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21.
Zahra Hassannejad Shayan Abdollah Zadegan Alexander R. Vaccaro Vafa Rahimi-Movaghar Omid Sabzevari 《Injury》2019,50(2):278-285
Background
The complex pathophysiological events occurring after traumatic spinal cord injuries (TSCI) make this devastating trauma still incurable. Peptide amphiphile (PA) hydrogels are nanobiomaterials displaying desirable properties for application in regenerative medicine because they are absorbable, injectable, allowing biofunctionalization, controlling release of trophic factors and mimic extracellular matrix (ECM). In this study, we explored the potentiality of the IKVAV-functionalized PA hydrogel to provide a permissive environment for cell migration and growth as well as sustained release of BDNF at the lesion after severe compression injury model.Methods
The IKVAV-functionalized PA was synthesized by automated solid-phase approach and its secondary structure was evaluated by Circular dichroism (CD) spectroscopy. The potential of IKVAV-functionalized PA to self-assemble into nanofibers and hydrogel formation were assessed using transmission electron microscopy (TEM). Release profiles of BDNF from hydrogel and the bioactivity of the released BDNF from hydrogel were determined using ELISA and DRG bioassay, respectively. Severe spinal cord injury was induced using clip compression at T7-T8 vertebral segment. Twenty four hours post-injury the animals were treated by either IKVAV PA hydrogel, BDNF-loaded IKVAV PA hydrogel, BDNF solution or saline. Two and six weeks later, animals were sacrificed and the lesion site was evaluated based on GFAP, CD68 and ß III tubulin immunoreactivity. Also, locomotor recovery was assessed during 6 weeks using Basso, Beattie, Bresnahan (BBB) scoring test.Results
The IKVAV PA arranged into nanofibrous structure and provided a sustained release of BDNF over 21 days while preserved the bioactivity of BDNF. Also, BDNF loading influenced the hydrogel nanostructure resulting in aligned orientation of nanofibers. Injection of BDNF-loaded IKVAV PA hydrogel resulted in a considerable axon preservation and astrogliosis reduction at 6 weeks post-injury without showing any inflammatory reaction. However, the BBB score was not statistically different between different treatment groups.Conclusion
Although the locomotor functional recovery was not observed in this study, the axon preservation and minimal inflammation in animals treated with BDNF-incorporated hydrogel indicate the potentiality of the designed intervention for further evaluations in the path of developing efficient therapies for severe spinal cord injury. 相似文献22.
Reza Rostami Payman Salamati Kourosh Karimi Yarandi Alireza Khoshnevisan Soheil Saadat Zeynab Sadat Kamali Somaie Ghiasi Atefeh Zaryabi Seyed Shahab Ghazi Mir Saei Mehdi Arjipour Mohammad Saeid Rezaee-Zavareh Vafa Rahimi-Movaghar 《中华创伤杂志(英文版)》2017,20(5):278-282
Purpose: There are some studies which showed neurofeedback therapy (NFT) can be effective in clients
with traumatic brain injury (TBI) history. However, randomized controlled clinical trials are still needed
for evaluation of this treatment as a standard option. This preliminary study was aimed to evaluate the
effect of NFT on continuous attention (CA) and short-term memory (STM) of clients with moderate TBI
using a randomized controlled clinical trial (RCT).
Methods: In this preliminary RCT, seventeen eligible patients with moderate TBI were randomly allocated in two intervention and control groups. All the patients were evaluated for CA and STM using the
visual continuous attention test and Wechsler memory scale-4th edition (WMS-IV) test, respectively,
both at the time of inclusion to the project and four weeks later. The intervention group participated in
20 sessions of NFT through the first four weeks. Conversely, the control group participated in the same
NF sessions from the fifth week to eighth week of the project.
Results: Eight subjects in the intervention group and five subjects in the control group completed the
study. The mean and standard deviation of participants'' age were (26.75 ± 15.16) years and (27.60 ± 8.17)
years in experiment and control groups, respectively. All of the subjects were male. No significant
improvement was observed in any variables of the visual continuous attention test and WMS-IV test between two groups (p≥0.05).
Conclusion: Based on our literature review, it seems that our study is the only study performed on the effect of NFT on TBI patients with control group. NFT has no effect on CA and STM in patients with moderate TBI. More RCTs with large sample sizes, more sessions of treatment, longer time of follow-up and different protocols are recommended. 相似文献
23.
Elham Pishbin Koorosh Ahmadi Molood Foogardi Maryam Salehi Farrokh Seilanian Toosi Vafa Rahimi-Movaghar 《中华创伤杂志(英文版)》2017,20(4):226-228
Purpose: Rib fractures are the most common skeletal thoracic injuries resulting from blunt chest trauma. Half of the rib fractures are not detected upon a precise physical evaluation and radiographs. Recently ultrasonography (USG) has been investigated to detect rib fractures. But based on literature the usefulness of USG varies widely. This study was conducted to investigate the role of USG in the detection of possible rib fractures in comparison with radiography.
Methods: In this cross-sectional study, consecutive patients with minor blunt chest trauma and suspected rib fractures presenting in Imam Reza Hospital located in Mashhad-Iran, between April 2013 and October 2013 were assessed by USG and radiography. The radiography was performed in a posteroanterior (PA) chest projection and oblique rib view centered over the area of trauma. The time duration spent in taking USG and radiography were recorded. The prevalence and location of fractures revealed by USG and radiography were compared.
