全文获取类型
收费全文 | 3613篇 |
免费 | 424篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 87篇 |
妇产科学 | 106篇 |
基础医学 | 396篇 |
口腔科学 | 234篇 |
临床医学 | 452篇 |
内科学 | 597篇 |
皮肤病学 | 76篇 |
神经病学 | 397篇 |
特种医学 | 202篇 |
外科学 | 567篇 |
综合类 | 99篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 352篇 |
眼科学 | 64篇 |
药学 | 251篇 |
中国医学 | 6篇 |
肿瘤学 | 137篇 |
出版年
2023年 | 47篇 |
2021年 | 63篇 |
2020年 | 63篇 |
2019年 | 72篇 |
2018年 | 105篇 |
2017年 | 82篇 |
2016年 | 76篇 |
2015年 | 66篇 |
2014年 | 118篇 |
2013年 | 128篇 |
2012年 | 174篇 |
2011年 | 146篇 |
2010年 | 97篇 |
2009年 | 102篇 |
2008年 | 116篇 |
2007年 | 154篇 |
2006年 | 146篇 |
2005年 | 135篇 |
2004年 | 131篇 |
2003年 | 113篇 |
2002年 | 140篇 |
2001年 | 115篇 |
2000年 | 115篇 |
1999年 | 105篇 |
1998年 | 62篇 |
1997年 | 41篇 |
1996年 | 36篇 |
1995年 | 34篇 |
1994年 | 59篇 |
1993年 | 43篇 |
1992年 | 84篇 |
1991年 | 84篇 |
1990年 | 68篇 |
1989年 | 81篇 |
1988年 | 72篇 |
1987年 | 68篇 |
1986年 | 67篇 |
1985年 | 53篇 |
1984年 | 51篇 |
1983年 | 42篇 |
1982年 | 36篇 |
1981年 | 21篇 |
1980年 | 25篇 |
1979年 | 33篇 |
1978年 | 29篇 |
1977年 | 24篇 |
1974年 | 20篇 |
1973年 | 35篇 |
1972年 | 22篇 |
1970年 | 19篇 |
排序方式: 共有4048条查询结果,搜索用时 15 毫秒
91.
92.
Kenneth S. Brandenburg MS Diego F. Calderon DVM Patricia R. Kierski BA Amanda L. Brown BS Nihar M. Shah PhD Nicholas L. Abbott PhD Michael J. Schurr MD Christopher J. Murphy DVM PhD Jonathan F. McAnulty DVM PhD Charles J. Czuprynski PhD 《Wound repair and regeneration》2015,23(6):842-854
Chronic nonhealing skin wounds often contain bacterial biofilms that prevent normal wound healing and closure and present challenges to the use of conventional wound dressings. We investigated inhibition of Pseudomonas aeruginosa biofilm formation, a common pathogen of chronic skin wounds, on a commercially available biological wound dressing. Building on prior reports, we examined whether the amino acid tryptophan would inhibit P. aeruginosa biofilm formation on the three‐dimensional surface of the biological dressing. Bacterial biomass and biofilm polysaccharides were quantified using crystal violet staining or an enzyme linked lectin, respectively. Bacterial cells and biofilm matrix adherent to the wound dressing were visualized through scanning electron microscopy. d ‐/l ‐tryptophan inhibited P. aeruginosa biofilm formation on the wound dressing in a dose dependent manner and was not directly cytotoxic to immortalized human keratinocytes although there was some reduction in cellular metabolism or enzymatic activity. More importantly, d ‐/l ‐tryptophan did not impair wound healing in a splinted skin wound murine model. Furthermore, wound closure was improved when d ‐/l ‐tryptophan treated wound dressing with P. aeruginosa biofilms were compared with untreated dressings. These findings indicate that tryptophan may prove useful for integration into wound dressings to inhibit biofilm formation and promote wound healing. 相似文献
93.
Solid Organ Transplantation From Hepatitis B Virus–Positive Donors: Consensus Guidelines for Recipient Management
下载免费PDF全文
![点击此处可从《American journal of transplantation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
S. Huprikar L. Danziger‐Isakov J. Ahn S. Naugler E. Blumberg R. K. Avery C. Koval E. D. Lease A. Pillai K. E. Doucette J. Levitsky M. I. Morris K. Lu J. K. McDermott T. Mone J. P. Orlowski D. M. Dadhania K. Abbott S. Horslen B. L. Laskin A. Mougdil V. L. Venkat K. Korenblat V. Kumar P. Grossi R. D. Bloom K. Brown C. N. Kotton D. Kumar 《American journal of transplantation》2015,15(5):1162-1172
Use of organs from donors testing positive for hepatitis B virus (HBV) may safely expand the donor pool. The American Society of Transplantation convened a multidisciplinary expert panel that reviewed the existing literature and developed consensus recommendations for recipient management following the use of organs from HBV positive donors. Transmission risk is highest with liver donors and significantly lower with non‐liver (kidney and thoracic) donors. Antiviral prophylaxis significantly reduces the rate of transmission to liver recipients from isolated HBV core antibody positive (anti‐HBc+) donors. Organs from anti‐HBc+ donors should be considered for all adult transplant candidates after an individualized assessment of the risks and benefits and appropriate patient consent. Indefinite antiviral prophylaxis is recommended in liver recipients with no immunity or vaccine immunity but not in liver recipients with natural immunity. Antiviral prophylaxis may be considered for up to 1 year in susceptible non‐liver recipients but is not recommended in immune non‐liver recipients. Although no longer the treatment of choice in patients with chronic HBV, lamivudine remains the most cost‐effective choice for prophylaxis in this setting. Hepatitis B immunoglobulin is not recommended. 相似文献
94.
