肝细胞生长因子在慢性肾脏病的研究进展

近年来，肝细胞生长因子在肾脏疾病中的作用日益受到重视，本文就肝细胞生长因子在慢性肾衰竭／肾纤维化中的作用及其作用机制作一综述，提示肝细胞生长因子在治疗肾纤维化方面可能具有广阔的前景。     

获得性肾囊肿危险因素的配对病例对照研究

目的 :探讨影响获得性肾囊肿 (ARC)发病的危险因素。方法 :回顾性分析 5 3例ARC患者临床资料 ,进行 1∶1配对病例对照研究 ,并建立回归模型分析其危险因素 ,在α =0 .0 5水平确定其危险因素。结果 :经过单因素条件回归、多因素条件Logistic回归、逐步条件回归分析 ,结果显示肌酐清除率 (Ccr)水平 (OR =0 .4 98,P =0 .0 112 ,β =- 0 .6 976 2 )和年龄 (OR =2 .0 93,P =0 .0 2 71,β =0 .7385 2 )与ARC有显著性 (P <0 .0 5 )关联。结论 :Ccr水平和年龄是ARC的危险因素 ,慢性肾脏疾病患者随着Ccr下降和 (或 )年龄增加 ,ARC发病率呈上升趋势。     

卡托普利和纳多洛尔对高血压病患者肾血流动力学的影响

原发性高血压30例随机分为卡托普利(37.5-75mg/d, po, 共4wk)和纳多洛尔(40-80mg/d, po,共4wk)2组,各15例。结果:2药均使血压显著降低(P<0.01);对肾血流量和肾小球滤过率均无明显改变,但均使肾血流量/心输出量增高和肾血管阻力降低(P<0.01,P<0.05)。提示2药可能通过直接扩张肾血管而维持肾循环,有益于高血压病的长期治疗。     

不同形式补铁对尿毒症血液透析患者生活质量的影响

尿毒症是常见的慢性病.随着肾脏替代疗法的发展,尿毒症患者的生存时间已明显延长,但生活质量却仍然很低.近年,给尿毒症血液透析患者静脉补铁已成为国外研究的热点,借鉴他们的经验,我们给一部分尿毒症血透患者进行了静脉补铁,并从贫血、缺铁的改善和生活质量的提高两个方面对其疗效作了客观评价.国内迄今鲜见类似报道.本文着重介绍两种不同形式补铁对生活质量的影响.     

苦芺的本草考证

目的:通过对中药苦芺的植物形态、生境、分布、使用进行考证,为苦芺正本清源。方法:查阅汉至明清时期的辞书及历代中草药书籍,对苦芺进行植物形态、生境、分布、使用溯源考证。结果:我国中草药书籍中苦芺的基源植物较混乱,分别有为地胆草、绿蓟、蒙山莴苣、白花败酱草之说。结论:通过查阅《中国植物志》及《浙江植物志》中绿蓟地域分布和植物形态特征及其化学成分及药理作用,并结合上述古籍文献及历代中草药书籍中苦芺的本草学内容进行比对分析,苦芺的基源植物应该为绿蓟较妥。     

Significance and Expression of Serum and Glucocorticoid-inducible Kinase in Kidney of Mice with Diabetic Nephropathy

To investigate the expression and the role of three isoforms of Serum and Glucocorticoidinducible Kinase (SGK) in experimental diabetic nephropathy (DN), 12 male C57BL/6 mice of 8-weeks-old were divided into two groups. Streptozotocin (STZ)-induced diabetic nephropathy and normal controls were analyzed at the end of the 4th week after the induction of diabetes. Renal hemodynamics and histological studies were performed. The expression of SGK1 mRNA, SGK2 mRNA and SGK3 mRNA of kidney cortex were measured by RT-PCR, and the cortical SGK1 protein was detected with Western blotting. Our results showed that the blood glucose, blood HbA1c, 24h urinary protein, creatinine clearance and the renal index were all increased in DN group. More extracellular matrix (ECM) accumulation was observed. The level of cortical SGK1 mRNA and protein were up-regulated in DN group in comparison with control group. SGK2 and SGK3 mRNA were elevated in DN mice. In DN, mRNA level of three SGK isoforms and SGK1 protein were increased significantly. It is concluded that SGKs may contribute to the early renal injury of DN.     

Effect of Lipo-prostaglandin E_1 on Mesangial Proliferative Glomerulonephritis in Rats

Prostaglandin E1is a potent vasodilator as wellas aninhibitor of platelet aggregation.It has a pro-tective effect on kidney.Recently,it was reportedthat prostaglandin E1also could reduce the expres-sion of collagens and di minishthe number of prolif-erating glomerular resident cells[1].Large doses ofprostaglandin E1have to be administered intrave-nously by continuous infusion because it is rapidlyinactive inthe lung.Andit also causesirritationinblood vessels near the site of injection.Now wi…     

CD2相关蛋白在足细胞分化中的作用

为研究肾脏足细胞的分化特点及CD2相关蛋白（CD2-associated protein,CD2AP）在足细胞分化过程中的作用。采用RP—MI1640培养液在33C许可条件下培养永生化小鼠足细胞系（未分化组）．转染针对CD2AP的小分子干扰RNA（small interfering RNA．siRNA）后置于37C非许可条件下培养（转染组）,并将非许可条件下未转染组作为对照组。用MTT、法检测足细胞的生K速度;用RT—H、R方法检测CD2AP、WTI、synaptopodin和ncphrin mRNA表达;用Western blot检测CD2AP、     

肾动态显像与IgA肾病病理学改变相关性研究

目的:研究肾动态显像与IgA肾病(IgAN)病理学改变的关系。方法:选择经病理学证实为IgAN患者67例,对其肾小球、肾小管间质和血管损害程度进行Katafuchi’s积分和Lee氏分级。全部患者均接受99mTc-DTPA肾动态显像,计算出灌注指数(PI)、肾小球滤过率(GFR)和20min清除率(C20)。分析不同病理分级之间显像指标与病理积分间的关系。结果:PI与血管损害积分正相关(P<0.01),GFR与肾小球损害(P<0.01)及肾小管间质损害积分(P<0.05)负相关,C20与肾小管间质损害积分(P<0.05)负相关。随着病理分级增高,GFR和C20值逐渐降低,PI值逐渐增高,且各级之间显像参数均有显著性差异(P<0.05)。结论:肾动态显像结果与肾脏组织病理学改变明显相关,能较好地反映病理损伤的进程,对IgAN病情评价及预后判断具有实用价值。     

替加环素致血小板减少1例

患者,女,82岁,因1个月前外院行阑尾切除术,后继发切口感染,予换药处理,1周前出现阵发性腹痛,逐渐加重伴肛门少量排气、排便,2017年12月11日,门诊行相关检查后拟"不全肠梗阻、阑尾术后切口感染"收治入院,病程中无高热、畏寒。无呕血黑便,无意识障碍,无咳嗽、咯痰,纳差,尿量偏少,入院后完善相关检查,排除手术禁忌,于12月12日全麻下行剖腹探查+肠粘连松解+脾切除术+十二指肠球部溃瘍穿孔修补术+胃造口术+腹腔引流置管术,患者病情危重,术后入住ICU,诊断为消化道溃疡穿孔、脓毒症及脓毒症休克,积极对症处理,机械通气。