连续性半侧颅痛的神经-眼科表现

目的:本文描述了一组对消炎痛有效的连续性半侧颅痛患者一种罕见的原发性头痛综合征,用神经-眼科学检查评估患者的临床表现。设计:观察性病例研究。方法:9例年龄在29～58岁的患者具有神经-眼科方面各种症状,并存在单侧持续性头痛表现。收集每例患者的详细病史,进行眼科学和神经     

对各种程度近视眼施行激光原位角膜磨镶术的5年随访

目的:评价接受激光原位角膜磨镶术(LASIK)患者的远期屈光和视力状况。方法:本文是一项针对1998—1999年间接受LASIK手术患者的视力及屈光情况的回顾性研究。对49例各种近视屈光程度的患者纳入本研究进行随访。主要观察指标:安全性、有效性、可预测性以及稳定性,同时记录了术后并发症及屈光的偏差情况。平均术前等量球镜值为-4.85。结果:术后2个月时,67%的患眼在可矫正的±0.5D,81%的患眼在±1.0D。术后5年时,60%的患眼在可矫正的±0.5D,83%在±1.0D。88%的患眼术后2个月时视力为≥6/12,而术后5年时这一比例达到89%。51%的患者最佳镜片…     

消渴平胶囊治疗2型糖尿病的临床研究报告

目的：系统观察消渴平胶囊治疗2型糖尿病的临床疗效安全性。方法：应用消渴平胶囊治疗36例2型糖尿病患者，观察疗效及安全性指标改变情况。结果：治疗后证候积分，空腹血糖，血脂，血液流变学指标均有明显改善。自身比较有显著性差异。且未见不良反应。提示：本品不仅能改善症状，降低血糖，而且对预防和延缓糖尿病并发症有积极意义。     

29例筛窦癌的放射治疗

筛窦癌发病率低,就诊时病期晚,５年无瘤生存率为３０％～５０％。由于解剖部位的限制以及局部浸润,放射和手术均有一定难度。作者回顾性分析皇家Ｍａｒｇｒｅｔ医院１９７６～１９９４年收治的２９例浸润性筛窦癌根治性放射治疗的疗效和影响预后因素。男性２４例,女性４例,中位年龄６２岁,中位随访时间４年。常有鼻出血、鼻塞、疼痛及视力改变等。起病到确诊的平均时间为９个月。２７例吸烟,１０例从事伐木或镍的开采与提炼。　　治疗前均经临床及影像学检查。仅３例局限于筛窦,余侵犯鼻腔、蝶窦、眼眶、上颌窦、额窦及脑内等。Ｔ１…     

Activity of Angiogenesis Inhibitors in Metastatic Epithelioid Hemangioendothelioma: A Case Report

This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound paclitaxel.The treatment was well tolerated and led to the stabilization of an aggressive variant of the disease. This case report is the first one that describes the activity of the combination of chemotherapy and bevacizumab in epithelioid hemangioendothelioma.Literature describing the activity of bevacizumab and other agents(thalidomide,lenalidomide,and interferon) believed to possess anti-angiogenic activities is also reviewed.     

A PRELIMINARY STUDY OF THE INHIBITING MECHANISM OF ANISODAMINE ON RABBIT PLATELETS ACTIVATED BY E. COLI ENDOTOXIN

In this study, we observed the endotoxin induced platelet aggregation, 5-HT and beta-g releases, cellular cAMP decrease, and also the changes of morphology and membrane fluidity of platelet. These changes play an important role in septic shock, especially in disseminated intravascular coagulation (DIC) and respiratory distress syndrome (RDS). After anisodamine (654) intervention all the parameters mentioned above were improved to a certain extent. This preliminary study of the inhibiting mechanism of 654 on rabbit platelets activated by ET supports the clinical possibility of using 654 for relieving DIC and RDS.     

