子宫颈电圈切除术诊断和治疗子宫颈上皮内瘤变的临床价值

Objective To investigate the clinical values of loop electrosurgical excision procedure (LEEP) in diagnosis and treatment of cervical intraepithelial neoplasia(CIN). Methods Fifty-two patients with cervical intraepithelial neoplasia underwent LEEP following cytology, colposcopy and multiple biopsies, were treated by LEEP. The cure rate, the operative time, bleeding volume and patients reaction of LEEP to the cervical intraepithelial neoplasia were investigated during the follow-up. Results The effective rate was 98.07 % in the patients treated by LEEP. The effective rate was 100 % in the patients in grade CIN Ⅰ or CIN Ⅱ by LEEP. No patients in grade CIN Ⅰ and Ⅱ had recurrence during the follow-up 1 year. The mean operative time was 7.8 minutes. The mean bleeding volume was 10 ml. No secondary bleeding and post-operative infection occurred. All these surgical specimens were checked successfully for pathology diagnosis. Conclusion The advantages to use the LEEP to manage cervical intraepithelial neoplasia include its simpleness to handle, short operative time,less bleeding, less vaginal discharge, safety, and high cure rate. LEEP can offer intact sample for pathological diagnosis. LEEP electrotome is a very ideal therapy for the cervical intraepithelial neoplasia, and can block the development of precancerosis to infiltrating carcinoma effectively.     

子宫颈电圈切除术诊断和治疗子宫颈上皮内瘤变的临床价值

目的探讨高频电波刀行子宫颈电圈切除术（LEEP）诊治子宫颈上皮内瘤变（CIN）的临床应用价值。方法对经子宫颈脱落细胞学检查、阴道镜下子宫颈多点活检病理初步诊断为CIN的患者52例,采用LEEP治疗,对LEEP术后患者随访同时观察手术时间、出血量及术后疗效。结果LEEP对患者治愈率达98．07％（51／52）,对于CINⅠ、Ⅱ级患者治愈率达100％,术后定期随诊,术后1年无CIN复发。平均手术时间7．8min,出血量10ml,无继发性出血和感染的发生,手术标本经病理学检查明确诊断。结论LEEP治疗CIN手术操作简单、时间短、出血少、术后阴道排液少,安全有效,成功率高,且可提供完整的病理标本,是CIN非常理想的诊断与治疗方法,可有效阻断癌前病变发展为浸润癌。     

喜树碱对炎症诱导的多巴胺能神经元损伤的保护作用

目的探讨喜树碱对炎症诱导的多巴胺能神经元(DN)损伤的保护作用及其可能机制。方法建立DN培养体系及混合培养体系,观察不同干预下DN的生存率、酪氨酸羟化酶(TH)mRNA表达及肿瘤坏死因子α(TNF-α)、一氧化氮(NO)、白细胞介素6(IL-6)、胶质源性神经生长因子(GDNF)含量的变化。结果在DN培养体系中,喜树碱10mg/L较对照组明显促进DN凋亡(P<0.05)。在混合培养体系中,与对照组比较,不同浓度喜树碱均增加TH阳性细胞数和THmRNA的表达(P<0.05),降低NO、TNF-α及IL-6的含量(P<0.05),但只有喜树碱10mg/L能促进DN的凋亡(P<0.05)。结论适量的喜树碱能抑制星形胶质细胞分泌炎性介质,保护神经元。     

87 例口腔颌面部外伤的临床分析

目的 探讨口腔颌面部外伤患者的致伤原因、组织损伤特点以及临床救治的方法与体会.方法 收集我科2006-06～2012-06间收治的87例口腔颌面部外伤患者资料进行汇总分析.结果 好发年龄21～40岁59例,占67.82％.交通伤40例,占45.98％,在致伤原因中属首位.除1例粉碎性骨折患者愈合较差外,其余均取得满意疗效.结论 口腔颌面部是人体最容易受外力导致损伤的主要部位,伤后迅速准确地判断伤情、抢救生命是关键,同时,及时地清创缝合及骨折复位固定也起到至关重要的作用.因此,应加强预防,减少外伤的发生.     

中西医结合治疗慢性盆腔炎临床观察

目的:观察中成药桂枝茯苓浓缩丸治疗慢性盆腔炎的临床疗效.方法:选择2005年2月～2008年2月就诊我院妇科门诊并确诊的慢性盆腔炎病例580例,随机分为两组.研究组:280例均服用桂枝茯苓浓缩丸,每日2次.每次6丸,经期停服改为静滴新型广谱抗生素及替硝唑7天,3个月为一疗程.对照组:280例盆腔炎患者均采用于月经期静滴新型广谱抗生素及替硝唑7天.3个疗程后进行疗效比较.结果:研究组总有效率为97.86%,对照组总有效率为83.93%,两组相比临床疗效有显著性差异(P＜0.05).结论:桂枝茯苓浓缩丸是治疗慢性盆腔炎的理想中成药,中西医结合治疗慢性盆腔炎较单一用抗生素治疗方法效果好,具有广阔的应用前景,值得临床进一步推广使用.     