Results: Sixty-one suspected patients were assessed. The male to female ratio was 2.4:1 (43 men and 18 women) with a mean ± SD age of (44.3 ± 19.7) years. There were totally 59 rib fractures in 38 (62.3%) patients based on radiography and USG, while 23 (37.7%) patients had no diagnostic evidence of rib lesions. USG revealed 58 rib fractures in 33 (54.1%) of 61 suspected patients and radiographs revealed 32 rib fractures in 20 (32.8%) of 61 patients. A total of 58 (98.3%) rib fractures were detected by USG,
whereas oblique rib view and PA chest radiography showed 27 (45.8%) and 24 (40.7%) rib fractures, respectively. The average duration of USG was (12 ± 3) min (range 7e17 min), whereas the duration of radiography was (27 ± 6) min (range 15-37 min). The kappa coefficient showed a low level of agreement between both USG and PA chest radiography (kappa coefficient=0.28), and between USG and oblique rib view (kappa coefficient=0.32).
Conclusion: USG discloses more fractures than radiography in most patients presenting with suspected rib fractures. Moreover USG requires significantly less time than radiography. 相似文献
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Jesús Castro-Calvo Daniel L. King Dan J. Stein Matthias Brand Lior Carmi Samuel R. Chamberlain Zsolt Demetrovics Naomi A. Fineberg Hans-Jürgen Rumpf Murat Yücel Sophia Achab Atul Ambekar Norharlina Bahar Alexander Blaszczynski Henrietta Bowden-Jones Xavier Carbonell Elda Mei Lo Chan Chih-Hung Ko Philippe de Timary Magali Dufour Marie Grall-Bronnec Hae Kook Lee Susumu Higuchi Susana Jimenez-Murcia Orsolya Király Daria J. Kuss Jiang Long Astrid Müller Stefano Pallanti Marc N. Potenza Afarin Rahimi-Movaghar John B. Saunders Adriano Schimmenti Seung-Yup Lee Kristiana Siste Daniel T. Spritzer Vladan Starcevic Aviv M. Weinstein Klaus Wölfling Joël Billieux 《Addiction (Abingdon, England)》2021,116(9):2463-2475
26.
Heidari Pedram Zarei Mohammad Reza Rasouli Mohammad Reza Alexander R Vaccaro Rahimi-Movaghar Vafa 《中华创伤杂志(英文版)》2010,13(1):3-9
Objective: To illustrate mechanisms of spine fractures and the pattern of spinal injuries characterized by the major mechanisms in urban population of Iran. Methods: Data regarding spinal injuries including demographics, mechanism and level of spinal injury, abbreviated injury score, associated injuries and final fate of the patients were extracted from the Iranian national trauma registry database from 1999 to 2004. Results: A total of 619 patients with traumatic spine fractures were identified, of whom 68.5% were males. The peak frequency of these injuries occurred in the 21-40 year age-group. Accidental falls and road traffic crashes (RTCs) were the most common mechanisms of spinal fractures (47.2% and 44.1%, respectively). RTCs tended to occur in younger patients compared with accidental falls. The most common spinal region for spinal fracture was the lumbar spine (53.63%). Cervical spine fractures were significantly more common in RTCs, while lumbar spine fractures were more common in accidental falls (P〈0.001). A total of 171 (27.6%)patients had associated non-spinal injuries, of whom 127 had associated extremity injuries, and 55 had head injuries. Thirty-six (5.6%) patients had spinal cord injury (SCI).The injury severity score of the RTC group was significantly higher than that of accidental falls (P=-0.002). Fifteen (4%) patients died of traumatic injuries. The rate of death was significantly higher in RTCs compared with accidental falls (5.1% vs 2.1%, P=0.039). Conclusions: The patterns of spinal fractures are similar to those reported from developed countries. RTCs tend to affect the younger age population and are associated with a higher degree of associated injuries and mortality than accidental falls. Therefore preventive strategies should be based on reduction of the number and severity of RTCs. 相似文献
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Randhawa P Farasati NA Shapiro R Hostetler KY 《Antimicrobial agents and chemotherapy》2006,50(4):1564-1566
Polyomavirus BK is a significant pathogen in transplant recipients, but no effective antiviral therapy is available. We show that cidofovir can inhibit BK virus replication in vitro. Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index. 相似文献
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Siavash Jafari Afarin Rahimi Movaghar Kevin Craib Souzan Baharlou Richard Mathias 《International journal of mental health and addiction》2009,7(2):376-388
This study aimed to identify socio-cultural factors facilitating initiation of opium use among drug users in Darab, Iran.
A qualitative study using in-depth interviews was conducted. The study began in June 2006 and included 76 drug users, aged
20–43, of whom 95% (72) were male, and 5% (4) were female. The five most common factors facilitating initiation of drug use
were revealed to be: lack of hobbies, treatment of general medical problems, modeling, peer networks, and cultural norms.
Partner pressure was a common complaint among women in this study. Cultural factors perceived to facilitate initiation of
drug use revealed in this study have not been fully addressed by current prevention and rehabilitation programs. Programs
can be targeted at social and family levels to alter drug use culture. 相似文献