全文获取类型
收费全文 | 2547篇 |
免费 | 159篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 89篇 |
妇产科学 | 40篇 |
基础医学 | 242篇 |
口腔科学 | 112篇 |
临床医学 | 224篇 |
内科学 | 632篇 |
皮肤病学 | 29篇 |
神经病学 | 182篇 |
特种医学 | 90篇 |
外科学 | 259篇 |
综合类 | 140篇 |
一般理论 | 9篇 |
预防医学 | 202篇 |
眼科学 | 93篇 |
药学 | 214篇 |
中国医学 | 7篇 |
肿瘤学 | 155篇 |
出版年
2023年 | 40篇 |
2022年 | 159篇 |
2021年 | 186篇 |
2020年 | 97篇 |
2019年 | 117篇 |
2018年 | 145篇 |
2017年 | 82篇 |
2016年 | 73篇 |
2015年 | 90篇 |
2014年 | 119篇 |
2013年 | 129篇 |
2012年 | 202篇 |
2011年 | 160篇 |
2010年 | 105篇 |
2009年 | 91篇 |
2008年 | 111篇 |
2007年 | 116篇 |
2006年 | 97篇 |
2005年 | 106篇 |
2004年 | 89篇 |
2003年 | 91篇 |
2002年 | 79篇 |
2001年 | 23篇 |
2000年 | 20篇 |
1999年 | 16篇 |
1998年 | 22篇 |
1997年 | 8篇 |
1996年 | 8篇 |
1995年 | 9篇 |
1994年 | 3篇 |
1993年 | 9篇 |
1992年 | 13篇 |
1991年 | 10篇 |
1990年 | 12篇 |
1989年 | 8篇 |
1988年 | 12篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1976年 | 3篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1970年 | 3篇 |
排序方式: 共有2736条查询结果,搜索用时 15 毫秒
51.
52.
Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population 总被引:1,自引:0,他引:1
Abubaker J Jehan Z Bavi P Sultana M Al-Harbi S Ibrahim M Al-Nuaim A Ahmed M Amin T Al-Fehaily M Al-Sanea O Al-Dayel F Uddin S Al-Kuraya KS 《The Journal of clinical endocrinology and metabolism》2008,93(2):611-618
CONTEXT: Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been detected in numerous and diverse human cancers. PIK3CA, which encodes for the catalytic subunit of p110alpha of PI3K, is amplified in some cases of papillary thyroid cancer (PTC). Mutations in the PIK3CA have also been identified in thyroid cancers and, although relatively common in anaplastic thyroid carcinoma, are uncommon in PTC. OBJECTIVE: The objective of the study was to investigate genetic alterations like PIK3CA gene mutation, PIK3CA amplification, RAS, and RAF mutations and to further explore the relationship of these genetic alterations with various clinicopathological characteristics in Middle Eastern PTC. DESIGN: We used the fluorescence in situ hybridization technique for analysis of PIK3CA amplification from 536 PTC cases, and selected amplified samples were further validated by real-time quantitative PCR. Mutation analysis was done by direct DNA sequencing of PIK3CA, N2-RAS, and BRAF genes. RESULTS: PIK3CA amplification was seen in 265 of 499 PTC cases analyzed (53.1%); PIK3CA gene mutations in four of 207 PTC (1.9%); N2-RAS mutations in 16 of 265 PTC (6%); and BRAF mutations in 153 of 296 PTC (51.7%). N-RAS mutations were-associated with an early stage (P = 0.0465) and lower incidence of extrathyroidal extension (P = 0.027), whereas BRAF mutations were-associated with metastasis (P = 0.0274) and poor disease-free survival (P = 0.0121) in PTCs. CONCLUSION: A higher incidence of PIK3CA alterations and the possible synergistic effect of PIK3CA alterations and BRAF mutations suggest their major role in Middle Eastern PTC tumorigenesis and argue for therapeutic targeting of PI3K/AKT and MAPK pathways. 相似文献
53.
54.
Elfanagely Yousef Tse Chung Sang Tanzer Joshua Ray Monteiro Joao Filipe G. Kogan Lawrence Rich Harlan Hyder Sarah M. 《Digestive diseases and sciences》2022,67(6):2074-2080
Digestive Diseases and Sciences - New innovations and increasing utility of endoscopic ultrasound (EUS) are associated with rare but serious risks. We investigate the rates and risk factors for... 相似文献
55.
N Alrashdi Mousa Saleh Alanazi Majed Khalid Almoaqly Alshaya Abdulrahman Khaled Alanazi Sultan Mahja Marzouq 《Clinical rheumatology》2022,41(5):1577-1582
Clinical Rheumatology - Coronavirus disease-19 (COVID-19) is a global pandemic that is caused by COVID-19 virus, which was initially identified in December 2019 in Wuhan, China. Vaccination is one... 相似文献
56.
Shams-Eldin Abdulrahman N. Yafasova Adelina Faurschou Mikkel Schou Morten Sun Guoli Gislason Gunnar H. Torp-Pedersen Christian Fosbøl Emil L. Køber Lars Butt Jawad H. 《Clinical rheumatology》2022,41(11):3525-3536
Clinical Rheumatology - Autoimmune diseases, including systemic lupus erythematosus, have been associated with a substantial risk of cardiovascular morbidity and mortality. However, data on the... 相似文献
57.
58.
The effect of unit,depth, and probe load on the reliability of muscle shear wave elastography: Variables affecting reliability of SWE
下载免费PDF全文
![点击此处可从《Journal of clinical ultrasound : JCU》网站下载免费的PDF全文](/ch/ext_images/free.gif)
59.
Virk Zain M. Song Andrew B. Badran Yousef R. Al-Samkari Hanny 《Journal of thrombosis and thrombolysis》2022,54(2):255-259
Journal of Thrombosis and Thrombolysis - Heyde syndrome is characterized by the co-occurrence of aortic stenosis and bleeding gastrointestinal angiodysplasias, often with acquired von Willebrand... 相似文献
60.
Haslak Fatih Barut Kenan Durak Cansu Aliyeva Ayten Yildiz Mehmet Guliyeva Vafa Varol Sevki Erdem Cebeci Sinem Oral Aygun Fatih Varli Yusuf Ziya Ozel Abdulrahman Onan Sertac Hanedan Kocoglu Ulkem Erol Meltem Karagozlu Fatih Ulug Nujin Dedeoglu Reyhan Sahin Sezgin Adrovic Amra Oztunc Funda Kasapcopur Ozgur 《Clinical rheumatology》2021,40(10):4167-4178
Clinical Rheumatology - Multi-system inflammatory syndrome in children (MIS-C) is a less understood and a rare complication of coronavirus disease-2019 (COVID-19). Given the scarce data regarding... 相似文献