80例先天性心脏病DSA、灰阶B超诊断与手术结果对比分析

报告80例先心病DSA、B超与手术对照结果:DSA及B超诊断符合者分别为75例(93.75％)与63例(78.75％).提示DSA诊断准确率高于B超;若二者结合,诊断符合者为79例,符合率98.75％。文中还讨论了DSA、 B超对常见先心病的诊断特征以及诊断限度.     

The therapeutic effects of modified Cox-Maze Ⅲ procedure using bipolar radiofrequency ablation for rheumatic valve disease combined with permanent atrial fibrillation

Objective The present study was designed to evaluates the short term effect of modified Cox-Maze Ⅲ procedure using bipolar radiofrequency ablation (BPRF) on the combination of rheumatic valve disease and long-standing permanent atrial fibrillation(AF). Methods Thirteen cases of rheumatic valve dis-ease with permanent AF received BPRF modified Cox-Maze Ⅲ procedure using the Medtronic Cardioblate BP system from May 2007 to May 2008. The therapeutic effect was evaluated. Results The average age of the pa-tients were 56.5 (range 44-65) years,average duration of AF were 5 (2-11) years and the average left atrial diameter was (55.1±5.9) mm. No mortalities or severe complications were seen in all the 13 patients during the study period. The average time for cross clamping of the aorta was 10 min. The AF was disappeared in all 13 patients immediately after the procedure. Successful restoration of sinus rhythm has been achieved in 12 pa-tients (92.3%) during the follow-up of 6-17 (9.2±3.2) months,while one patient had recurrence of AF. Conclusion The Cox-Maze Ⅲ procedure with BPRF using the Medtronic Cardioblate BP system is a safe and effective treatment for patients suffering from rheumatic valve disease combined with permanent AF. ±3.2     

The therapeutic effects of modified Cox-Maze Ⅲ procedure using bipolar radiofrequency ablation for rheumatic valve disease combined with permanent atrial fibrillation

Objective The present study was designed to evaluates the short term effect of modified Cox-Maze Ⅲ procedure using bipolar radiofrequency ablation (BPRF) on the combination of rheumatic valve disease and long-standing permanent atrial fibrillation(AF). Methods Thirteen cases of rheumatic valve dis-ease with permanent AF received BPRF modified Cox-Maze Ⅲ procedure using the Medtronic Cardioblate BP system from May 2007 to May 2008. The therapeutic effect was evaluated. Results The average age of the pa-tients were 56.5 (range 44-65) years,average duration of AF were 5 (2-11) years and the average left atrial diameter was (55.1±5.9) mm. No mortalities or severe complications were seen in all the 13 patients during the study period. The average time for cross clamping of the aorta was 10 min. The AF was disappeared in all 13 patients immediately after the procedure. Successful restoration of sinus rhythm has been achieved in 12 pa-tients (92.3%) during the follow-up of 6-17 (9.2±3.2) months,while one patient had recurrence of AF. Conclusion The Cox-Maze Ⅲ procedure with BPRF using the Medtronic Cardioblate BP system is a safe and effective treatment for patients suffering from rheumatic valve disease combined with permanent AF. ±3.2     

小肝癌划分阈值的临床研究北大核心CSCD

目的 探讨划分小肝癌大小定义的阈值选择.方法 选择2003年12月至2013年7月在中国医学科学院北京协和医学院肿瘤医院接受手术的222例小肝癌患者临床,病理资料与随访,根据肝癌大小分为＜2 cm组、2～3 cm组与＞3～5 cm组.应用Kaplan-Meier法进行生存分析,组间应用log-rank法进行比较,采用COX风险比例模型进行多因素分析.结果 本组患者1、3、5及10年生存率分别为：95.9％、85.3％、67.8％及53.3％.肿瘤≤3 cm组1、3及5年生存率分别为：98.3％、90.1％及72.1％,肿瘤＞3 ～5 cm组1、3及5年生存率分别为：93.1％、79.9％及62.8％,组间差异有统计学意义（x2=6.034,P=0.014）.多因素分析结果显示：甲胎蛋白,肝癌分化程度,肝硬化,肿瘤被膜及肝癌直径（≤3 cm组与＞3 ～5 cm组）为肝癌患者的独立预后因素.结论 本研究认为,在以2、3、5 cm为小肝癌的阈值划分中,以3 cm更具临床指导意义.该阈值与患者预后情况密切相关,同时可作为患者长期生存独立预测因素.     

