紫外分光光度法测定奥硝唑片的含量

建立紫外分光光度法测定奥硝唑片中奥硝唑含量的方法.采用紫外分光光度法,检测波长277 nm.奥硝唑的线性范围为5～30μg/ml,r＝0.9999,平均回收率为99.3%,RSD为0.5%.该方法操作简便,结果准确.     

上海市江宁街道20岁及以上人群干眼的流行病学调查

Objective To investigate the prevalence of dry eye in populations equal or over 20 years old in Jiangning District, Shanghai, China. Methods This was a cross-sectional study. From September 2008 to January 2009, 6 small districts including 21 102 people of Jiangning District were randomly selected as survey venues by Department of Ophthalmology in First People's Hospital affiliated to Shanghai Jiaotong University. Then, 1266 people as the selected residents were enrolled, which was figured out through the random cluster sampling procedure. Every participant completed dry eye questionnaire, the ocular surface disease index (OSDI), and a series of examination including slit-lamp microscope, tear-film break-up time (BUT), Schirmer Ⅰ test, and fluorescein staining of the cornea (F1). The diagnosis of dry eye was referred to the well-accepted domestic diagnostic criteria. The SPSS11.0 software was used to analyze the database, t test,χ2 test, one-way-ANOVA and Logistic regression were used for analysis. Results One thousand and eighty five residents finally took part in this study, and the inclusion ratio was 85.70%. Three hundred and twenty six individuals, including 101 men and 225 women, were diagnosed as dry eye, and the prevalence rate was 30.05%. The prevalence of dry eye in the female (33.78%) was higher than that of the male (24.11%) (χ2=11.46, P<0.01). The prevalence of dry eye in people over 50 years old was higher than that under 50 years (χ2=94.50, P<0.01). The figure of Schirmer Ⅰ test and BUT decreased in elder people, at the same time the scores of F1 and MGD increased. Meanwhile, the score of OSDI in dry eye patients was significantly higher than that in non-dry eye individuals. The relative risk factors of dry eye were gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs. Conclusions The prevalence of dry eye in female is higher than that in the male. And the prevalence of dry eye increases following the aging process. Relative risk factors of dry eye are gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs.     

军人自杀意念量表的初步编制

目的 编制适用于我国军人的自杀意念量表.方法 在文献分析的基础上,结合国内外已有的自杀意念量表,通过专家评定等方法,构建了中国军人自杀意念的理论维度,并在此基础上编制了军人自杀意念量表,选择海军、陆军、空军共900名军人作为样本进行测试.运用因素分析的方法验证了军人自杀意念的理论维度,并对量表进行了信效度分析.结果 军人自杀意念由3个维度构成,包括绝望、抑郁和乐观.各维度与总分的相关系数在0.679～0.913之间,该量表和自杀可能性量表(SPS)之间的相关为0.620,全量表同质信度Cronbach仪系数为0.904,各维度的Cronbach α系数在0.759～0.894之间.结论 该量表具有良好的信效度,可以作为中国军人自杀意念的评定工具.     

