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排序方式: 共有1413条查询结果,搜索用时 15 毫秒
61.
Roberto Romero Yi Xu Olesya Plazyo Piya Chaemsaithong Tinnakorn Chaiworapongsa Ronald Unkel Nandor Gabor Than Po Jen Chiang Zhong Dong Zhonghui Xu Adi L. Tarca Vikki M. Abrahams Sonia S. Hassan Lami Yeo Nardhy Gomez‐Lopez 《American journal of reproductive immunology (New York, N.Y. : 1989)》2018,79(6)
62.
Than NG Abdul Rahman O Magenheim R Nagy B Fule T Hargitai B Sammar M Hupuczi P Tarca AL Szabo G Kovalszky I Meiri H Sziller I Rigo J Romero R Papp Z 《Virchows Archiv : an international journal of pathology》2008,453(4):387-400
Placental protein 13 (PP13) is a galectin expressed by the syncytiotrophoblast. Women who subsequently develop preterm pre-eclampsia
have low first trimester maternal serum PP13 concentrations. This study revealed that third trimester maternal serum PP13
concentration increased with gestational age in normal pregnancies (p < 0.0001), and it was significantly higher in women presenting with preterm pre-eclampsia (p = 0.02) and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome (p = 0.01) than in preterm controls. Conversely, placental PP13 mRNA (p = 0.03) and protein, as well as cytoplasmic PP13 staining of the syncytiotrophoblast (p < 0.05) was decreased in these pathological pregnancies compared to controls. No differences in placental expression and
serum concentrations of PP13 were found at term between patients with pre-eclampsia and control women. In contrast, the immunoreactivity
of the syncytiotrophoblast microvillous membrane was stronger in both term and preterm pre-eclampsia and HELLP syndrome than
in controls. Moreover, large syncytial cytoplasm protrusions, membrane blebs and shed microparticles strongly stained for
PP13 in pre-eclampsia and HELLP syndrome. In conclusion, parallel to its decreased placental expression, an augmented membrane
shedding of PP13 contributes to the increased third trimester maternal serum PP13 concentrations in women with preterm pre-eclampsia
and HELLP syndrome. 相似文献
63.
Jonathan L. Curry Michael T. Tetzlaff Priyadharsini Nagarajan Carol Drucker Adi Diab Sharon R. Hymes Madeleine Duvic Wen‐Jen Hwu Jennifer A. Wargo Carlos A. Torres‐Cabala Ronald P. Rapini Victor G. Prieto 《Journal of cutaneous pathology》2017,44(2):158-176
Immunomodulatory drugs that leverages host immune mechanisms to destroy tumor cells have been met with great promise in the treatment of cancer. Immunotherapy, targeting cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4) and the programmed cell death 1 (PD‐1) receptor and its ligand (PD‐L1) have shown tremendous improvements in the survival of patients with advanced solid tumors. However, the development of dermatologic toxicity (DT) is a consequence to immunotherapy. Review of published reports of the DT to immunotherapy revealed patients receiving anti‐CTCLA‐4 antibody or anti‐PD‐1/PD‐L1 antibody often develop a DT of any type and grade. In this article, of the 3825 patients who were treated with anti‐PD‐1 and of 556 patients receiving anti‐PD‐L1, DT of any type and grade were reported in 1474 (~39%) and 95 (~17%) of patients, respectively. The emergence of specific types of DT to immunotherapy is beginning to be recognized can be categorized into four groups: (a) inflammatory, (b) immunobullous, (c) alteration of keratinocytes and (d) alteration of melanocytes. Lichenoid dermatitis and bullous pemphigoid appear to be DT more associated with anti‐PD‐1/PD‐L1 antibody. The DT profile in patients receiving immunotherapy is diverse, and early recognition of specific types of DT that clinicians may encounter is critical for optimal patient care 相似文献
64.
Non-occupational contact allergy to Laurus nobilis (laurel) oil is considered rare. Herein, we report a case of allergic contact dermatitis after a massage with a mixture of olive oil and L. nobilis oil. Patch testing showed (+++) reactions to laurel oil and (++) to the mixture of olive oil and laurel oil. 相似文献
65.
Yerushalmy A Reches A Lessing JB Schechner V Carmeli Y Grisaru D 《European journal of obstetrics, gynecology, and reproductive biology》2008,141(2):169-172
Objective
To characterize organisms causing wound infection following abdominal hysterectomy.Study design
All patients who underwent an abdominal hysterectomy (December 2002–January 2006) and developed abdominal wall wound infection proven by a positive culture were included in the study. Patient information was collected from the computerized files. The isolated microorganisms were characterized for antibiotics susceptibility.Results
Sixty-eight (68/620, 10.96%) patients had positive wound cultures. Of 100 isolated microorganisms, 44 were resistant to cefonicid (prophylactic treatment) and 15 were resistant to combined ampicillin, gentamicin and metronidazole (empirical treatment). Major co-morbidities (including diabetes mellitus, hypertension, past malignancies, renal, cardiovascular and pulmonary diseases, hypothyroidism or anemia), were found to be significantly associated with pseudomonal infection (P < .008).Conclusion
A significant portion of pathogens causing post-hysterectomy abdominal wall wound infection are resistant to the prophylactic treatment, and some are resistant to the empirical treatment. Further studies are necessary to evaluate the effectiveness of various prophylactic regimens with better coverage of Enterococcus fecalis, as well as the effectiveness of empirical treatment active against the resistant Enterobacteriaceae group. 相似文献66.
Adrian M. Dubuc Marc Remke Andrey Korshunov Paul A. Northcott Shing H. Zhan Maria Mendez-Lago Marcel Kool David T. W. Jones Alexander Unterberger A. Sorana Morrissy David Shih John Peacock Vijay Ramaswamy Adi Rolider Xin Wang Hendrik Witt Thomas Hielscher Cynthia Hawkins Rajeev Vibhakar Sidney Croul James T. Rutka William A. Weiss Steven J. M. Jones Charles G. Eberhart Marco A. Marra Stefan M. Pfister Michael D. Taylor 《Acta neuropathologica》2013,125(3):373-384
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69.
Yael Kuperman Orna Issler Limor Regev Ifat Musseri Inbal Navon Adi Neufeld-Cohen Shosh Gil Alon Chen 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(18):8393-8398
In response to physiological or psychological challenges, the brain activates behavioral and neuroendocrine systems linked to both metabolic and emotional outputs designed to adapt to the demand. However, dysregulation of integration of these physiological responses to challenge can have severe psychological and physiological consequences, and inappropriate regulation, disproportional intensity, or chronic or irreversible activation of the stress response is linked to the etiology and pathophysiology of mood and metabolic disorders. Using a transgenic mouse model and lentiviral approach, we demonstrate the involvement of the hypothalamic neuropeptide Urocortin-3, a specific ligand for the type-2 corticotropin-releasing factor receptor, in modulating septal and hypothalamic nuclei responsible for anxiety-like behaviors and metabolic functions, respectively. These results position Urocortin-3 as a neuromodulator linking stress-induced anxiety and energy homeostasis and pave the way toward better understanding of the mechanisms that mediate the reciprocal relationships between stress, mood and metabolic disorders. 相似文献
70.