全文获取类型
收费全文 | 55355篇 |
免费 | 2724篇 |
国内免费 | 281篇 |
专业分类
耳鼻咽喉 | 450篇 |
儿科学 | 1032篇 |
妇产科学 | 664篇 |
基础医学 | 7429篇 |
口腔科学 | 1392篇 |
临床医学 | 3629篇 |
内科学 | 14229篇 |
皮肤病学 | 1297篇 |
神经病学 | 4055篇 |
特种医学 | 2171篇 |
外科学 | 9220篇 |
综合类 | 257篇 |
一般理论 | 1篇 |
预防医学 | 1689篇 |
眼科学 | 1133篇 |
药学 | 3669篇 |
中国医学 | 102篇 |
肿瘤学 | 5941篇 |
出版年
2023年 | 272篇 |
2022年 | 591篇 |
2021年 | 1033篇 |
2020年 | 530篇 |
2019年 | 715篇 |
2018年 | 1001篇 |
2017年 | 783篇 |
2016年 | 937篇 |
2015年 | 983篇 |
2014年 | 1367篇 |
2013年 | 1624篇 |
2012年 | 2641篇 |
2011年 | 2992篇 |
2010年 | 1627篇 |
2009年 | 1510篇 |
2008年 | 2651篇 |
2007年 | 2879篇 |
2006年 | 2944篇 |
2005年 | 3034篇 |
2004年 | 2941篇 |
2003年 | 3055篇 |
2002年 | 3013篇 |
2001年 | 1710篇 |
2000年 | 1667篇 |
1999年 | 1553篇 |
1998年 | 841篇 |
1997年 | 632篇 |
1996年 | 597篇 |
1995年 | 514篇 |
1994年 | 463篇 |
1993年 | 434篇 |
1992年 | 1067篇 |
1991年 | 945篇 |
1990年 | 854篇 |
1989年 | 852篇 |
1988年 | 786篇 |
1987年 | 779篇 |
1986年 | 700篇 |
1985年 | 662篇 |
1984年 | 463篇 |
1983年 | 380篇 |
1982年 | 231篇 |
1981年 | 207篇 |
1980年 | 189篇 |
1979年 | 292篇 |
1978年 | 228篇 |
1977年 | 199篇 |
1975年 | 183篇 |
1974年 | 181篇 |
1973年 | 192篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
992.
993.
Akira Horikawa Yuji Kasukawa Michio Hongo Hiroyuki Kodama Akihisa Sano Naohisa Miyakoshi 《Medicine》2022,101(43)
Although osteoporotic patients have already been recognized as having a low-volume vitamin D status, the concentration of active vitamin D precursor has not been studied in detail. This trial aimed to clarify the concentration of 25-hydroxyvitamin D (25-OHD), which is a natural type of vitamin D and compare between 2 separate areas in Japan. To compare and clarify the concentration of 25-OHD between 2 separate areas, Japanese patients who were diagnosed as having osteoporosis based on bone mineral density were studied. We analyzed 2 different hospitals’ patients whose residence is separated into a northern district (Akita city: north latitude 39” 43’) and a southern district (Shizuoka city: north latitude 34” 58’). Both of them have completely different daylight hours. Three-hundred sixty eight patients (174 in Akita, 194 in Shizuoka) were enrolled in this trial to compare the differences of concentration of 25-OHD by Welch’s t t-test. There were significant differences in the concentration of 25-OHD and age between them. Akita patients were significantly higher than that of Shizuoka patients despite Shizuoka having much daylight hours of Akita. In conclusion, there might be no relationship between the concentration of 25 OHD and exposure to sunlight. 相似文献
994.
995.
Kuniko Sato Fumihiko Suzuki Hiromasa Tsujiguchi Akinori Hara Takayuki Kannon Sakae Miyagi Keita Suzuki Masaharu Nakamura Chie Takazawa Aki Shibata Hirohito Tsuboi Yukari Shimizu Thao Thi Thu Nguyen Tadashi Konoshita Yasuki Ono Koichi Hayashi Atsushi Tajima Hiroyuki Nakamura 《Nutrients》2022,14(23)
Epidemiological studies reported that resilience, generally regarded as the ability to manage stress in the face of adversity, correlates with mental health in middle-aged and older adults. Currently, there is limited information on eating habits that affect resilience. Therefore, this cross-sectional study investigated the relationship between vitamin intake and resilience based on sex in community-dwelling middle-aged and older individuals in Shika town, Ishikawa Prefecture, Japan. A total of 221 participants (106 men and 115 women) aged 40 years or older were included in the analysis. We assessed vitamin intake and resilience using a brief-type self-administered diet history questionnaire (BDHQ) and the resilience scale (RS), respectively. A two-way analysis of covariance (ANCOVA) revealed that higher intakes of β-carotene and vitamin K were associated with higher RS in women, but not in men. Furthermore, a multiple logistic regression analysis stratified by sex showed that β-carotene and vitamin K were significant independent variables for RS only in women. The present study suggests that higher intakes of β-carotene and vitamin K were associated with higher resilience among middle-aged and older women. The results obtained demonstrate that β-carotene and vitamin K intakes may enhance resilience by strengthening stress tolerance. 相似文献
996.
