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81.
Kemal Agbaht Funda Pepedil Alper Kirkpantur Rahmi Yilmaz Cetin Turgan 《Renal failure》2013,35(1):107-110
Kaposi's sarcoma (KS) is an unusual tumor principally affecting the skin of the lower extremities. Although the association between KS and renal transplant has been well documented, there are a few KS cases in the literature associated with membranoproliferative glomerulonephritis or other glomerular diseases. This report presents a patient with membranoproliferative glomerulonephritis (MPGN) who developed KS following treatment with long-term medium dose glucocorticoid and short-term additional immunosuppressives. The KS cases associated with glomerulonephritis are also reviewed. KS is a rare complication in glomerular diseases that may (or may not) be related to immunosuppression. Hence, immunosuppression treatment should be carefully planned in glomerulonephritis treatment and avoided if they are not essentially necessary. 相似文献
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Sezgin Gunes Gulgez Neslihan Taskurt Hekim Mehmet Alper Arslan Ramazan Asci 《Journal of assisted reproduction and genetics》2016,33(4):441-454
The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitary-gonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men. 相似文献
87.
Derya Algul Alper Gokce Ayberk Onal Erkan Servet Asiye Isın Dogan Ekici Fatma Gulgun Yener 《Journal of biomaterials science. Polymer edition》2016,27(5):431-440
Biomimetic three-layered monolithic scaffold (TLS) intended for the treatment of osteocondral defects was prepared by using alginate, chitosan and β-tricalcium phosphate (β-TCP) to study drug release behavior of the alternative drug delivery system and to investigate the therapeutic efficacy of the scaffold. Dexamethasone sodium phosphate (Dex) as a model drug was incorporated into the scaffold by solvent sorption method and in vitro release studies were conducted. In addition, the scaffold was implanted into the defects formed in the trochlea of Sprague–Dawley rats to assess the healing potential of the TLS on the osteochondral defect against reference Maioregen® comparatively. The release studies showed that after an initial burst at 3rd h, dexamethasone is released slowly during a 72-h period. In vivo studies indicated that the TLS has good tissue biocompatibility and biodegradation rate and showed better results during osteochondral healing process compared to the reference. All results demonstrated that the alginate-chitosan/β-TCP scaffold could be evaluated as a good candidate for osteochondral tissue applications. 相似文献
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Stewart AK Kurschat CE Alper SL 《Pflügers Archiv : European journal of physiology》2007,454(3):373-384
The ubiquitous AE2/SLC4A2 anion exchanger is acutely and independently regulated by intracellular (pHi) and extracellular pH (pHo), whereas the closely related AE1/SLC4A1 of the red cell and renal intercalated cell is relatively pH-insensitive. We have
investigated the contribution of nonconserved charged residues within the C-terminal transmembrane domain (TMD) of AE2 to
regulation by pH through mutation to the corresponding AE1 residues. AE2-mediated Cl−/Cl− exchange was measured as 4,4′-di-isothiocyanatostilbene-2,2′-disulfonic acid-sensitive 36Cl− efflux from Xenopus oocytes by varying pHi at constant pHo, and by varying pHo at near-constant pHi. All mutations of nonconserved charged residues of the AE2 TMD yielded functional protein, but mutations of some conserved
charged residues (R789E, R1056A, R1134C) reduced or abolished function. Individual mutation of AE2 TMD residues R921, F922,
P1077, and R1107 exhibited reduced pHi sensitivity compared to wt AE2, whereas TMD mutants K1153R, R1155K, R1202L displayed enhanced sensitivity to acidic pHi. In addition, pHo sensitivity was significantly acid- shifted when nonconserved AE2 TMD residues E981, K982, and D1075 were individually converted
to the corresponding AE1 residues. These results demonstrate that multiple conserved charged residues are important for basal
transport function of AE2 and that certain nonconserved charged residues of the AE2 TMD are essential for wild-type regulation
of anion exchange by pHi and pHo.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
A. K. Stewart and C. E. Kurschat have contributed equally to this work. 相似文献