浅谈周岱翰教授从脾胃学说论治肿瘤的临床经验

总结周岱翰教授运用脾胃学说论治肿瘤的临床经验。周教授认为：1）治疗晚期肿瘤,论治不忘补中,健脾不忘通腑。2）重视饮食调理,药治食疗并重。3）遣方用药,贵在灵活。周教授把脾胃学说理论应用到恶性肿瘤的辨治上,是对脾胃学说的进一步发展与补充,体现了＂师古而不泥古＂的精神。     

中医辨证治疗乳腺癌抑郁症30例临床观察

目的:在对乳腺癌抑郁症进行辨证分型的基础上,根据不同的证候特点予以逍遥散加减辨证治疗,评估逍遥散为主辨证加减对乳腺癌抑郁症的治疗效果.方法:采用单纯随机分组方法(信封法),将合格病例60例按1∶1的比例随机分配入治疗组和对照组,按分型标准辨证分为肝郁脾虚型、肝郁气滞型、肝肾阴虚型、心脾两虚型,其中治疗组30例,予逍遥散...     

腹腔镜治疗胃食管反流性疾病的临床研究

目的:探讨腹腔镜治疗胃食管反流性疾病的安全性和疗效。方法:回顾分析2004年至2009年为83例患者行腹腔镜手术的临床资料。结果:83例手术均获成功,手术时间30~60min,平均45min,出血5~20ml,术后24h进流质饮食,临床症状消失,术后无并发症发生,住院3~8d,平均5d。随访6个月~5年无复发。结论:应用腹腔镜治疗胃食管反流性疾病安全、可靠,具有广阔的应用前景。     

中西医结合治疗高位马蹄形肛周脓肿80例

2007 - 01-2011 - 05,我们在主病灶切开挂线的基础上,采用对口引流术,术后应用中药熏洗及中药换药治疗高位马蹄形肛周脓肿80例,结果如下. 1资料与方法 1.1一般资料本组80例均为我院外五科住院患者,男56例,女24例;年龄15 ～ 65岁,平均(40±1.6)岁;病程21～ 35 d,平均(28±0.9)d.     

Experimental study on the effect of An-pressing and Rou-kneading Huantiao (GB 30) on certain brain nuclei of pleasure circuits in rats with chronic neuralgia

Objective

To explore the central neurobiological mechanisms of pleasure effect on rats with neuralgia treated by tuina manipulations of An-pressing and Rou-kneading Huantiao (GB 30).

Methods

A total of 64 male Sprague-Dawley (SD) rats were used in this study. Eighteen rats were randomly selected as a normal group, and the other 46 rats were used to duplicate the chronic constriction injury (CCI) model. Ten rats failed in modeling and 36 rats succeeded. These 36 rats were then randomly divided into a model group and a tuina group, with 18 rats in each group. The rats in the normal group and the model group did not receive any interventions, while those in the tuina group received An-pressing and Rou-kneading Huantiao (GB 30), 1 min for each time, once a day, 3 weeks in total. Heating tests were evaluated to observe the change of pain-sensitivity score before intervention, 1 week after intervention, 2 weeks after intervention, and 3 weeks after intervention. After 1 week of intervention, 2 weeks of intervention, and 3 weeks of intervention, 6 rats were randomly selected from each group respectively for brain extraction. The change of Nissl’s body and β-endorphin in the accumbens nucleus as well as amygdaloid nucleus of pleasure circuits, and pro-opiomelanocortin (POMC) in the arcuate nucleus were analyzed by methods of histochemistry and molecular biology.

Results

After modeling, the pain-sensitivity scores of the tuina group and the model group were statistically different from the score of the normal group (both P<0.05). After An-pressing and Rou-kneading Huantiao (GB 30) for one week, the pain-sensitivity score of the tuina group had statistical difference compared with that of the model group (P<0.05). At each different time point: the amounts of Nissl’s body in accumbens nucleus and amygdaloid nucleus of the tuina group were significantly more than those of the model group (all P<0.01). Besides, the numbers of β-endorphin immunoreactive cells in the accumbens nucleus and amygdaloid nucleus of the rats in the tuina group were significantly higher than those in the model group (all P<0.01), and so was the expression of POMC in arcuate nucleus (all P<0.01).

