全文获取类型
收费全文 | 48篇 |
免费 | 0篇 |
专业分类
基础医学 | 4篇 |
临床医学 | 5篇 |
内科学 | 26篇 |
神经病学 | 2篇 |
外科学 | 1篇 |
药学 | 10篇 |
出版年
2022年 | 2篇 |
2021年 | 1篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2014年 | 3篇 |
2013年 | 2篇 |
2012年 | 1篇 |
2011年 | 3篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 7篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2004年 | 2篇 |
2003年 | 1篇 |
2002年 | 1篇 |
1998年 | 1篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1986年 | 1篇 |
1972年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有48条查询结果,搜索用时 15 毫秒
21.
Sigita Glaveckaite Karolina Lusaite Virginija Grabauskiene Nomeda Valeviciene Aleksandras Laucevicius 《Central European Journal of Medicine》2014,9(3):508-512
In this case report we describe the delayed diagnosis of a very rare congenital anomaly — isolated partial anomalous pulmonary venous connection. This congenital anomaly should be suspected at any age in the clinical setting of right heart volume overload, especially in the absence of a large atrial septal defect. Tomographic imaging modalities (computed tomography or cardiovascular magnetic resonance) not only allow the comprehensive structural and functional assessment of this anomaly, but also help assess the patient’s suitability for surgical treatment. Surgery is the definitive treatment of a patient with a significant left-to-right shunt due to partial anomalous pulmonary venous connection. 相似文献
22.
23.
Grupo de trabajo de la Sociedad Europea de Cardiología Alfonso F Ambrosio G Pinto FJ Van der Wall EE Kondili A Nibouche D Adamyan K Huber K Ector H Masic I Tarnovska R Ivanusa M Stanĕk V Videbaek J Hamed M Laucevicius A Mustonen P Artigou JY Cohen A Rogava M Böhm M Fleck E Heusch G Klawki R Vardas P Stefanadis C Tenczer J Chiariello M Elias J Benjelloun H Rødevand O Kułakowski P Apetrei E Lusov VA Oganov RG Obradovic V Kamensky G Kenda MF Höglund C Lüscher TF Lerch R Jokhadar M Haouala H 《Revista espa?ola de cardiología》2008,61(6):644-650
24.
Jelena Celutkiene George R Sutherland Aleksandras Laucevicius Diana Zakarkaite Alfredas Rudys Virginija Grabauskiene 《European heart journal》2004,25(11):932-942
AIMS: Doppler myocardial imaging (DMI) has been suggested as a method of quantifying induced ischaemia during dobutamine stress echocardiography (DSE). The aim of the present study was to investigate both standard systolic and diastolic parameters, but more specifically to address the phenomenon of post-systolic motion (PSM) as a marker of acquired ischaemia during DSE using pulsed-wave DMI. METHODS AND RESULTS: We examined 60 patients without previous myocardial infarction who underwent DSE. Peak systolic, post-systolic, early and late diastolic velocities were measured at rest and during stress. Myocardial segments (n = 908) were divided into ISCHAEMIC and NON-ISCHAEMIC groups according to the presence of significant angiographic coronary stenosis. ISCHAEMIC segments (n = 357) compared with NON-ISCHAEMIC segments (n = 551) demonstrated a reduced increase of systolic velocity (8.0-12.7 vs 9.3-16.4 cm/s, P < 0.05), prominent PSM (5.8-8.3 vs 0.63-2.1 cm/s, P < 0.000001) and reduced early diastolic velocity (6.5-10.2 vs 7.9-13.2 cm/s, P < 0.04) during stress. The peak velocity of PSM was the most accurate index of induced ischaemia (sensitivity 73-100%, specificity 82-97%) compared to systolic and early diastolic velocities (sensitivity 52-77% and 63-68%, specificity 63-77% and 59-81%, respectively). CONCLUSION: PSM derived by pulsed-wave DMI during DSE was the most sensitive index of acquired ischaemia compared to other functional DMI indices. 相似文献
25.
