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991.
992.
Sahu B Ozturk O Deo N Fordham K Ranierri M Serhal P 《Journal of assisted reproduction and genetics》2008,25(1):1-5
Purpose In women the relationship between myotonic dystrophy type I and fertility remains controversial. The objective of this study
was to evaluate the ovarian reserve, ovarian response to stimulation and oocyte quality in these patients.
Materials and methods We compared 15 myotonic dystrophy type I patients with 39 age matched controls with isolated male factor infertility necessitating
ICSI.
Results All parameters of ovarian reserve (day 3 FSH and E2, antral follicle count and delta E2) were significantly better in the
controls. Despite having significantly lower doses of gonadotrophin, the control group attained a higher number of retrieved
oocyte–cumulus complexes (p < 0.04). Analysis of cytoplasmic and extracytoplasmic dysmorphism did not reveal any difference between the two groups. Fertilisation
rate and top grade embryos on day 3 were similar in both groups.
Conclusion The present study suggests that though women with myotonic dystrophy type I have a reduced ovarian reserve and respond poorly
to controlled ovarian stimulation, there is no impact on oocyte and embryo quality. Hence suggesting that successful ART is
feasible with appropriate selection in women with mild myotonic dystrophy.
Capsule Women with myotonic dystrophy type I have reduced ovarian reserve and respond poorly to controlled ovarian stimulation, though
there is no impact on oocyte quality. 相似文献
993.
Miyamoto T Koh E Sakugawa N Sato H Hayashi H Namiki M Sengoku K 《Journal of assisted reproduction and genetics》2008,25(11-12):553-557
Purpose
To investigate whether defects in human PRDM9, CDK2 and PSMC3IP are associated with azoospermia Mutational analysis was performed in Japanese patients with azoospermia caused by meiotic arrest.Methods
Mutational screening of the coding regions of human PRDM9, CDK2 and PSMC3IP was done by direct sequencing using genomic DNA from 18 Japanese patients. Statistical analysis of the detected coding single nucleotide polymorphisms (cSNPs) in patients and normal control men was then carried out.Results
One cSNP was detected in CDK2 and PSMC3IP. There were no significant differences in genotype distribution and allele frequencies between the patient and control groups in these two genes. However, three novel cSNPs were detected in the PRDM9. The genotype and allele frequencies of heterozygotes in SNP2 and SNP3 of PRDM9 were significantly higher in the patient group than in the control group.Conclusion
We found a possible association between PRDM9 and azoospermia by meiotic arrest.994.
Matsuura T Takehara Y Kaijima H Teramoto S Kato O 《Journal of assisted reproduction and genetics》2008,25(4):163-167
Purpose Although many reports support stimulated in vitro fertilization, several patients do not respond to it well. Furthermore,
stimulated treatment could be associated with reduced ovarian response. We describe three successful cases involving patients
of advanced age from whom dominant follicles were retrieved during the natural cycle.
Materials and methods All patients had failed to bear children through stimulated in vitro fertilization. In case 1, a follicle was retrieved after
a gonadotropin-releasing hormone agonist was used to induce luteinizing hormone surge. In cases 2 and 3, pregnancy was achieved
via completely natural cycles.
Results One embryo was transferred every 16 cycles. Ongoing pregnancy—defined as pregnancy progressing beyond gestation week 9—was
established in three cycles. The patients successfully delivered and had uneventful neonatal courses.
Conclusion Mature oocyte retrieval followed by natural rather than stimulated in vitro fertilization might be a potential treatment for
patients of advanced age when stimulated in vitro fertilization has been repeatedly unsuccessful.
Capsule We describe three successful pregnancies and deliveries achieved via natural IVF cycles: the patients were older than 37 years
with repeated failures by stimulated IVF. 相似文献
995.
