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Peter Bergin Lynette Sadleir Benjamin Legros Zarine Mogal Manjari Tripathi Nitika Dang Simone Beretta Clara Zanchi Jorge Burneo Thomas Borkowski Yang Je Cho Michel Ossemann Pasquale Striano Kavita Srivastava Hui Jan Tan Jithangi Wanigasinghe Wendyl D’Souza for the EpiNet study group 《Epilepsia》2012,53(10):1829-1835
Purpose: We created an epilepsy patient database that can be accessed via the Internet by neurologists from anywhere in the world. The database was designed to enroll and follow large cohorts of patients with specific epilepsy syndromes, and to facilitate recruitment of patients for investigator‐initiated clinical trials. Methods: The EpiNet database records physician‐derived information regarding seizure type and frequency, epilepsy syndrome, etiology, drug history, and investigations. It can be accessed from any country by approved investigators via a secure, password‐protected Website. All data are encrypted. The database is for both research and clinical purposes. Investigators were invited to register any patient with epilepsy, but were particularly encouraged to register patients when uncertain of the optimal management. Participation required approval from investigators’ ethics committees and institutional review boards, and all patients or their caregiver provided written informed consent. Patients were not enrolled in clinical trials in this pilot study. Key Findings: The international pilot study recruited patients from September 2010 to November 2011. Sixty‐four investigators or research assistants from 25 centers in 13 countries registered 1,050 patients. Patients with a wide range of epilepsy syndromes and etiologies were registered. Patients’ ages ranged from 2 weeks to 90 years. Significance: The Website was successfully used by doctors working in different health systems. The pilot study confirmed that this low‐cost, collaborative approach to research has great potential. Large, multicenter cohort studies will commence in 2012, and randomized clinical trials are being planned. All epileptologists are invited to join this project. 相似文献
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Rathor Laxmi Pant Aakanksha Nagar Abhishek Tandon Sudeep Trivedi Shalini Pandey Rakesh 《Proceedings of the National Academy of Sciences, India. Section B.》2017,87(4):1355-1362
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - The use of herbs in the form of dietary supplements and medicine is fascinating the world, owing to their... 相似文献
65.
Singh Nisha Dhakad Amita Singh Uma A. K. Tripathi Sankhwar Pushplata 《Indian journal of hematology & blood transfusion》2012,28(2):77-81
To find the prevalence and causes of thrombocytopenia during pregnancy. An analytical prospective observational study was
conducted in Department of Obstetrics & Gynecology, CSMMU, Lucknow. 1079 antenatal women screened for thrombocytopenia and
investigated for cause and management strategies and fetomaternal outcome were recorded. Prevalence of thrombocytopenia was
8.8%. Gestational thrombocytopenia was seen in 64.2%, obstetric in 22.1% and medical in 13.68% cases. Mean platelet count
in controls was lower with a significant fall (P < 0.001) in the platelet count as pregnancy advanced. Hypertensive and hepatic disorders were the most common obstetric causes
of thrombocytopenia. Mode of delivery was not affected by thrombocytopenia. Maternal morbidity and mortality was seen only
in medical and obstetric thrombocytopenia. The low platelet counts and declining trend with increasing gestational age predispose
Indian women to risk of thrombocytopenia and a routine platelet count is suggested. 相似文献
66.
Vidushan Nadarajah Ryan Roach Abhishek Ganta Michael J. Alaia Mehul R. Shah 《The Physician and sportsmedicine》2017,45(2):165-177
Anterior cruciate ligament (ACL) injuries are among the most commonly studied orthopaedic injuries. Despite having an excellent prognosis, complications do occur. The timely recognition and management of complications is imperative to ensure the success of reconstruction. Avoiding such complications requires thorough preoperative planning, proficient technical skills to properly manage intraoperative complications, and an extensive knowledge of possible postoperative complications. 相似文献
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Abhishek Jaiswal MD Naga Vaishnavi Gadela MBBS David Baran MD Kathir Balakumaran MD Andrew Scatola MD Joseph Radojevic MD Jason Gluck MD Sabeena Arora MD Jonathan Hammond MD Ayyaz Ali MD Douglas L. Jennings PharmD William L. Baker PharmD 《Journal of the American Geriatrics Society》2021,69(9):2507-2517
68.
Neha?Singh Avinash?C.?Tripathi Aseem?Tewari Ravi?Kumar Shailendra?K.?SarafEmail author 《Medicinal chemistry research》2015,24(5):1927-1941
A series of new 5-aryliden-2-imino-4-thiazolidinones (5a–e and 6a–e) were synthesized via a three-step reaction and characterized by physicochemical and spectral data. The uniqueness of the derivatives lies in the fact that none of them had an acidic group, like conventional NSAIDS, but exhibited significant in vivo activity in acute inflammation models. In particular, 5-(3-chlorobenzyliden)-2-(pyridin-2-yl-imino)-4-thiazolidinone(5a) and 5-(3-chlorobenzyliden)-2-(5-methylisoxazol-3-yl-imino)-4-thiazolidinone (6a) showed remarkable paw oedema inhibition (67.76 and 74.47 % oedema inhibition, respectively, after 3 h) comparable to that of Ibuprofen (74.56 % oedema inhibition, after 3 h) at half of the dose of the standard drug. Also, compounds 5a (72.86 %) and 6a (80.20 %) were found to possess significant inhibition of albumin denaturation when screened for in vitro anti-inflammatory activity. In addition, these compounds were docked into the known active site of COX-2 protein using Glide XP and QPLD algorithms, and the binding-free energy was calculated using Prime MM/GBSA simulation methods. The combined use of molecular docking and MM/GBSA methods gave a good correlation between the predicted binding-free energy and experimentally determined biological activities. It was also evident from the docking results that 2-methylisoxazolylimino or 2-(pyridin-2-yl-imino substitution and 3-chloro moiety on 5-benzylidin nucleus of these 4-thiazolidinone derivatives can easily occupy the COX-2 binding pocket, considered as the critical interaction for COX-2 inhibition. Moreover, pharmacokinetic properties of all the synthesized compounds were predicted, with good results. Further, the synthesized derivatives showed neither acute toxicity nor symptoms of gastric ulceration, at extended doses, owing to the absence of an acidic group. 相似文献
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Alkesh Kumar Khurana Vikas Gupta Deepti Joshi Abhishek Goyal Ujjawal Khurana Abhijit Pakhare 《The Indian journal of tuberculosis》2021,68(2):215-220
IntroductionThe variable course of illness in patients of Tubercular lymphadenitis remains a therapeutic challenge to treating physicians in a significant proportion of patients. This study was aimed to explore the possible determinants which could predict the outcome of this subgroup of patients.MethodologyThis was a prospective cohort study where 94 patients of TB lymphadenitis were enrolled who could be followed up till the end of treatment. They were evaluated in the beginning and monitored till the end of treatment keeping into account the clinical behaviour of lymph nodes during the course of Anti tubercular chemotherapy.ResultsOut of 94 patients, 60 had their lymph nodes resolved at the end of prescribed treatment duration wheras 34 were classified as partial responders. Another 26 amongst them had their nodes resolved by an extension of continuation phase by 3–6 months. Presence of bilateral and multiple lymph nodes, necrosis on Fine needle aspiration at initial diagnosis and occurrence of Paradoxical upgrading reaction were associated with the partial resolution of lymph nodes at the end of stipulated ATT duration.ConclusionTreatment duration should be individualized by the treating physicians. Certain parameters mentioned above can be taken as warning signals of patients ending up as partial responders and hence the need of a prolonged extension phase. 相似文献