26.
Georgios?TsivgoulisEmail author Aristeidis?H.?Katsanos Pavla?Kadlecová Anna?Czlonkowska Adam?Kobayashi Miroslav?Brozman Viktor??vigelj Laszlo?Csiba Klara?Fekete Janika?K?rv Vida?Demarin Aleksandras?Vilionskis Dalius?Jatuzis Yakup?Krespi Chrissoula?Liantinioti Sotirios?Giannopoulos Robert?Mikulik 《Journal of neurology》2017,264(5):912-920
As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset (“golden hour”), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(?)] the “golden hour” by analyzing propensity score matched data from the SITS-EAST registry. Clinical recovery (CR) at 2 and 24 h was defined as a reduction of ≥10 points on NIHSS-score or a total NIHSS-score of ≤3 at 2 and 24 h, respectively. A relative reduction in NIHSS-score of ≥40% at 2 h was considered predictive of complete recanalization (CREC). Symptomatic intracranial hemorrhage (sICH) was defined using SITS-MOST criteria. Favorable functional outcome (FFO) was defined as a mRS-score of 0–1 at 3 months. Out of 19,077 IVT-treated AIS patients, 71 GH(+) patients were matched to 6882 GH(?) patients, with no differences in baseline characteristics (p > 0.1). GH(+) had higher rates of CR at 2 (31.0 vs. 12.4%; p < 0.001) and 24 h (41 vs. 27%; p = 0.010), CREC at 2 h (39 vs. 21%; p < 0.001) and FFO (46.5 vs. 34.0%; p = 0.028) at 3 months. The rates of sICH and 3-month mortality did not differ (p > 0.2) between the two groups. GH(+) was associated with 2-h CR (OR: 5.34; 95% CI 2.53–11.03) and CREC (OR: 2.38; 95% CI 1.38–4.09), 24-h CR (OR: 1.88; 95% CI 1.08–3.26) and 3-month FFO (OR: 2.02; 95% CI 1.15–3.54) in multivariable logistic regression models adjusting for potential confounders. In conclusion, AIS treated with IVT within the GH seems to have substantially higher odds of early neurological recovery, CREC, 3-month FFO and functional improvement. 相似文献
27.
Alfonso F Ambrosio G Pinto FJ Van der Wall EE;Task Force of the European Society of Cardiology Kondili A Nibouche D Adamyan K Huber K Ector H Masic I Tarnovska R Ivanusa M Stanek V Videbaek J Hamed M Laucevicius A Mustonen P Cohen JY Rogava M Böhm M Fleck E Heusch G Klawki R Vardas P Stefanadis C Tenczer J Chiariello M Elias J Benjelloun H Rødevand O Kułakowski P Apetrei E Lusov VA Oganov RG Obradovic V Kamensky G Kenda MF Höglund C Lüscher TF Lerch R Jokhadar M Haouala H Sansoy V Shumakov V 《Heart (British Cardiac Society)》2008,94(6):e19
28.
Gumbiene L Petrulioniene Z Rucinskas K Maneikiene V Serpytis P Dranenkiene A Laucevicius A 《Respiratory care》2011,56(11):1844-1848
We report a very rare case of severe pulmonary arterial hypertension in a patient with neurofibromatosis type 1, and discuss the pathology, pathogenesis, current pulmonary hypertension classification system, and outcomes of pulmonary arterial hypertension in patients with neurofibromatosis type 1. 相似文献
29.
