15176 pretreatment (1.25, 2.5, 5 or 10 mg kg(-1) day(-1)) improved the survival rate and limited tissue damages in a dose-dependent manner. The pretreatment also reduced the aminotransferase leakage from hepatocytes and the increase in plasma glutathione levels. In addition, normalization of the plasma GSSG/GSH ratio, a good index of an oxidative stress, was observed in groups treated with the higher dosage, suggesting that the antioxidant properties demonstrated for the compound in vitro (IC(50)=0.3 microM towards lipid peroxidation) could play a role in its protective effect. S-15176 pretreatment also protected the organ from the drop in ATP levels. At the higher dose, ATP content was maintained at a level almost 86% of the sham-operated group after 60 min of reperfusion. This was associated with a restoration of the biliary flow. These data suggest that S-15176 may be a useful drug in liver surgery to prevent ischemia-reperfusion injury. 相似文献
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ML Harries JM Walker DM Williams S Hawkins IA Hughes 《Archives of disease in childhood》1997,77(5):445-447
The changes in the male voice in relation to the biological characteristics of puberty were assessed longitudinally in 26 boys. Speaking and singing fundamental frequencies were analysed in relation to the Tanner staging of puberty, saliva testosterone levels, and the Cooksey classification of voice analysis. There were abrupt changes in voice characteristics between Tanner stages G3 and G4 and more gradually from stages C3 to C5 of Cooksey. Although testosterone concentrations were not predictive of the changes, there was a correlation with testis volume. Voice fundamental frequencies were seen to change abruptly in late puberty, in contrast with previous studies. There is a good correlation between the Tanner and Cooksey methods of classification during male puberty. 相似文献
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Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies 总被引:8,自引:1,他引:8
Myatt L; Eis AL; Brockman DE; Greer IA; Lyall F 《Human reproduction (Oxford, England)》1997,12(1):167-172
Nitric oxide (NO) regulates blood flow in the human placenta. As increased
resistance to blood flow is seen in the fetal-placental vasculature in
pregnancies complicated by pre-eclampsia and/or intrauterine growth
restriction (IUGR), we examined expression of endothelial nitric oxide
synthase (eNOS) in these placentas. Placental villous tissue sections were
obtained from normotensive control (n = 5), IUGR alone (n = 5) or
pre-eclamptic (with or without IUGR (n = 9) patients, immunostained for
eNOS and scored for localization, type (punctate or diffuse) and intensity
of eNOS staining in syncytiotrophoblast and placental vessels. The
significance of differences was calculated using the Mann-Whitney U-test.
No differences in intensity or type of immunostaining in
syncytiotrophoblast were seen. Placentas from patients with pre- eclampsia
with or without IUGR had a significantly more basal distribution of eNOS in
syncytiotrophoblast. eNOS immunostaining was absent in terminal villous
capillary and faint in stem villous vessel endothelium of normal placentas,
but was intense in the endothelium of both of these types of vessels in the
IUGR and pre-eclampsia groups, with significantly greater staining seen in
stem vessels of patients with IUGR alone. This increased eNOS expression
and hence increased NO production in the fetal-placental vasculature may be
an adaptive response to the increased resistance and poor perfusion in
these pathological pregnancies.
相似文献
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P16和视网膜母细胞瘤蛋白在高砷煤引起的砷中毒患者皮损中的表达 总被引:8,自引:3,他引:5
目的 研究P16和视网膜母细胞瘤蛋白(Rb)在高砷煤引起的砷中毒患者皮损中的表达.方法 采用免疫组化SP法检测46例高砷煤引起的砷中毒患者皮损中P16和Rb蛋白的表达.结果 高砷煤引起的砷中毒患者皮损中P16蛋白的表达缺损率为59.7%,其表达随病损的加剧而减低,并与临床分级和病理分型明显相关(P<0.01).Rb蛋白的阳性表达率为60.9%,与临床分级相关(P<0.05).P16蛋白的阳性表达与Rb蛋白呈负相关(P<0.01).结论 P16蛋白表达降低和P16-Rb通路的失活可能与高砷煤引起的砷中毒患者皮损的发生密切相关. 相似文献