上海市江宁街道20岁及以上人群干眼的流行病学调查

Objective To investigate the prevalence of dry eye in populations equal or over 20 years old in Jiangning District, Shanghai, China. Methods This was a cross-sectional study. From September 2008 to January 2009, 6 small districts including 21 102 people of Jiangning District were randomly selected as survey venues by Department of Ophthalmology in First People's Hospital affiliated to Shanghai Jiaotong University. Then, 1266 people as the selected residents were enrolled, which was figured out through the random cluster sampling procedure. Every participant completed dry eye questionnaire, the ocular surface disease index (OSDI), and a series of examination including slit-lamp microscope, tear-film break-up time (BUT), Schirmer Ⅰ test, and fluorescein staining of the cornea (F1). The diagnosis of dry eye was referred to the well-accepted domestic diagnostic criteria. The SPSS11.0 software was used to analyze the database, t test,χ2 test, one-way-ANOVA and Logistic regression were used for analysis. Results One thousand and eighty five residents finally took part in this study, and the inclusion ratio was 85.70%. Three hundred and twenty six individuals, including 101 men and 225 women, were diagnosed as dry eye, and the prevalence rate was 30.05%. The prevalence of dry eye in the female (33.78%) was higher than that of the male (24.11%) (χ2=11.46, P<0.01). The prevalence of dry eye in people over 50 years old was higher than that under 50 years (χ2=94.50, P<0.01). The figure of Schirmer Ⅰ test and BUT decreased in elder people, at the same time the scores of F1 and MGD increased. Meanwhile, the score of OSDI in dry eye patients was significantly higher than that in non-dry eye individuals. The relative risk factors of dry eye were gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs. Conclusions The prevalence of dry eye in female is higher than that in the male. And the prevalence of dry eye increases following the aging process. Relative risk factors of dry eye are gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs.     

奥硝唑注射液的处方及制备工艺

奥硝唑[1,2 ] 是一种强力抗厌氧菌及抗原虫感染的药物 ,也是继甲硝唑后新研制成的疗效更高[3] 、疗程更短、体内分布更广、应用范围更宽、副作用小的硝基咪唑类衍生物。目前 ,我国在临床上已应用于治疗厌氧菌感染 (腹膜炎、子宫内膜炎、卵巢脓肿、细菌性败血病、脓胸、肺脓肿、急性溃疡性龈炎等 )和原虫(滴虫、阿米巴虫、蓝氏贾第鞭毛虫 )感染性疾病 ,效果显著。本试验对奥硝唑的处方和制备工艺进行初步探讨如下。1　奥硝唑注射液的结构和处方奥硝唑结构 :　　奥硝唑注射液处方 :奥硝唑 5 .0ｇ ,氯化钠 8.3ｇ ,加注射用水至 10 0 0ｍｌ。2　…     

健胃愈疡片治疗消化性溃疡314例临床疗效与安全性

目的：观察健胃愈疡片治疗消化性溃疡的临床疗效与安全性。方法：临床确诊的消化性溃疡患者按先后顺序随机入组，试验组314例口服健胃愈疡片，对照组132例口服雷尼替丁胶囊，两组均治疗4周为一疗程。结果：健胃愈疡片治疗消化性溃疡，溃疡痊愈率为59．87％，有效率为91．40％，痊愈患者6个月后溃疡复发率为12．24％，治疗后疼痛缓解率为93．00％，疼痛消失率为79．33％；对照组溃疡痊愈率为58．33％，有效率为89．39％，痊愈患者6个月后溃疡复发率为14．04％，治疗后疼痛缓解率为88．46％，疼痛消失率为72．30％；两组比较，差异无统计学意义。两组均未发现与药物相关的不良反应。结论：健胃愈疡片治疗消化性溃疡疗效确切，安全可靠。     

上海市江宁街道20岁及以上人群干眼的流行病学调查

Objective To investigate the prevalence of dry eye in populations equal or over 20 years old in Jiangning District, Shanghai, China. Methods This was a cross-sectional study. From September 2008 to January 2009, 6 small districts including 21 102 people of Jiangning District were randomly selected as survey venues by Department of Ophthalmology in First People's Hospital affiliated to Shanghai Jiaotong University. Then, 1266 people as the selected residents were enrolled, which was figured out through the random cluster sampling procedure. Every participant completed dry eye questionnaire, the ocular surface disease index (OSDI), and a series of examination including slit-lamp microscope, tear-film break-up time (BUT), Schirmer Ⅰ test, and fluorescein staining of the cornea (F1). The diagnosis of dry eye was referred to the well-accepted domestic diagnostic criteria. The SPSS11.0 software was used to analyze the database, t test,χ2 test, one-way-ANOVA and Logistic regression were used for analysis. Results One thousand and eighty five residents finally took part in this study, and the inclusion ratio was 85.70%. Three hundred and twenty six individuals, including 101 men and 225 women, were diagnosed as dry eye, and the prevalence rate was 30.05%. The prevalence of dry eye in the female (33.78%) was higher than that of the male (24.11%) (χ2=11.46, P<0.01). The prevalence of dry eye in people over 50 years old was higher than that under 50 years (χ2=94.50, P<0.01). The figure of Schirmer Ⅰ test and BUT decreased in elder people, at the same time the scores of F1 and MGD increased. Meanwhile, the score of OSDI in dry eye patients was significantly higher than that in non-dry eye individuals. The relative risk factors of dry eye were gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs. Conclusions The prevalence of dry eye in female is higher than that in the male. And the prevalence of dry eye increases following the aging process. Relative risk factors of dry eye are gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs.     