95.
David Phong Nguyen Britt Klein Denny Meyer David William Austin Jo-Anne M Abbott 《Journal of medical Internet research》2015,17(9)
Background
Internet-based assessment has the potential to assist with the diagnosis of mental health disorders and overcome the barriers associated with traditional services (eg, cost, stigma, distance). Further to existing online screening programs available, there is an opportunity to deliver more comprehensive and accurate diagnostic tools to supplement the assessment and treatment of mental health disorders.Objective
The aim was to evaluate the diagnostic criterion validity and test-retest reliability of the electronic Psychological Assessment System (e-PASS), an online, self-report, multidisorder, clinical assessment and referral system.Methods
Participants were 616 adults residing in Australia, recruited online, and representing prospective e-PASS users. Following e-PASS completion, 158 participants underwent a telephone-administered structured clinical interview and 39 participants repeated the e-PASS within 25 days of initial completion.Results
With structured clinical interview results serving as the gold standard, diagnostic agreement with the e-PASS varied considerably from fair (eg, generalized anxiety disorder: κ=.37) to strong (eg, panic disorder: κ=.62). Although the e-PASS’ sensitivity also varied (0.43-0.86) the specificity was generally high (0.68-1.00). The e-PASS sensitivity generally improved when reducing the e-PASS threshold to a subclinical result. Test-retest reliability ranged from moderate (eg, specific phobia: κ=.54) to substantial (eg, bulimia nervosa: κ=.87).Conclusions
The e-PASS produces reliable diagnostic results and performs generally well in excluding mental disorders, although at the expense of sensitivity. For screening purposes, the e-PASS subclinical result generally appears better than a clinical result as a diagnostic indicator. Further development and evaluation is needed to support the use of online diagnostic assessment programs for mental disorders.Trial Registration
Australian and New Zealand Clinical Trials Registry ACTRN121611000704998; http://www.anzctr.org.au/trial_view.aspx?ID=336143 (Archived by WebCite at http://www.webcitation.org/618r3wvOG). 相似文献96.
97.
98.
99.
SS Abbott TM Harrison AK Schmitt SJ Mojzsis 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(34):13486-13492
Few terrestrial localities preserve more than a trace lithic record prior to ca. 3.8 Ga greatly limiting our understanding of the first 700 Ma of Earth history, a period inferred to have included a spike in the bolide flux to the inner solar system at ca. 3.85–3.95 Ga (the Late Heavy Bombardment, LHB). An accessible record of this era may be found in Hadean detrital zircons from the Jack Hills, Western Australia, in the form of μm-scale epitaxial overgrowths. By comparing crystallization temperatures of pre-3.8 Ga zircon overgrowths to the archive of zircon temperature spectra, it should, in principle, be possible to identify a distinctive impact signature. We have developed Ti-U-Th-Pb ion microprobe depth profiling to obtain age and temperature information within these zircon overgrowths and undertaken a feasibility study of its possible use in identifying impact events. Of eight grains profiled in this fashion, four have overgrowths of LHB-era age. Age vs. temperature profiles reveal a period between ca. 3.85–3.95 Ga (i.e., LHB era) characterized by significantly higher temperatures (approximately 840–875 °C) than do older or younger zircons or zircon domains (approximately 630–750 °C). However, temperatures approaching 900 °C can result in Pb isotopic exchange rendering interpretation of these profiles nonunique. Coupled age-temperature depth profiling shows promise in this role, and the preliminary data we report could represent the first terrestrial evidence for impact-related heating during the LHB. 相似文献
100.
Christopher I. Udoye
BSc BChD FMCDS Hamid Jafarzadeh
DDS MSc Paul V. Abbott
BDSc MDS FRACDS 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2012,38(3):129-136
Management protocols for avulsed teeth should include management of the pulp and periodontal ligament (PDL) cells in order to improve the long‐term prognosis and survival of these teeth. The use of an inappropriate transport or storage medium potentially increases the risk of PDL cell necrosis, which can result in ankylosis and replacement resorption of the tooth root. Considering the critical role of these media, an informed choice of a suitable medium is essential for a favourable outcome. The literature regarding transport media for avulsed teeth was reviewed using PubMed/MEDLINE up to February 2010. This review outlines the common storage media that are available and highlights their specific features or problems. Although HBSS, ViaSpan and Eagle's medium have great potential to maintain the PDL cells in a viable state after avulsion, the practicalities of using these solutions, the costs and the lack of ready availability to the general public make them less than ideal. Milk remains the most convenient, cheapest and readily available solution in most situations while also being capable of keeping PDL cells alive. Hence, milk remains the storage medium of choice for avulsed teeth that cannot be replanted immediately or very soon after the avulsion. 相似文献