研反纠误探幽明晦 --《中医误诊学》读后感

误诊乃医疗活动之大忌，轻则延误病情，重则危及患者生命，产生严重后果，尽管普遍存在于中医临床各科，日日间出，但因其本身的副面影响，为医者所讳，如实报道者鲜，从事系统研究者寡，至今仍未成科。人们习惯于从正面研究诊断问题，而忽略了从反面误诊学角度研究的重要性，遂为医学研究之憾事。由福建中医学院李灿东教授主编的《中医误诊学》之问世，足以弥补此不足，通读之下，耳目一新，颇感欣慰，将感悟略作以下几点评述，挂一漏万，在所难免。     

Expression for peroxisome proliferator-activated receptor gamma in pituitary adenomas 38 cases for semi-quantitative immunohistochemical analysis

BACKGROUND:It has been reposed that peroxisome proliferator-activated receptor γ(PPAR γ)is highly expressed in lung cancer,colon cancer,and gastric cancer,as well as other tumors.OBJECTIVE:To study expression of PPAR γ in pituitary adenomas and analyze the role of PPAR γ in hormonal typing of pituitary adenomas.DESIGN,TIME AND SETTING:Semi-quantitative immunohistochemistry of pathological specimens.The experiment was conducted at the Department of Neurosurgery,Wuxi Second Hospital Affiliated to Nanjing Medical University between January 2002 and May 2005.MATERIALS:Surgical resection samples of pituitary adenomas from 38 cases(18 male and 20 female)were analyzed.Eight cases were determined to be invasive pituitary adenomas and 30 cases were non-invasive pituitary adenomas.Hormonal classification of the types of pituitary adenomas revealed somatotrophic adenomas in six cases,corticotrophic adenoma in five cases,prolactinomas in 13 cases,multi-hormone secreting adenomas in six cases,and eight cases of adenoma without altered endocrine function.Five autopsy specimens were collected dunng the same period from patients of matching age that died from unrelated diseases and were included as normal anterior pituitary controls.METHODS:Cell counts for positive immunohistochemical signals were recorded from histopathological sections.The percentage of positive cells was reported as a semi-quantitative analysis.MAIN OUTCOME MEASURES:The rate of PPAR γ positive cells in different types of adenoma was based on hormonal levels and invasiveness of pituitary tumor cells.RESULTS:All tumor biopsies were determined to express PPAR γ.T1le rate of PPAR γ-positive cells ranged between 8%-65% in the pituitary adenomas.According to hormonal type,PPAR γ expression did not vary between the groups.In addition.there was no significant difference in PPAR γ expression between the non-invasive and invasive pituitary adenomas.CONCLUSIONS:Human pituitary adenomas express PPAR γ,and this expression is unrelated to hormonal type and invasiveness.     

Isolation, culture, and purification of olfactory mucosa-derived olfactory ensheathing cells using modified differential attachment with low concentration serum

BACKGROUND:Studies have demonstrated that olfactory mucosa can promote the regeneration and formation of axonal medullary sheath of injured neurons. To date, olfactory ensheathing cells (OECs) utilized in basic and clinical research arise primarily from the olfactory bulb mucosa. However, little is known regarding culture, purification, and biological properties of OECs . OBJECTIVE: To isolate and culture OECs utilized modified, differential attachment in combination with neurotrophic factor 3 (NT3) and low...     

Acupuncture at the Huatuojiaji point affects nerve root regional interleukin-1 level in a rat model of lumbar nerve root compression

BACKGROUND:It has been shown that interleukin-1 (IL-1) may cause inflammatory reactions, which stimulate the nerve root of patients with lumbar intervertebral disc protrusion and leads to pain. Whether the clinical curative effects of acupuncture in the treatment of lumbar and leg pain are linked to an inhibition of local IL-1 secretion is unknown. OBJECTIVE: To assess the influence of acupuncture on IL-1, this study was designed to verify the effects of acupuncture at the Huatuojiaji (Extra) point on the n...