上海市江宁街道20岁及以上人群干眼的流行病学调查

Objective To investigate the prevalence of dry eye in populations equal or over 20 years old in Jiangning District, Shanghai, China. Methods This was a cross-sectional study. From September 2008 to January 2009, 6 small districts including 21 102 people of Jiangning District were randomly selected as survey venues by Department of Ophthalmology in First People's Hospital affiliated to Shanghai Jiaotong University. Then, 1266 people as the selected residents were enrolled, which was figured out through the random cluster sampling procedure. Every participant completed dry eye questionnaire, the ocular surface disease index (OSDI), and a series of examination including slit-lamp microscope, tear-film break-up time (BUT), Schirmer Ⅰ test, and fluorescein staining of the cornea (F1). The diagnosis of dry eye was referred to the well-accepted domestic diagnostic criteria. The SPSS11.0 software was used to analyze the database, t test,χ2 test, one-way-ANOVA and Logistic regression were used for analysis. Results One thousand and eighty five residents finally took part in this study, and the inclusion ratio was 85.70%. Three hundred and twenty six individuals, including 101 men and 225 women, were diagnosed as dry eye, and the prevalence rate was 30.05%. The prevalence of dry eye in the female (33.78%) was higher than that of the male (24.11%) (χ2=11.46, P<0.01). The prevalence of dry eye in people over 50 years old was higher than that under 50 years (χ2=94.50, P<0.01). The figure of Schirmer Ⅰ test and BUT decreased in elder people, at the same time the scores of F1 and MGD increased. Meanwhile, the score of OSDI in dry eye patients was significantly higher than that in non-dry eye individuals. The relative risk factors of dry eye were gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs. Conclusions The prevalence of dry eye in female is higher than that in the male. And the prevalence of dry eye increases following the aging process. Relative risk factors of dry eye are gender, age, wearing contact lens, long-time using of eye solutions, taking anti-allergy drugs.     

结膜印迹细胞学与干眼症状和体征的相关性

目的 分析丫啶橙荧光染色结膜印迹细胞学（CICAO）检查与干眼症状和体征的相关性。方法 选取152例（303眼）干眼患者和60名（120眼）正常对照者,采集干眼患者症状（干涩感、异物感、烧灼感、眼睛红、分泌物增多、眼睑沉重感、视疲劳、畏光、流泪、痒感、眼痛、视力波动）,对所有受试者进行泪液分泌试验（SIt）、泪膜破裂时间(BUT)、角膜荧光素钠染色(FL)、虎红染色(RB)及CICAO检查。采用Spearman等级相关分析检验CICAO与干眼症状及SIt、BUT、FL和RB的相关性。结果 CICAO与干眼症状中的干涩感、流泪、眼痛有显著相关性（r=0.337, r=－0.278, r=0.395;均P＜0.05)。CICAO与RB、SIt、BUT、FL均有显著相关性（r=0.757,r=－0.668,r=－0.549,r=0.428;均P＜0.01)。结论 CICAO与干眼症状的相关性较低,与RB、SIt、BUT、FL均具有显著相关性。CICAO可为干眼的临床分级诊断和治疗提供可靠的依据。