N14对正常大鼠消化道致溃疡作用

目的 观察N14是否有致胃肠溃崭作用。方法 对正常大鼠进行连续ig给药7 d．1次·d^-t并与阿斯匹林、吲哚美辛进行对照．剂量分别为N14，25，50，100mg·kg^-1，阿斯匹林25，50．100mg·kg^-1，吲哚美辛1．25，2．5,5mg·kg^-1．结果 N14组与溶媒对照组的结果相近．各大鼠均无明显胃肠溃疡发生，阿斯匹林有明显致胃溃痔作用(P<0．05)，吲哚美辛有非常明显的致胃溃汤作用(P<0.01)．结论N14对胃肠遭无致溃汤作用，为进一步研究该药提供实验数据．     

护理干预对肝癌介入治疗患者的依从性和胃肠道反应的影响

目的：探讨护理干预对肝癌介入治疗患者的依从性和胃肠道反应的影响.方法：将140例肝癌介入治疗的患者随机分为观察组和对照组各70例,对照组采用常规基本护理,观察组给予系统的健康教育和心理饮食护理.观察并比较2组患者肝癌介入依从性和胃肠道反应发生情况.结果：观察组患者的介入依从性评分高于对照组,胃肠道反应评分低于对照组（P〈0.01）.结论：术前采用系统的健康教育和术后给予正确的饮食、心理护理,可增加肝癌介入治疗的患者依从性,同时减少了胃肠道反应的发生.     

苡仁双防散治疗高尿酸血症临床研究

目的：观察苡仁双防散治疗高尿酸血症的临床疗效。方法：将216例患者随机分为2组。治疗组（苡仁双防散）144例,对照组（别嘌呤醇）72例,观察治疗后临床疗效。结果：治疗组总有效率96.5%,对照组总有效率84.7%,2组比较差异有统计学意义（P〈0.01）;治疗组治疗期间无明显不良反应。结论：该药治疗高尿酸血症疗效确切,且无明显副反应。     

自我报告结局手册在肿瘤患者免疫治疗居家期症状管理中的应用

目的 探索肿瘤患者免疫治疗居家期症状管理的有效方法。方法 将132例肿瘤免疫治疗患者随机分为对照组和干预组各66例。对照组给予常规健康教育和护理,干预组在对照组的基础上使用自制自我报告结局手册。干预6个月后,比较两组免疫治疗相关不良反应报告准确率、报告时间、严重程度、症状负担和生存质量。结果 对照组与干预组分别有62例、63例完成全程研究。干预组免疫治疗相关不良反应报告准确率显著高于对照组,报告时间显著短于对照组,症状负担轻于对照组,生存质量高于对照组(均P<0.05)。结论 自我报告结局手册可帮助患者辨别免疫治疗相关不良反应,提高报告准确性和缩短报告时间,减轻患者的症状负担,提高生活质量。     

经尿道前列腺电切术联合内分泌去势疗法治疗晚期前列腺癌的临床疗效

目的 研究经尿道前列腺电切术联合内分泌去势疗法治疗晚期前列腺癌的临床效果。方法 从2017年1月11日至2019年1月11日,收集郑州大学第二附属医院收入治疗的晚期前列腺癌患者中,选取114例作为此次研究对象,根据治疗方式不同分为对照组和观察组,将内分泌去势疗法患者设为对照组(57例),将经尿道前列腺电切术联合内分泌去势疗法设为观察组(57例),观察对比两组患者生活质量、实验室各项指标、治疗总有效率和三年的生存率。结果 治疗前,两组生活质量相比差异无统计学意义(P>0.05),治疗后,两组生活质量均有改善,且对比提示观察组优于对照组,P<0.05。治疗前,两组实验室各项指标相比差异无统计学意义(P>0.05),治疗后,观察组前列腺特异性抗原(PSA)和血管内皮生长因子(VEGF)的水平较对照组低,最大的尿流率较对照组高,残余尿量较对照组少,P<0.05。观察组治疗总有效率为96.49%,与对照组的84.21%相比明显增高,对比差异有统计学意义(P<0.05)。观察组1年生存率100.00%,两年生存率91.23%,三年生存率77.19%,均较对照组的87....     