Sigita Glaveckaite Nomeda Valeviciene Darius Palionis Viktor Skorniakov Jelena Celutkiene Algirdas Tamosiunas Giedrius Uzdavinys Aleksandras Laucevicius 《Journal of cardiovascular magnetic resonance》2011,13(1):1-12
Background
This study sought to prospectively and directly compare three cardiovascular magnetic resonance (CMR) viability parameters: inotropic reserve (IR) during low-dose dobutamine (LDD) administration, late gadolinium enhancement transmurality (LGE) and thickness of the non-contrast-enhanced myocardial rim surrounding the scar (RIM). These parameters were examined to evaluate their value as predictors of segmental left ventricular (LV) functional recovery in patients with LV systolic dysfunction undergoing surgical or percutaneous revascularisation. The second goal of the study was to determine the optimal LDD-CMR- and LGE-CMR-based predictor of significant (≥ 5%) LVEF improvement 6 months after revascularisation.Methods
In 46 patients with chronic coronary artery disease (CAD) (63 ± 10 years of age, LVEF 35 ± 8%), wall motion and the above mentioned CMR parameters were evaluated before revascularisation. Wall motion and LGE were repeatedly assessed 6 months after revascularisation. Logistic regression analysis models were created using 333 dysfunctional segments at rest.Results
An LGE threshold value of 50% (LGE50) and a RIM threshold value of 4 mm (RIM4) produced the best sensitivities and specificities for predicting segmental recovery. IR was superior to LGE50 for predicting segmental recovery. When the areas under the ROC curves is compared, the combined viability prediction model (LGE50 + IR) was significantly superior to IR alone in all analysed sets of segments, except the segments with an LGE from 26% to 75% (p = 0.08). The RIM4 model was not superior to the LGE50 model. A myocardial segment was considered viable if it had no LGE or had any LGE and produced IR during LDD stimulation. ROC analysis demonstrated that ≥ 50% of viable segments from all dysfunctional and revascularised segments in a patient predict significant improvement in LVEF with a 69% sensitivity and 70% specificity (AUC 0.7, p = 0.05). The cut-off of ≥ 3 viable segments was a less useful predictor of significant global LV recovery.Conclusions
LDD-CMR is superior to LGE-CMR as a predictor of segmental recovery. The advantage is greatest in the segments with an LGE from 26% to 75%. The RIM cut-off value of 4 mm had no superiority over the LGE cut-off value of 50% in predicting the segmental recovery. Patients with ≥ 50% of viable segments from all dysfunctional and revascularised had a tendency to improve LVEF by ≥ 5% after revascularisation. 相似文献30.
Aleksandras Rybakovas Kęstutis Arbačiauskas Vaida Markovskienė Kęstutis Jokšas 《Environmental and molecular mutagenesis》2020,61(3):338-354
European inland waters are under continuous threat of anthropogenic pollution. Determination of background level of biomarker response and subsequent classification of the impact increases the applicability of results. In the current study, we evaluate the range of chemical contamination by measuring the concentrations of metals, polycyclic aromatic hydrocarbons and polychlorinated biphenyls, and the levels of environmental genotoxicity by using the micronuclei and nuclear bud tests in bivalve mussels of the major Lithuanian rivers. Second, we aimed to evaluate the association between chemical contamination and genotoxicity biomarker responses. Finally, we set to determine the background level of genotoxic effects. Such value (summed frequency of MN and NB) was assessed—6‰. On that basis, we develop a scale of potential genotoxic impact and perform ranging sites into five categories. The results clearly indicate the existence of significant differences in the levels of chemical pollution and genotoxicity in different sites. Increased levels of studied parameters were assessed at the areas affected by municipal and industrial effluents, road runoff, combustion products, and in the area contaminated by accidental spillage. On the other hand, downstream decrease of contamination level, presumably associated with biological degradation and photochemical oxidation, were also observed. Genotoxicity parameters were associated with PAH and metal concentrations measured in mussel tissues as well as in sediments. Results also indicate that in situ genotoxicity assessment performed in the areas affected by long-term contamination of municipal origin might be not sufficiently precise. Study highlights the necessity to combine genotoxicity assessment with chemical analysis. Environ. Mol. Mutagen. 61:338–354, 2020. © 2019 Wiley Periodicals, Inc. 相似文献