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高压氧预处理减轻大鼠脑出血后脑水肿 总被引:1,自引:0,他引:1
Objective To investigate the effects of hyperbaric oxygen preconditioning (HBOP) on brain edema, inflammatory reaction and neuronal cell apoptosis induced by experimental hemorrhage in rats. Method Eighteen male Spraque-Dawley rats, weighing 300 - 350 g,received five successive sessions of HBOP with 3 atmosphere absolute pressure and 100% O2 one hour daily for five successive days, and other eighteen rats received five successive sessions of pretreatment with one atmosphere absolute pressure, air, one hour daily for five successive days. Twenty-four hours after the final pre-conditioning, rats received an infusion of 100 μL autologous blood into the basal ganglion. Seventy-two hours later, rats were sacrificed for brain edema measurements in 12 rats of each group. The histopathological changes around the hematoma were observed microscopically, and the neuronal cell apoptosis was detected by using the terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) in six rats of each group. Data of brain water content were analyzed by using Stata 7.0 software and statistical analysis was carried out by two-tailed Student t -test. Results Compared with the control group, HBOP significantly attenuated brain edema 72 hours after intra-cerebral hemorrhage in experimental rats (81. 6± 0. 7% vs. 82. 8± 0.9%, P < 0.01). Inflammatory cell infiltration and neuronal cell apoptosis were also significantly decreased in the HBOP group. Conclusions HBOP protects the rats against brain edema formation, and quells inflammatory reaction and neuronal cell apoptosis following intra-cerebral hemorrhage in experimental rats. 相似文献
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目的研究人脑出血后,血肿周围缺血半暗带脑组织中凝血酶与脑水肿的关系及二者的变化规律。方法以脑出血患者术中需要切除的缺血半暗带脑组织为实验组,远离血肿需要内减压切除的脑组织为对照组。用ELISA法检测脑组织凝血酶含量;干-湿重法测脑组织含水量;在电镜下,观察脑组织显微结构。比较两组脑组织含水量和凝血酶含量的差异,并分析不同时间窗入院患者这两个指标的变化规律。结果实验组脑组织中凝血酶的含量明显高于对照组。实验组脑组织含水量明显高于对照组。电镜下,实验组脑水肿明显比对照组严重。结论脑出血后,血肿周围缺血半暗带中凝血酶含量明显增高,凝血酶与脑水肿密切相关。 相似文献
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目的:探讨高龄患者数字减影血管造影技术的操作要点,相关并发症及术后处理。方法32例60岁以上患者局部麻醉下经股动脉穿刺置入中长鞘,先使用灌洗导管行胸主动脉弓造影,15例用单弯导管,17例用复杂弯曲导管进行全脑血管造影。结果32例完成造影,其中24例有阳性发现,8例阴性。6例发现椎动脉开口或颈内动脉有狭窄,3例术中出现不同程度血管痉挛,1例造影术后病情加重考虑有再出血。结论高龄患者常有基础疾病,血管狭窄迂曲多见,手术风险及操作难度较大。但在规范操作的基础上,全脑血管造影术是安全的,并发症较低。 相似文献
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目的分析我院神经外科住院保守治疗或手术后患者突然发生枕骨大孔疝的原因,探讨其防范方法。方法回顾过去6年我院神经外科保守治疗或术后突然发生枕骨大孔疝患者的临床资料,分析发生的原因,探讨抢救的方法及预后情况。结果共有15例患者在住院过程中突然发生枕骨大孔疝,原因包括严重低钠血症、脑水肿、出血等。患者死亡6例,恢复良好5例,严重残疾及长期昏迷4例。结论治疗过程中注意患者的水电解质平衡,合理应用水剂,有指征的患者积极手术可以很大程度上避免枕骨大孔疝的发生。 相似文献
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