TGF-β1、Smad 3和P-Smad 2/3在病理性瘢痕中的表达

目的检测瘢痕疙瘩、增生性瘢痕和正常皮肤组织中转化生长因子-β1(TGF-β1)、Smad3和P-Smad2/3的表达情况,探讨上述细胞因子对瘢痕产生的重要性及影响。方法采用免疫组织化学的方法检测上述3种细胞因子在3种不同组织共36例标本中的表达,ImagePro-Plus6.0软件进行阳性面积测量和细胞计数。结果TGF-β1在瘢痕疙瘩和增生性瘢痕中均为增强高表达,而在正常皮肤中几乎不表达;Smad3在三组标本间表达水平无显著性差异;P-Smad2/3在瘢痕疙瘩中表达最强,增生性瘢痕次之,正常皮肤组织中最低。结论TGF-β1表达增强是病理性瘢痕产生的重要原因,P-Smad2/3的表达水平则可认为与瘢痕增生程度密切相关。     

从《伤寒论》的六经辨证看帕金森病的中医药治疗

帕金森病的中西医治疗目前均未取得满意疗效，笔者从六经辨证的实质、结合帕金森病的临床表现，探讨以六经辨证理论为指导、以六经厥阴病理为原则、辨证治疗和辨病治疗相结合的中医药治疗帕金森病的有效疗法。     

心理干预对人工流产的效果观察

目的：评价心理干预在实施无痛人工流产术中的应用价值。方法：将无病人工流产960例进行分组观察，其中给予心理干预组585例（观察组），只行常规护理375例（对照组）。结果：观察组术前、术中、术后的血压、心率较对照组低。观察组镇痛的总有效率为100%，无痛率为89．23％；对照组为98．4％，无痛率为30．93％。观察组人流并发症显著低于对照组。结论：心理干预用于人工流产术可提高患者的痛阈，降低人工流产的并发症。     

显微外科技术针头支架法输精管吻合术42例分析

目的探讨输精管吻合术的新方法及复育效果。方法通过显微外科技术针头I临时支架固定法，行输精管吻合术42例。结果42例输精管吻合术，术后随访，检查精液有精子36例，术后再通率85．7％；配偶受孕25例，复孕率59．5％。结论应用显微外科技术针头临时支架法行输精管吻合术，可有助于提高输精管再通率复育率。     

Surgical strategy of one stage surgery of anterior release combined with posterior correction in treatment of severe scoliosis

Objective: Severe scoliosis refers to scoliosis with serious and stiff curve. It always combins with trunk imbalance in coronal and sagittal contour. Besides complex pathological changes, cardiopulmonary deficits and other concomitant diseases increase treatmental difficulties. So the treatment of severe scoliosis is always a great challenge to spine surgeon. Methods :Thirty-six patients with severe scoliosis received one stage posterior correction followed by anterior release during July 1997 to January 2003, including 9 males and 27 females. Mean age was 17.2 years. Of them, 33 was idiopathic scoliosis and 3 was neurofibromatosis scoliosis( Cobb angle: 85-116 degree); 20 cases were abnormal in sagital plane. Three-dimensional devised instrumentation were applied such as CD, CD-Horizon, TSRH or Isola in posterior procedure followed by anterior release during the same anesthesia. 31 cases of this group received thorac icplasty. Results: The correction in the frontal plane achieved an average of 48.5%. In the sagittal plane, the pathological shape of the spine was reduced and distinctly ameliorated. 80. 6% of the patients maintained or achieved balance of sagittal plane. There were no complications of severe neurological deficit, hook displacement, rod broken, and deep infection at follow-up. One case occurred traumatic pleurisy after operation and another appeared pseudarthrosis 2 years later. One case demonstrated imbalance 11 months after operation. One patient was presented loss of correction more than 10 degree at one year follow-up and 5.2 degree in average. Conclusion:The study indicates that the one stage posterior correction combined with anterior release in treatment of severe scoliosis can achieve satisfactory correction. Appropriate choice of cases, preoperational detailed assessment and application of SEP and wake-up test during operation can possibly reduce severe complication. The long-term outcomes still need further observation.     

原发性血色病疑似病例1例

原发性血色病是一种临床上少见的遗传性疾病，在我国仅有零星个案报道。我院2003年12月收治疑似病例1例，报告如下。     

禽流感过后的反思

禽流感首次警报过后一年了，我们能松口气了吗?最近《新科学家》发表了一篇社论，它警告我们虽然迄今为止禽流感病毒H5N1还难以传染给人，但是人们一旦感染上此病毒则死亡率高迭75％。此外，使人担心的是病毒能变得在人与人之间非常容易传播，若是如此则地球上1/3的人在数个月内染病；更让人担心的是，根据病毒学家的观察发现，这种病毒无论死活都具有传染性。请估算一下：若地球上1/3的病毒感染者将有3／4死亡，也就是说将有15亿的人死亡。这个可怕的结果令病毒学家们寝食难安。