血钾代谢紊乱与周期性麻痹

周期性麻痹是以四肢肌肉的无力和软瘫为主要症状,反复发作,且发作的时间具有阶段性,所以称为周期性麻痹。发病缘于血清钾离子代谢失调,特别是低血钾时容易引起。该病有一定的家族遗传史,发病人群多见于青年或中年男性,或从儿童时期就开始发病。血清钾离子代谢紊乱是导致发病的主要原因,其诱因可能与感染、剧烈运动、某些药物的使用     

夏季谨防细菌性食物中毒

<正>细菌性食物中毒指的是进食了含有细菌及其毒素的食物而引发的疾病。引起食物中毒的细菌或毒素可直接存在于食物中,也可能通过餐饮人员的手或装有食品的容器间接造成食品污染,当人们食用了这些被污染的食物后就会引起中毒。临床上细菌性食物中毒以胃肠炎型最多见,但有的食物中毒还会出现胃肠道以外的其他症状,如皮肤过敏或休克。夏日,各     

感染引发的多发性神经炎

<正>急性感染性多发性神经炎又称格林-巴利综合征,是病毒感染导致的神经系统疾病。由于肢体两侧同时发病,所以又称急性对称性多发性神经根炎。该病任何年龄任何季节均可发病,男性多于女性。导致多发性神经炎的诱因与病毒感染和自身免疫功能异常有关,患者在多发性神经炎发病之前,曾有病毒感染性疾病,如感冒、带状疱疹、肝炎、支原体肺炎,或消化道的病毒感染     

解析尿毒症

<正>位于人体腹膜后脊柱两旁的肾脏,是肌体排泄系统的重要器官。尽管每侧肾脏的重量不超过150 g,但却承担着人体数十公斤体重的新陈代谢。肾功能之所以强大和重要,是因为每侧肾脏拥有100多万个由肾小球、肾球囊和肾小管组成的肾单位。肾单位是肾脏最基本的解剖和功能单位,肾小球的滤过功能和肾小管的重吸收功能,对人体的新陈代谢起着至关重要的作用。人体的血流时刻都要经过肾脏过滤和廓清,肾脏就像血液中的筛子,将代谢的废     

七氟烷用于癫痫手术麻醉及其对脑电图的影响

Objective To assess the effects of concentration of sevoflurane on the electrocorticogram (ECoG) of intractable epileptic patients or non-epileptic patients undergoing surgery and investigate the suitable concentration of sevoflurane for epilepsy surgery. Methods Of 24 patients with intractable epilepsy and 15 patients with non-epilepsy but brain diseases, ECoG were recorded under sevoflurane anesthesia with 0.7 minimum alveolar anesthetic concentration (MAC), 1.0 MAC, 1.3 MAC, and 1.5 MAC, respectively, under similar ventilatory conditions. Spike activity and other frequency brain waves were evaluated. Results The frequencies and leads of spike waves (or spike-form waves) were similar with 0.7-1.3 MAC sevoflurane anesthesia in epileptic patients, whereas the spike waves were significantly increased at 1.5 MAC in epileptic patients and 5 of 15 non-epileptic patients (P<0.05). The change of other frequencies brain waves was similar in both group: the frequency of α and β waves decreased, δ waves increased and θ waves changed a little. Conclusion The maintenance of anesthesia with 0.7-1.3 MAC sevoflurane is safe and suitable for the craniotomy surgery of epileptic patients with ECoG monitoring. Careful attention should be paid to the higher concentration of sevoflurane (>1.5 MAC) used when intraperative ECoG is used in both epileptic patients and non-epilepsy patients.     

Engelmann病1例报告

患者，女性，13岁。平时双下肢酸痛，但能忍受。2003年6月13日上体育课，跟别的同学玩耍时不甚摔倒右大腿着地，当即右大腿剧痛，不能站立，送往当地医院拍片检查发现，右股骨上1／3骨折，后转到本院骨科住院治疗。入院查体：病儿消瘦，发育欠佳，痛苦面容，被动体位。四肢长，躯干短，腿部肌肉明显消瘦，四肢长骨肿胀，可触及骨干增     

新型脊柱内固定装置治疗胸腰段爆裂性骨折

1998年初始．针对目前脊柱椎弓根内周定器械结构复杂，操作繁锁的缺点，研制出一种结构简单，操作方便，固定牢固的内固定器械，经12例的临床应用疗效满意，现报告如下：     

夏秋季 防菌痢

说到菌痢，大家都知道这是夏秋季节常见的传染病之一。天热了，又到了菌痢肆虐时，提醒大家要以预防为主。     

鞘内注射97-9-G4 PLGA缓释微球对神经病理陛疼痛大鼠痛行为的影响

Objective To study the pain killing effects of intratheeal injection of 97-9-G4 PLGA sustained-release microspheres in the SD rat model of CCI of sciatic nerve. Methods SD rats with intrathecal catheter deployment were randomly divided into 4 groups(n=8): normal saline group(NS group), 97-9-G4 group (G group), 97-9-G4 PLGA sustained-release microspheres group(SRG group) and blank PLGA group(P group). On the 11th day after CCI, the animals in NS group and G group were administered the relevant drugs three times (7 am, 1 pm and 7 pm; i.t.). Those in SRG group and P group were administered only once (7 am; i.t.). Paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured 5 times at the fixed time-point within the period of study. Results The drug entrapment efficiency was 80.4%, drug loading efficiency was 27.78%, and the mean diameter of microspheres was 77 μm. Two peaks of 97-9-G4 were observed in vitro release measurement. About 25.28% was released in the first 30 rain and about 71.33% was accumulated released in the period from 30 rain to 24 hours. Till 10 days, about 98.3% of 97-9-G4 was accumulated released from the microspheres. In vivo, compared with basic pain threshold, all groups, except sham group exhibited similar values of PWMT and PWTL at the beginning of drug administration. After drug administration, compared with NS group, the values of PWMT and PWTL were significantly increased at 8 am, 2 pm and 8 pro(P＜0.05). At 12 am and 6 pm, there was no significant difference (P＞0.05). Compared with NS group, the values of PWMT and PWTL in group SRG were significantly increased at all the time points except at 8 am. No significant difference was demonstrated in the values of group P as compared with group NS (P＞0.05). Conclusion 97-9-G4 PLGA sustained-release microspheres demonstrate good appearance and significant in vitro sustained-release characteristics. In rat CCI models, the microspheres demonstrate good sustained-release effect and efficiently raised the PWMT and PWTL. The sustained-release effect could last more than 12 hours in vivo.     

折断式加压螺钉治疗股骨粗隆间骨折

我院自2004年5月开始用折断式加压螺钉治疗股骨粗隆间骨折，使操作更为简化，并取得了较好的疗效。现报告如下：