针灸择期治疗周围性面瘫多中心大样本随机对照试验

目的:探讨针灸治疗周围性面瘫(贝尔面瘫)的最佳介入时机和针灸择期治疗本病的临床优势方案.方法:采用多中心大样本随机对照试验方法,将900例贝尔面瘫患者随机分为分期针刺、分期针刺加灸、分期针刺加电针、分期针刺加经筋排刺以及不分期针刺5个治疗组,分别接受4个疗程的治疗,并在入组、治疗4个疗程后以及治疗后1月、3月随访中分别...     

《中药药剂学》说课设计

通过课程设置、教学内容、教学对象及数学方法等多方面对《中药药剂学》课程进行说课设计,以提高教师的教学能力。     

人角膜内皮细胞压力调节培养的初步研究

Objective To investigate the effect of pressure bionic culture on the morphology and function of rabbit corneal endothelial cells. Methods Corneal endothelial cells were separated and purified by tearing apart the descemet and digesting with trypsin and EDTA, then cultured in the plate. The cells were divided into two groups: group A were cultured under atmosphere; cells exposed to 2 kPa( 14. 66 mm Hg) pressure in vitro was group B; the morphology and growth pattern of cells were observed by inverted microscope; cells origin were identified by neuron-specific enolase immunoassay. Cellular changes in the structure were observed by HE staining and scanning and transmission electron microscopy (SEM and TEM) analysis. Cells activity was detected by flow cytometry. Results NSE antibody of the primary corneal endothelial cells was positive without corneal epithelial cells and corneal stroma cells. Two groups of cells were cultured for 120-144 h respectively, the morphology was flat, polygon, most of cells were hexagon and abundant cytoplasms in group B (pressure bionic culture), but in group A, the cells size was not uniform and there were much granules in the cytoplasm. There was no difference in the time of formation of monolayer in two groups. SEM showed that cells exposed to pressure connected tightly and the surface was rich in microvilli, extended foot processes and attached to the substrate tightly, while cells cultured under atmosphere with more off-chip. In group B, Annexiv-FITC/PI detection of apoptosis showed cell survival rate was 98.2%, early apoptosis rate was 0.7%, late apoptosis rate was 1.0%, death rate was 0. 1%; the corresponding data were 92.2%, 5.2%, 2.3%, and 0.3% in group A, respectively; There was statistically significant difference between the two groups (x2 =594. 0,P ＜0. 01 ). After cultured for 96 h,the expression of ZO-1 protein in cells exposed to pressure was higher than those in control. Conclusions The biological activity of endothelial cells is regulated positively by bionic pressure. The establishment of a new biomimetic pressure model will help to investigate the physiological function and injury repair of corneal endothelial cells in vitro.     

橄榄体脑桥小脑萎缩1例

1 病例报告 患者女,51岁。步态不稳、歪斜11年余。患者于11年前无明显诱因出现步态不稳,症状轻微,独立行走无歪斜,偶伴头晕。此后逐渐出现行动缓慢、不能直线行走、频繁摔倒、双眼睑不自主颤动、言语不清、吞咽困难、饮水呛咳、视物模糊、近事遗忘、记忆力明显减退,生活不能自理。查体：面部表情呆板,     

急性髓细胞性白血病M2a型皮肤浸润一例北大核心CSCD

患者女,47岁,因面部、四肢皮肤红斑2个月伴间歇发热20余天就诊。患者2个月前出现面颊、颈部红斑,形状不规则,略高于表面,感疼痛不适,不久患者唇部出现散在水疱,伴疼痛,颊部斑块渗出、结痂,颜色渐转暗,边缘呈环状隆起,伴颜面水肿,四肢也逐渐出现红色斑块,20余天前出现发热,体温最高达39℃,无畏寒、寒战．无咳嗽咳痰,无胸闷气急。外院查血常规：血红蛋白96g／t,白细胞5．29×10°L。