超声引导下甲状腺射频消融临床研究进展

甲状腺结节是临床上常见的疾病,并且大多数结节为良性。甲状腺良性结节经射频消融(radiofrequency ablation,RFA)治疗后,体积能明显缩小,甚至消失。从而改善结节引起的相关症状。近年来RFA已逐渐成为甲状腺良性结节的首选治疗方法。本文是对近些年来甲状腺射频消融临床研究进展进行综述,从而为临床甲状腺射频消融治疗提供指导和依据。     

西昌市农村留守学生青春期健康教育现状的调查结果与对策分析

目的：了解西昌市农村留守学生掌握青春期生理知识的情况及其心理状态,探索为农村留守学生进行青春期健康教育的最佳方法。方法：采用随机分层整群抽样法对西昌市农村地区4所初级中学、3所小学的农村留守学生进行一对一的问卷调查。结果：调查结果显示,西昌市农村留守学生在青春期健康知识及性生理知识的掌握度、青春期心理、性心理方面存在诸多问题、盲点和误区。结论：西昌市农村留守学生接受的青春期健康教育有所缺失,其在青春期心理、行为等方面存在严重的问题。有关部门必须充分重视西昌市农村留守学生的青春期健康教育工作,加强对其进行青春期健康教育的力度。     

大剂量细胞色素C抢救急性磷化铝中毒72例

<正> 一般情况 1985～1994年近10年间,据不完全统计我院共收治口服磷化铝急性中毒患者79例,其中男14例,女65例,男女比例1∶6,最大年龄68岁,最小16岁,平均29.4岁,服药剂量为1～3片(该药分别为河南郑洲炼油厂、山东济宁化工实验厂生产,每片3.2g,含磷化铝65％)服药后距就诊时间为30min至8h,79例均无院前治疗史。     

原发性肝癌患者血小板活化与血管内皮损伤标志物检测及临床意义

目的：探讨原发性肝癌患者血小板活化指标CD62P、CD63与血管内皮损伤指标vWF、vWF—cp的变化及其临床意义。方法：采用流式细胞术、免疫比浊法和免疫印记-发光绘图法（SWL法）分别检测34例原发性肝癌患者和50例健康成人的CD62P、CD63、vWF和vWF-cp水平。结果：原发性肝癌患者CD62P、CD63和vWF水平高于健康成人（P〈0．01）,vWF—cp活性低于健康成人（P〈0．01）,差异均有统计学意义。结论：原发性肝癌患者体内存在血小板活化和血管内皮损伤,CD62P、CD63和vwF水平升高,vWF-cp活性降低,可能共同参与了疾病的发生发展。     

点灸为主结合用药治疗小儿手足口病临床疗效分析

目的：探讨点灸法治疗小儿手足口病的疗效,观察点灸对皮疹、口腔疱疹消退,便秘或便溏消退,消化不良和厌食等症状的疗阍。方法：46例患儿分为2组,分别采用点灸结合常规西药疗法（灸药组22例）、常规西医疗法（西药组24例）,2组治疗7d后分别采用疗效指数综合判定疗效,比较2组疗效差异。结果：灸药组疗效优于西药组,显效率比较有显著性差异（P〈0．05）。2组间在皮疹、口腔疱疹,便秘或便溏,消化不良和厌食消退时间上比较,差异均有显著性（P〈0．05）,灸药组优于西药组。结论：点灸结合常规西药疗法治疗小儿手足口病疗效明显,可有效地改善消化道等症状,缩短病程,减少患者痛苦。     

白皮杉醇抗恶性黑色素瘤的体内外实验研究

目的 研究白皮杉醇(PIC)的体内外抗恶性黑色素瘤作用.方法 体外培养来源于小鼠皮肤的恶性黑色素瘤细胞系B16F10,以梯度浓度PIC处理细胞后甲基噻唑基四唑(MTT)法检测细胞活力;蛋白印迹法检测金属基质蛋白酶(MMP)-2及MMP-9、血管内皮生长因子(VEGF)、脾酪氨酸激酶(Syk)及p-Syk的表达;划痕实验...