Studies on Ectopic ACTH-Producing Tumors: III. An Ectopic Melanocyte-Stimulating Hormone: Gel Chromatographic Finding and Time-Lapse Color Change of Frog Skin

On isolation of the main melanocyte-stimulating factor fromthe metastatic liver tumor of islet cell carcinoma of the pancreas,it was found to be a peptide resembling human ß-MSHin the time-lapse skin darkening response of Xenopus frogs,but different in the volume of elution on Sephadex gel chromatography.     

Inhibitory Effect of Laser Irradiation on Dermal Syngeneic Tumor Growth in Mice

Mice (C57BL/6) with established intradermal tumors (melanomaB-16 or glioma 203G1) and inbred Swiss mice (SWM/Ms) with establishedintradermal tumors (3-methylcholanthrene-induced sarcoma) weretreated by either surgical excision or laser irradiation. Laserirradiation is effective in preventing the growth of dermalmelanoma, and laser therapy may be more efficacious than surgicaltherapy for induction of a reaction against melanoma in mice. The results also suggest that determination of a suitable laserwavelength may be required to obtain a good therapeutic effecton each tumor.