衡水地区宫颈病变筛查人群HPV感染基因型、阴道清洁度与宫颈病变程度的关系

目的 探讨衡水地区宫颈病变筛查人群人乳头瘤病毒（HPV）感染基因型、阴道清洁度与宫颈病变程度的相关性。方法 选择衡水地区宫颈病变筛查人群500例,采用PCR-反向点杂交法对宫颈HPV感染情况进行检测,通过基因芯片分型法确定HPV阳性感染基因型;HPV阳性感染者采用液基薄层细胞学方法检查宫颈细胞并进行TBS分级,无上皮内病变和恶性病变（NILM）记为宫颈正常,非典型鳞状细胞（ASCUS）、低级别鳞状上皮内病变（LSIL）、高级别鳞状上皮内病变（HSIL）、鳞状细胞癌（SCC）记为宫颈病变。通过Nugent评分法评估筛查人群阴道清洁度。结果 500例宫颈病变筛查人群中,HPV阳性47例,HPV阳性感染率为9.40%。47例HPV阳性者中,高危基因型前4位分别为HPV52、HPV58、HPV16、HPV18,感染率分别为21.28%、12.77%、10.64%、8.51%。低危基因型为HPV6、HPV11,感染率分别为6.38%、4.26%。500例接受宫颈筛查人群中,发现高危HPV基因型感染42例,其中宫颈细胞TBS分级NILM 19例、ASCUS 7例、LSIL 9例、HSIL 5例、S...     

超声造影评估门静脉通畅性的适应证探讨

目的 评估常规超声和超声造影(CEUS)在门静脉通畅性诊断中的实用性及CEUS适应证.方法 比较不同声窗条件下常规超声和CEUS对64例门静脉通畅性的诊断水平.根据常规超声门静脉观测声窗条件的好坏分为3级:1级,声窗条件好;2级,声窗条件欠佳;3级,声窗条件差.结果 64例中证实门静脉栓塞35例,门静脉通畅29例.在诊断门静脉通畅性方面,常规超声和CEUS总体诊断准确性分别为76.6%和92.2%.声窗条件好时,常规超声和CEUS的诊断准确性相当,分别为93.1%、96.6%;声窗条件欠佳时,CEUS的诊断准确性较常规超声提高31.2%(87.5%对56.3%);声窗条件差时,CEUS的诊断准确性较常规超声提高21.1%(89.5%对68.4%).结论 在声窗条件好、门静脉显示清晰的条件下,常规超声诊断门静脉血流通畅性的准确程度与CEUS相当,并不一定需要行造影检查.若不具备上述条件,CEUS是值得推荐的.     

Prolift全盆底重建术与改良盆底重建术治疗女性盆底功能障碍性疾病的临床研究

目的比较Prolift全盆底重建补片和Gynemesh聚丙烯补片在全盆底重建术中的应用效果,探讨更为适宜的全盆底重建手术方式。方法将96例因盆腔脏器脱垂行盆底重建术患者随机分为2组:A组50例采用Prolift全盆底重建系统行全盆底重建术,B组46例采用Gynemesh聚丙烯补片行全盆底重建术,比较2组患者围手术期和随访情况。结果 2组患者术中出血量,术后体温、保留尿管时间、术后残余尿及住院时间比较均无显著性差异。手术所用时间A组显著短于B组(P<0.05)。术后2组C点较术前均明显提高(P<0.05)。术后2组阴道长度比较无显著性差异(P>0.05)。术后A组随访率98%,1例(2%)患者阴道前壁复发Ⅱ期,1例(2%)患者出现阴道后壁补片侵蚀,1例(2%)患者术后存在不同程度的性交痛。B组随访率96%,4例(9%)患者复发,其中阴道前壁复发Ⅱ期2例,阴道穹隆脱垂复发Ⅱ期1例;阴道后壁复发Ⅱ期1例。3例(7%)患者出现阴道补片侵蚀,3例(7%)患者阴道后壁切口周围瘢痕较僵硬,4例(9%)患者存在不同程度的性交痛。结论 Prolift和Gynemesh补片均可用于全盆底重建,手术均安全可行。在近期疗效和并发症方面,对于切除子宫的全盆底重建术,Prolift要优于Gynemesh。     

Fracture resistance and failure patterns of open apex root teeth with different posts after endodontic treatment

The aim of this study is to investigate the influence of different posts on the fracture mechanics of endodontically-treated teeth with open apex. Forty-eight human maxillary anterior teeth were collected, and the root was transversely sectioned 12 mm under the cementoenamal junction (CEJ). These samples were then randomly divided into two groups, i.e., minor diameter open apex root (group A) and major diameter open apex root (group B), with mineral trioxide aggregate (MTA) placed into the apical 4 mm in the root canals. Subsequently, both groups were respectively further divided into three subgroups as follows: fiber-post (subgroup 1), metal post (subgroup 2) and non-post (subgroup 3) group. Teeth were restored with a composite resin crown and tested by using a universal testing machine at the rate of 1 mm/min cross-head. Values of the maximum fracture resistance and failure patterns were recorded and compared among all subgroups. In addition, the changes of MTA properties were carefully examined via X-ray photography. Our results indicate that (1) In group A, the mean value of fracture resistance for teeth restored with fiber posts were statistically higher than that with either metal post or non-post; (2) In group B, there was no statistically significant difference in the mean value of fracture resistance among three subgroups; (3) No statistical significance in the mean value of fracture resistance was found between group A and group B; (4) The failure modes of most samples (58%) were irreparable; (5) MTA in two teeth developed cracks after loading tests. In conclusion, endodontically-treated teeth restored with fiber posts are more resistant to fracture than those restored with either metal posts or non-post, and most of the fracture modes are catastrophic in nature.     

超声引导下冷循环射频治疗肝癌的疗效观察

目的 评价超声引导下冷循环射频系统治疗肝癌的疗效及并发症。方法 在超声引导下经皮经肝穿刺射频或术中射频治疗肝癌患者40例，共48个病灶，对比治疗前后的影像检查，评价肝癌消融是否完全，并记录射频治疗后的并发症及其转归情况。结果 冷循环射频治疗后，当肝癌直径〈3cm，直径3-5cm，直径〉5cm时，一次治疗完全坏死率分别为95.8%,78.4%及40%，三组治疗后一年时复发率分别为0.16,40%，主要并发症是疼痛，发热，出血等。结论 冷循环电极射频治疗肝癌，是一种适应证较广泛，疗效较为确切，副作用较少的良好方法。