胰岛素强化治疗对严重创伤患者炎性反应及预后的影响

Objective To investigate the effects of intensive insulin therapy on inflammatory re-sponse and prognosis of patients with severe trauma. Methods Eighty severely injured patients were di-vided into intensive insulin therapy group (n = 40, IT) and routine therapy group (n = 40, RT) in random pair. At the time of admission, a continuous infusion of insulin (2 -4 U/h) was pumped into the patients of IT group to maintain blood glucose level at 6 -8 mmol/L. Patients in RT group were given routine treatment without administration of insulin. Fever, organ injury, and mortality of patients in 2 groups were recorded. Venous blood was drawn from patients of 2 groups on the morning of post treatment day (PTD) 1, 3, 5, and 7. Values of TNF-α, C-reactive protein (CRP), IL-2, and IL-10 in plasma were assayed. Results High fever appeared in 9 patients in IT group, and WBC exceeded 10.0×109 for more than 3 days in 17 patients in this group, versus 20 and 29 patients respectively in RT group. Dysfunction of 1 organ appeared in 31 pa-tients in IT group and 30 patients in RT group. Dysfunction of 3 organs appeared in 10 patients in IT group and 19 patients in RT group. Dysfunction of 4 organs appeared in 7 patients in IT group and 12 patients in RT group. In IT group, 4 patients died within 3 post-injury day (PID), and 1 patient died after PID 3 (total case fatality: 12.5% ). In RT group, 5 patients died within 3 PID, and 4 patient died after PID 3 (total case fatality: 22.5%). Plasma levels of TNF-α and CRP of patients in IT group were significantly lower than those of patients in RT group on PID 3 - 7 ( P<0.05 or P<0.01 ), while levels of IL-2 and IL-10 of patients in IT group were significantly higher than those of patients in RT group ( P<0.05 or P<0.01 ). Plasma levels of TNF-α ( 1.3±0.6 μg/L) and CRP (55±16 mg/L) of patients in IT group on PTD 7 were lowered to the trough level, and they were significantly lower than those of patients in RT group (3.0±0.8μg/L, 89±20 mg/L, respectively, P <0.01 ). Conclusions Intensive insulin therapy can mitigate systemic inflammatory response and improve prognosis of patients with severe trauma.     

颈动脉粥样硬化斑块内MCP-1表达的研究

目的观察颈动脉粥样硬化(AS)斑块内单核细胞趋化蛋白-1(MCP-1)的mRNA和抗原的表达情况。方法分别应用原位杂交和免疫组织化学法测定颈AS斑块中MCP-1mRNA和抗原表达。结果相对于正常动脉内膜,颈AS病变内膜MCP-1阳性细胞数明显增多(P<0.05)。其中颈AS严重病变肩区阳性细胞数最多,以单核-巨噬细胞为主。结论MCP-1与颈AS发生密切相关。     

婴儿不宜吃蛋清

有些年轻的父母喜欢喂蛋清给婴儿吃,殊不知这样做有损婴儿的健康。因为半岁前婴儿的消化系统发育还不完善,肠壁的通透性     

恶性肿瘤在治疗过程中并发的伪膜性肠炎的护理

伪膜性肠炎是金黄色葡萄球菌所致的急性肠道疾病 ,临床上常见于应用广谱抗菌素的患者 ,也是化疗过程中一种极为严重的并发症 ,死亡率很高。我院曾遇到过 1例化疗并发伪膜性肠炎、麻痹性肠梗阻的患者 ,经治疗痊愈。现将本例临床情况及护理经过简要介绍如下。病例简介 :女 ,38岁。因不规则阴道流血 4 0余天 ,气急 3ｄ而急诊入院。全身情况很差 ,急性重病容 ,呼吸急促。查体 :子宫孕 10周大 ,双侧附件均增厚 ,左侧有一鸭蛋大小之包块。胸片显示双肺布满阴影。妊娠试验 1 5 0阳性。诊断为子宫绒毛膜上皮癌 ,双肺广泛转移 ,盆腔转移。入院第2ｄ开…     

赴美领养儿童旅行期间疾病的调查与分析

赴美领养儿童(以下简称领养儿童)是由美国公民通过国际领养组织收养的儿童群体.这些儿童大多数是婴幼儿,从全国各地乘公共交通工具到达广州,完成移民签证程序后,由广州乘国际航班到美国,并在美国的家庭生活.     

曲马多对硬膜外麻醉寒战反应的临床观察

将 6 0例硬膜外麻醉下行下肢手术中出现寒战反应的患者随机分为 3组 ,各 2 0例 ,分别静脉注射曲马多1mg/kg(A组 )、哌替啶 0 .5mg/kg(B组 )、咪达唑仑 0 .0 5mg/kg(C组 )。记录用药后寒战停止所需时间。结果 3组消除寒战的有效率分别为 95 %、90 %、6 0 % ;A、B两组与C组比较 ,治疗有效率有显著性差异 (P <0 .0 5 )。表明曲马多 (1mg/kg)、哌替啶 (0 .5mg/kg)和咪达唑仑 (0 .0 5mg/kg)均可用于硬膜外麻醉期间的寒战治疗 ,但曲马多起效快、镇静作用弱、安全性高 ,是治疗硬膜外寒战的可选药物     

五常法在病区环境管理中的应用

目的　营造安全、舒适、高效、整洁的工作环境。方法　先试点 ,再全面推广。试点科室以QC小组活动形式开展 ,活动过程遵循PDCA循环法 :先进行全员培训 ,再对本病区的环境进行现状调查、评估、分析 ,找出要因论证 ,制定对策并实施五常法。结果　规范病区环境管理 ,物品的分类、定点放置规范 ,达到目视管理的要求。职工重视工作现场的安全 ,使五常法由环境品质扩展到人的行为品质。提高了工作效率 ,3 0S内能准确找到所需物品。塑造了良好的医院形象 ,提高了医院的竞争力。结论　五常法是规范病区环境最简便、最有效的方法     

香烟烟雾吸入对大鼠局灶性脑缺血后梗死灶的影响

目的 观察香烟烟雾吸入对大鼠局灶性脑缺血后梗死灶的影响，探讨其机制。方法 建立吸烟大鼠模型。用TTC染色法测定梗死灶体积，检测大鼠局灶性脑缺血后神经功能缺陷评分及梗死灶体积占同侧半球百分比。结果 除戒烟组外各吸烟组大鼠神经功能缺陷评分及梗死灶体积与对照组相比显著增加，吸烟4周、8周及12周依次增加。戒烟组神经功能评分及梗死体积明显低于吸烟4周组，与对照组无显著差别。结论 吸烟可加重大鼠局灶性脑缺血后脑组织损害，且随着吸烟时间增加而加重，戒烟可使这种脑损害得到一定程度的恢复。