Conclusion

An-pressing and Rou-kneading Huantiao (GB 30), where the sciatic nerve is ligated, can reduce pain-sensitivity score and increase pain tolerance value of rats with chronic neuralgia. It can increase the activity of neurons in accumbens nucleus and amygdaloid nucleus of pleasure circuits, which indicates that the analgesia effect of tuina therapy may correlate with pleasure effect, and also reveals a part of neurobiological mechanisms of neuralgia.

     

川芎嗪与低分子肝素治疗不稳定心绞痛评价

不稳定心绞痛 (UAP)是急性冠状动脉综合征的一种 ,是一种严重并具有潜在危险的重症状态 ,易导致急性心肌梗死和猝死。笔者自 1998年 2月～ 2 0 0 0年 11月对确诊的 UAP患者给予川芎嗪、低分子肝素钙治疗 ,疗效确切 ,现报道如下。1　临床资料1.1　治疗对象。凡符合下列标准的病例随机进入治疗研究对象 :1符合 WHO不稳定心绞痛的诊断标准 ;2无急性心肌梗死的酶学改变 ;3无抗凝集药忌用者。总共 38例。分为治疗组 2 0例 ,男 14例 ,女 6例 ;平均年龄 5 8.6岁 ;其中初发劳累性心绞痛 8例 ,恶化劳累性心绞痛 6例 ,自发性心绞痛 4例 ,梗死后心…     

帕金森病相关蛋白的作用研究进展

<正>帕金森病(Parkinsondisease,PD)是第二常见的神经变性疾病。其主要临床特征是静止性震颤、肌强直、运动减少和姿势平衡障碍等;主要病理改变是中脑黑质多巴胺能神经元进行性变性坏死,残存神经元中Lewy小体形成。5-10%帕金森病患者有家族史。虽然,大部分帕金森病病例为散发型,但阐明家族性帕金森病的分子机理对于整个帕金森病发病机制的研究有着重大的意义。本文就目前已经明确的帕金森病相关蛋白的作用机理作一综述。一、α-synucleinSCNA(PAPK1)是第一个被发现的与常染色体显性遗传帕金森病有关的基因,其编码蛋白α-synuclein。α-synuelein是一种高度保守的蛋白质,高度耐热,为小分子酸性蛋白质,含有140个氨基酸。α-synuclein的序列可以分为三个结构域高度保守的氨基端包含11个氨基酸不完全的6拷贝重复,中间部分是被称为非口-淀粉样蛋白(NAC)的疏水结构域,羧基端没有固定的结构原件。α-synuclein在中枢神经系统内(特别是突触前膜)丰富表达,定位于核周。它是一种可溶的,天然伸展的蛋     

推拿结合物理因子治疗臂丛神经损伤神经病理性疼痛的临床疗效观察

目的：观察推拿结合物理因子治疗臂丛神经损伤术后神经病理性疼痛的临床疗效.方法：采用随机、对照的研究方法,将50例臂丛神经损伤术后疼痛患者随机分为推拿结合物理因子治疗组和单纯物理因子对照组,采用McGill疼痛询问量表评估两组疼痛情况,进行疗效比较.结果：50例病例全部完成治疗,无脱落病例.完成全部治疗后,两组PRI感觉项评分有统计学意义（P〈0.05）,PPI、VAS评分有显著性差异（P〈0.01）.推拿结合物理因子治疗组治疗前后比较,PRI感觉项、PRI情绪项评分有统计学意义（P〈0.05）,其余各项评分有显著性差异（P〈0.01）.结论：推拿结合物理因子治疗臂丛神经损伤术后神经病理性疼痛优于单纯物理因子治疗.