Akira Tempaku 《Journal of Rural Medicine》2022,17(4):265
Objective: Medication-resistant essential tremor requires surgical treatment. Deep brain stimulation to the thalamic ventral intermediate nucleus is an established procedure to diminish tremors. Tremor on both sides needs dual deep brain stimulation implantation. Nowadays, magnetic resonance-guided focus ultrasound is broaden to treat essential tremor. However, the safety of magnetic resonance-guided focus ultrasound against dual ventral intermediate is still under discussion, since bilateral thalamotomy causes speech disturbance or ataxia.Patient and Methods: A 66-year-old right-handed man had medication-resistant essential tremor at bilateral upper extremities superior to the left arm. A treatment of magnetic resonance-guided focus ultrasound was performed by using the ExAblate transcranial system against the left ventral intermediate. One year after magnetic resonance-guided focus ultrasound treatment, the stereotactic implantation of a deep brain stimulation electrode into the right ventral intermediate was done.Results: Clinical rating scale for tremor in the right arm was reduced from 12 to 0 points by magnetic resonance-guided focus ultrasound against the left ventral intermediate. The clinical rating scale for tremor in the left arm was reduced from 23 to 1 point by deep brain stimulation to the right ventral intermediate.Conclusion: Hybrid surgery of magnetic resonance-guided focus ultrasound and deep brain stimulation refined bilateral essential tremor, without any neurological deficiencies. This combined surgery would be useful to manage medication-resistant bilateral essential tremor patients who are carrying some difficulties to introduce deep brain stimulation on the bilateral side. 相似文献
997.
Makiko Nakamura Teruhiko Imamura Takuya Fukui Naoya Kataoka Koichiro Kinugawa 《Internal medicine (Tokyo, Japan)》2022,61(20):3063
Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) classically present with ventricular arrhythmias and less commonly heart failure. ARVC is an inherited cardiomyopathy and generally based on a variant of desmosomal genes. Recently, the association between myocardial inflammation and ARVC has been a matter of great concern. We encountered a patient with ARVC who had a desmoglein-2 mutation with advanced right ventricular failure accompanying a preserved left ventricular function. Concomitant right ventricular myocarditis was detected four years after the diagnosis of ARVC. ARVC and myocarditis might have a deep pathophysiological association, at least in some cases. 相似文献
998.
Ikuro Matsuba Tetsuo Takuma Nobuo Hatori Masahiko Takai Yoshiyuki Watanabe Nobukazu Takada Satoru Kishi Yoko Matsuzawa Tetsuo Nishikawa Tomoyuki Kunishima Hisakazu Degawa Masanori Nishikawa Yoshiaki Ono Masaaki Miyakawa Yutaka Hatori Akira Kanamori 《Internal medicine (Tokyo, Japan)》2022,61(20):3053
Objective To examine the continuation of antibody prevalence status after 12 months and background factors in antibody-positive subjects following asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We initially determined the SARS-CoV-2 anti-nucleocapsid protein immunoglobulin G (anti-N IgG) antibody prevalence in 1,603 patients, doctors, and nurses at 65 medical institutions in Kanagawa Prefecture, Japan. We then obtained consent from 33 of the 39 subjects who tested positive and performed follow-up for 12 months. Results Follow-up for up to 12 months showed that a long-term response of the anti-N IgG antibody could be detected in 6 of the 33 participants (18.2%). The proportions with hypertension, using an angiotensin-receptor blocker, and without a drinking habit were higher among the participants with a long-term anti-N IgG antibody response for up to 12 months than among those without a long-term antibody response. Conclusions The proportion of individuals with subclinical COVID-19 who continuously had a positive result for the anti-N IgG antibody at 12 months was low. 相似文献
999.
Ryo Yanagiya Masahiro Wanezaki Naohisa Nakamura Tsubasa Ichikawa Tatsuya Hayasaka Akane Yamada Keiko Aizawa Satoshi Ito Masahito Himuro Hiroto Suzuki Masakazu Yamamoto Tomomi Toubai Masafumi Watanabe Kenichi Ishizawa 《Internal medicine (Tokyo, Japan)》2022,61(18):2779
Cardiotoxicity is a critical complication of allogeneic hematopoietic cell transplantation (allo-HCT). In particular, management of severe cardiotoxicity occurring in the early phases of allo-HCT is challenging. We encountered a case of severe cardiotoxicity resulting from AHF six days after allo-HCT, which resisted catecholamines and diuretics. The patient was treated with anthracycline-containing regimens and underwent myeloablative conditioning, including high-dose cyclophosphamide. As invasive circulatory assisting devices were contraindicated because of his immunocompromised status and bleeding tendency, we successfully treated the patient with ivabradine-containing medications. Ivabradine may therefore be considered an alternative drug for the treatment of severe cardiotoxicity induced by cytotoxic agents. 相似文献
1000.
Noriaki Kawano Shunou Nakamura Kousuke Mochida Shuro Yoshida Takuro Kuriyama Takashi Nakaike Tomonori Shimokawa Taro Tochigi Kiyoshi Yamashita Koichi Mashiba Ikuo Kikuchi Aina Takarabe Sayaka Moriguchi Yasuo Mori Katsuto Takenaka Kazuya Shimoda Hidenobu Ochiai Masahiro Amano 《Internal medicine (Tokyo, Japan)》2022,61(18):2771
Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer. 相似文献