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Meera Narasimhan Chi Un Pae Natasha Masand Prakash Masand 《International journal of psychiatry in clinical practice》2013,17(2):102-111
Partial compliance with antipsychotic medications is a common and complex phenomenon that is underestimated by physicians. The consequences of partial compliance include an increased risk of relapse, rehospitalization and suicide attempts. Stigma, negative attitudes towards medications, cognitive impairment and diminished insight negatively impact treatment adherence. Oral atypical antipsychotics may improve both insight and cognitive function, but compliance with these agents is not assured. Depot conventional antipsychotics ensure medication delivery but are associated with side-effects such as EPS and dysphoria that decrease compliance. Long-acting atypicals provide significant symptom improvement, foster adherence and may help achieve improvement in insight and cognition. Addressing issues of partial and non-compliance is a significant consideration in relapse prevention strategies for patients with schizophrenia, given the devastating consequences associated with psychotic relapses. 相似文献
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Alessandro Serretti Chiara Fabbri Silvia Pellegrini Stefano Porcelli Pierluigi Politi Silvio Bellino Marco Menchetti Veronica Mariotti Cristina Demi Valentina Martinelli Marco Cappucciati Paola Bozzatello Elena Brignolo Paolo Brambilla Chi-Un Pae Matteo Balestrieri Diana De Ronchi 《Psychiatry investigation》2013,10(2):180-189
Objective
Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated.Methods
One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417).Results
IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome.Conclusion
Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups. 相似文献54.
Carla Sustek D'Angelo Ilana Kohl Monica Castro Varela Cláudia Irene Emílio de Castro Chong Ae Kim Débora Romeo Bertola Charles Marques Lourenço Ana Beatriz Alvarez Perez Celia Priszkulnik Koiffmann 《American journal of medical genetics. Part A》2013,161(3):479-486
Obesity is a major threat to public health worldwide, and there is now mounting evidence favoring a role for the central nervous system (CNS) in weight control. A causal relationship has been recognized in both monogenic (e.g., BDNF, TRKB, and SIM1 deficiencies) and syndromic forms of obesity [e.g., Prader–Willi syndrome (PWS)]. Syndromic obesity arising from chromosomal abnormalities, that typically also affect learning and development, are often associated with congenital malformations and behavioral characteristics. We report on nine unrelated patients with a diagnosis of learning disability and/or developmental delay (DD) in addition to obesity that were found to have copy number variants (CNVs) by single nucleotide polymorphism array‐based analysis. Each patient also had a distinct and complex phenotype, and most had hypotonia and other neuroendocrine issues, such as hyperphagia and hypogonadism. Molecular and clinical characterization of these patients enabled us to determine with confidence that the CNVs we observed were pathogenic or likely to be pathogenic. Overall, the CNVs reported here encompassed a candidate gene or region (e.g., SIM1) that has been reported in patients associating obesity and DD and/or intellectual disability (ID) and novel candidate genes and regions. © 2013 Wiley Periodicals, Inc. 相似文献
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Hirotaka Koyanagi Keisuke Ae Hidetsugu Maehara Masato Yuasa Tomokazu Masaoka Tsuyoshi Yamada Takashi Taniyama Masanori Saito Yuki Funauchi Toshitaka Yoshii Atsushi Okawa Shinichi Sotome 《Journal of orthopaedic research》2013,31(8):1308-1316