不同形式补铁对尿毒症血液透析患者生活质量的影响

尿毒症是常见的慢性病。随着肾脏替代疗法的发展 ,尿毒症患者的生存时间已明显延长 ,但生活质量却仍然很低。近年 ,给尿毒症血液透析患者静脉补铁已成为国外研究的热点 ,借鉴他们的经验 ,我们给一部分尿毒症血透患者进行了静脉补铁 ,并从贫血、缺铁的改善和生活质量的提高两个方面对其疗效作了客观评价。国内迄今鲜见类似报道。本文着重介绍两种不同形式补铁对生活质量的影响。材料与方法一、病例选择1 .入选标准　从本中心 98名维持性血液透析 (ｈｅｍｏｄｉａｌｙ ｓｉｓ,ＨＤ)患者中选取符合下述条件的病例 :(1 )规律ＨＤ至少稳定 3个月 …     

The Factors Related to Fungal Peritonitis in Patients on Peritoneal Dialysis

Withtheimprovementofperitonealdialysis(PD)techniqueinrecentyears,theincidenceofbacterialperitonitis(BP)hasbeen'dramaticallydecreased.However,fun-galperitonitis(FP)anditsprophylaxisandtreatmentremainproblemsandlittleprogresshasbeenmade.Wereviewedl1FPcasesamong64PDpatientswithBPinourdepartmentbetweenl985andl995,inordertodeterminewhetheraprofileofpa-tientsatriskofdevelopingFPcouldbei-dentifiedandtoevaluatetheeffectivenessofroutinetreatmentprotocolofFP.lPAT1ENrsANDMETHoDSThesubjectsinc…     

血管内皮生长因子在阿霉素肾病大鼠中的表达及其意义

血管内皮生长因子(VEGF)具有增加血管通透性和促进新生血管形成的作用。但病理状态下它的生物学功能及在肾小球疾病发生发展中的作用尚不明确。我们观察了阿霉素肾病(ADR)大鼠血清、肾组织VEGF的表达及与尿蛋白的关系,以探讨VEGF在ADR发病中的意义。 一、材料与方法 1.实验动物与分组:SD雄性健康大鼠30只,体重180-220 g,随机分为3组:(1)A组:正常对照组(n=10),大鼠     

The Effect of Connective Tissue Growth Factor on Human Renal Tubular Epithelial Cell Transdifferentiation

Summary To investigate the role of connective tissue growth factor (CTGF) in transdifferentiation of human renal tubular epithelial cell (HKC),in vitro cultured HKC cells were divided into 3 groups: negtive control, low dose CTGF-treated group (rh CTGF, 2.5 ng/ml) and high dose CTGF-treated (rhCTGF, 5. 0 ng/ml). Then the expression of α-smooth muscle actin (α-SMA) were assessed by indirect immuno-fluorescence, and the percentage of α-SMA positive cells were assessed by flow cytometry. RT-PCR were also performed to examine the mRNA level of α-SMA. Upon the stimulation of different concentrations of rhCTGF, the expression of α-SMA were markedly stronger than that in negative controls. The percentages of α-SMA positive cells were significantly higher in the stimulated groups than that of negative controls (38.9%, 65.5% vs 2.4%,P<0.01). α-SMA mRNA levels were also up-regulated by the stimulation of rhCTGF (P<0.01). These results suggest that CTGF can promote the transdifferentiation of human renal tubular epithelial cells towards myofibroblast (Myo-F). ZHANG Chun, male, born in 1977, M. D., Ph. D. This work was supported by a grant from the Science & Technology Foundation of Hubei Province (No. 2003AA301C14).     

Effect of Two Different Iron Supplementation on the Quality of Life of Uremic Hemodialysis Patients

UREMIC RENAL FAILURE is a common chronicdisease. Hemodialysis therapy has increased thelifespan of uremic patients significantly. Patientquality of life (QL), however, is also an importantindicator of the effectiveness of the medical carethat patients receive and therapies that prolonglifespan may actually compromise quality of life.1In recent years, intravenous iron has been studiedas an adjunctive therapy for anemia in hemodialysispatients. Based on protocols published previously,we selected hemodialysis ...     

茑萝松的生药学研究

目的：为茑萝松质量标准的制定及开发利用提供依据。方法：采用生药学的方法对茑萝松原植物形态特征药材性状和显微鉴别及紫外光谱进行观察研究。结果：首次系统阐明了茑萝松的生药学特性。结论：为茑萝松的准确鉴别和质量控制提供了科学的依据和生药学资料。     

654-2、普鲁卡因、肝素联合股动脉注射治疗血管病变

35例下肢血管病变的糖尿病患者,给予654～210mg、普鲁卡因100mg、肝素50mg加生理盐水5ml股动脉注射,每日一次1,0次为一个疗程后,对前后超声数据进行统计分析。结果治疗后患者下肢麻木,疼痛及足凉等症状减轻或消失,彩色多普勒复查显示血液动力学指标明显改善,下肢动脉的内径增宽、频谱变窄及加速度/减速度比值减小（P〈0.01）。结论654-2、普鲁卡因、肝素联合股动脉注射治疗糖尿病下肢血管病变值得临床推广和应用。     

社区住院2型糖尿病患者240例慢性并发症分析

目的:分析社区住院2型糖尿病患者慢性并发症情况.方法:以张家港澳阳医院住院的2型糖尿病患者为研究对象,应用统一的调查表,按病历记录,分别收集住院患者姓名、性别、病程、年龄、糖化血红蛋白、血糖、血脂、相关病史等.结果:本组研究中社区住院的2型糖尿病患者住院患者微血管并发症以糖尿病视膜病病变具多,与病程、甘油三酯呈正相关,合并症中以高血压、高脂血症、脂肪肝占比率较大,分别为38.3%、25.4%、31.2%,合并感染2型糖尿病患者占23.3%.结论:社区住院的2型糖尿病患者需提高并发症筛查的检测水平,及早发现并发症,在控制血糖同时加强血脂控制,减少糖尿病视网膜病变的发生.     

DN患者血清Cys-C、尿mAlb和血小板GMP-140检测的临床意义

目的 探讨糖尿病肾病（diabetic nephropathy,DN）患者血清Cys-C、尿mAlb和血小板GMP-140水平的变化及临床意义.方法：应用放射免疫分析、胶乳增强免疫比浊法和生化法对32例DN患者进行了Cys-C、尿mAlb和血小板GMP-140的检测,并与35名正常健康人作比较.结果 DN患者血清Cys-C和尿液Alb及血小板GMP-140水平均非常显著地高于正常人组（P〈0.01）,且血清Cys-C水平与尿mAlb、血小板GMP-140水平呈显著正相关（r=0.5642、0.6038,P〈0.01）.结论 检测DN患者血清Cys-C、尿mAlb和血小板GMP-140水平的变化对了解病情、观察疗效和预后判断均有重要的临床价值.     

短暂性脑缺血发作两种抗血小板治疗方案的的疗效比较和分析

目的 比较阿司匹林联合氯吡格雷与阿司匹林治疗短暂性脑缺血发作(TIA)的疗效和安全性,分析两种治疗方案差异的可能原因.方法 选择该院神经内科收治的诊断明确的98例TIA患者,50例给予口服阿司匹林和氯吡格雷为治疗组,48例予口服肠溶阿司匹林为对照组,均持续6个月.结果 随访6个月,治疗组50例TIA发作在10 d内完全...