中西医结合治疗小儿鼻窦炎的疗效观察

目的：观察中西医结合治疗小儿鼻窦炎的临床疗效。方法选取慢性鼻窦炎患儿共120例作为研究对象,根据入院顺序将患儿分为观察组和对照组,每组各60例。对照组口服头孢他美酯片、氯雷他定颗粒,并使用活性银离子抗菌液喷鼻。观察组在对照组基础上加服苍耳子鼻炎滴丸。2周后比较两组临床疗效。结果观察组痊愈率、总有效率分别为30．00％（18/60）、63．33％（38/60）,对照组分别为15.00％（9/60）、41．67％（25/60）,差异均有统计学意义（χ2＝3．87、5．65,均P＜0．05）。结论中西医结合治疗小儿鼻窦炎的临床疗效优于单纯采用西医治疗,安全可靠,值得在临床上进一步推广。     

中西医结合治疗小儿支气管哮喘合并反复呼吸道感染75例疗效观察

目的:观察中西医结合治疗小儿支气管哮喘合并反复呼吸道感染的临床疗效。方法:将支气管哮喘合并反复呼吸道感染患儿150例按随机数字表法分为2组各75例。对照组急性期抗感染、糖皮质激素吸入治疗,缓解期仅给予糖皮质激素吸入治疗;观察组缓解期在对照组基础上给予中药固本喘舒方口服治疗。观察并记录2组患儿的咳嗽天数、喘息发作天数、呼吸道感染次数以及食欲、睡眠情况等,比较免疫球蛋白的变化情况,观察2组临床疗效。结果:治疗后,观察组患儿的咳嗽天数、喘息发作天数、呼吸道感染次数等指标均明显减少,食欲、睡眠情况明显改善,且均优于对照组(P0.01)。治疗后观察组的IgA、IgG等免疫球蛋白的含量均较治疗前升高(P0.01),并且优于对照组(P0.05)。临床总有效率观察组为96.00%,高于对照组的80.00%,差异具有显著性意义(P0.05)。结论:中西医结合应用于小儿支气管哮喘合并反复呼吸道感染的治疗,可明显缓解患儿的咳喘,疗效确切,值得临床推广使用。     

子宫颈电圈切除术诊断和治疗子宫颈上皮内瘤变的临床价值

Objective To investigate the clinical values of loop electrosurgical excision procedure (LEEP) in diagnosis and treatment of cervical intraepithelial neoplasia(CIN). Methods Fifty-two patients with cervical intraepithelial neoplasia underwent LEEP following cytology, colposcopy and multiple biopsies, were treated by LEEP. The cure rate, the operative time, bleeding volume and patients reaction of LEEP to the cervical intraepithelial neoplasia were investigated during the follow-up. Results The effective rate was 98.07 % in the patients treated by LEEP. The effective rate was 100 % in the patients in grade CIN Ⅰ or CIN Ⅱ by LEEP. No patients in grade CIN Ⅰ and Ⅱ had recurrence during the follow-up 1 year. The mean operative time was 7.8 minutes. The mean bleeding volume was 10 ml. No secondary bleeding and post-operative infection occurred. All these surgical specimens were checked successfully for pathology diagnosis. Conclusion The advantages to use the LEEP to manage cervical intraepithelial neoplasia include its simpleness to handle, short operative time,less bleeding, less vaginal discharge, safety, and high cure rate. LEEP can offer intact sample for pathological diagnosis. LEEP electrotome is a very ideal therapy for the cervical intraepithelial neoplasia, and can block the development of precancerosis to infiltrating carcinoma effectively.     

蒙脱石散剂联合中药治疗小儿慢性腹泻的效果观察

目的 探讨中西医结合治疗小儿慢性腹泻的临床疗效.方法 选择本院110例腹泻患儿研究对象,随机分为两组,对照组给予蒙脱石散剂治疗,观察组在此基础上加用中药治疗,比较两组患者的临床疗效.结果 对照组患者治愈20例,有效16例,无效19例,有效率为65.5％;观察组患者治愈30例,有效21例,无效4例,有效率为94.4％;观察组有效率高于对照组（P＜0.05）.两组患者治疗前的CD4＋、CD8＋、CD4＋/CD8＋等指标差异均无统计学意义（均P＞ 0.05）,但治疗后观察组的以上指标均得到显著改善（P＜0.05）,且观察组的效果优于对照组（P＜0.05）.结论 蒙脱石散剂联合中药治疗小儿慢性腹泻疗效确切,副作用小,可有效缩短病程、促进患儿消化系统功能恢复.