Schmid M Schneitter A Hinterberger S Seeber J Reinthaller A Hefler L 《Obstetrics and gynecology》2007,110(6):1231-1236
OBJECTIVE: To evaluate whether C-reactive protein (CRP) serum levels are associated with prognosis in surgically treated endometrial cancer. METHODS: In the present multicenter study, CRP serum levels were measured preoperatively in 403 surgically staged patients with endometrioid endometrial cancer. Results were correlated to clinical data. RESULTS: The mean (standard deviation) serum CRP level in patients with endometrial cancer was 1.0 (1.8) mg/dL. Serum CRP levels were associated with tumor stage (P=.01), but not with tumor grade (P=.8), lymph node involvement (P=.8), and age at diagnosis (P=.9). In a univariable survival analysis, serum CRP levels, tumor stage, tumor grade, and age at diagnosis were associated with disease-free and overall survival (all P <.001). In a multivariable Cox regression model, serum CRP levels (P=.001, P=.004), tumor stage (P <.001, P <.001), tumor grade (P=.02, P=.009), and age at diagnosis (P=.002, P=.001) were independent prognostic factors for disease-free and overall survival. CONCLUSION: Our results suggest that elevated serum CRP levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer. LEVEL OF EVIDENCE: II. 相似文献
996.
997.
998.
Schmidt P Pruggmayer M Steinborn A Schippert C Staboulidou I Hillemanns P Scharf A 《Archives of gynecology and obstetrics》2007,276(3):259-262
Introduction First-trimester screening according to Nicolaides uses maternal age to obtain a common background risk for trisomy 21. The
likelihood ratios by nuchal translucency, free β-human chorionic gonadotropin and pregnancy-associated plasma protein-A are
not with respect to maternal age. It was the aim of this study to investigate if likelihood ratios should better take care
of it.
Materials Pearson’s correlation and different models of regression analysis had been performed on the results of 8,116 first-trimester
screenings. The total number of pregnancies was subdivided into three subgroups of healthy fetuses (n = 8,038); fetuses with Down’s syndrome (n = 46) and fetuses with other genetic abnormalities (n = 32). Statistical testing was applied to each of the three groups.
Results Strong independence from maternal age could be found for each of the first-trimester screening measurement parameter, as well
for healthy and as for affected fetuses. Neither Pearson’s test nor nonlinear regression models could detect a correlation.
Accordingly significance of Pearson’s test is not given.
Discussion First-trimester screening would not be improved by considering the maternal age in the calculation of the likelihood ratios.
Therefore the currently used algorithm is adequate. According, to the results, it seems to be proper as well to disregard
the maternal age in newer test strategies advanced first-trimester screening (AFS) at all. 相似文献
999.
Hermans C 《Archives of gynecology and obstetrics》2007,276(3):271-276
Backgroud Hereditary angioedema (HAE) is a rare genetic disorder caused by a deficiency of the plasma protein C1 inhibitor (C1-INH).
HAE is characterised by the onset of angioedema, which may develop in one or several organs, and may last from a few hours
to several days. Oedema of the upper airway can be life-threatening. As a result of hormonal changes, some women experience
more frequent angioedema attacks during pregnancy. During pregnancy, antifibrinolytic agents should only be used with caution,
and attenuated androgens are contraindicated; therefore, replacement therapy with C1-INH concentrate represents one of few
therapeutic options, but it is not widely documented.
Case study We report the first case study of the successful management with regular infusions of C1-INH concentrate, of two successive
pregnancies in a patient with HAE. During the second half of the first pregnancy, C1-INH was administered on demand at home.
For the second pregnancy, on demand treatment was intensified to prophylactic therapy, with once or twice weekly infusions
from the middle of the second trimester in order to efficiently control the frequent attacks.
Conclusions This report illustrates that HAE can be successfully managed during pregnancy with C1-INH infusions at home. Since the number
of crises may vary between pregnancies, the treatment regimen must be adapted to the patient’s need. 相似文献
1000.
Srivastava G Pilkington A Nallala D Polson DW Holt E 《Archives of gynecology and obstetrics》2007,276(5):555-557
Objective Ogilvies syndrome (OS) is a rare condition in obstetrics but occurs most commonly after caesarean section. Mortality rates
from OS can be as high as 36–50% when bowel perforation or ischemia develops which highlights the early recognition of this
condition. Early diagnosis is therefore essential to prevent serious morbidity and mortality.
Conclusion We, therefore report a case of OS after caesarean section in which early detection by senior clinicians resulted in successful
management of the condition and an excellent outcome. 相似文献