B超诊断早早孕及宫外孕声像图分析

<正> 采用阴道探头B超监测,可明显提高早早孕和早期宫外孕的诊断率,但由于目前临床使用未普及,还多采用腹部B超进行诊断。本文通过236例腹部B超检查进行声像图分析,以期提高诊断及鉴别诊断率。 资料与方法 一、对象 236例妇女系我科近两年来就诊者,年龄21～40岁,均为第1次就诊时停经<36天,尿hCG(+)临床疑有早孕者。临床表现多数无早孕反应,妇科检查子宫变化不大,部分妇女有少量阴道出血症状。 二、仪器和方法 所用B超为Aloka、SSD-620型和日立EUB-450型,探头频率3.5MHz。适度充盈膀胱,经腹部     

血清HE4、CA125联合检测鉴别盆腔肿块患者卵巢癌的诊断价值

目的:探讨新肿瘤标记物血清人附睾分泌蛋白4(HE4)和CA125联合检测鉴别妇科盆腔肿块患者卵巢癌的诊断价值。方法:将诊断为妇科盆腔肿块拟行手术的108例患者和40例健康体检妇女采用酶联免疫吸附法(ELISA法)测定HE4含量、电化学发光法测定CA125含量。结果:卵巢癌组患者血清HE4、CA125水平明显高于盆腔良性肿块组患者(良性组)及健康妇女(对照组),差异有统计学意义(P<0.05),良性组血清HE4水平与健康妇女(对照组)比较差异无统计学意义(P>0.05),而同组血清CA125水平与对照组比较差异有统计学意义(P<0.05);良性组和对照组血清HE4的阳性率均为0,而良性组血清CA125为30.1%,良性组中HE4的阳性率与同组血清CA125阳性率比较差异有统计学意义(P<0.01);HE4+CA125联合检测卵巢癌的敏感度、特异度分别为91.4%、80.5%,与单一指标检测敏感度进行比较差异有统计学意义(P<0.05)。结论:HE4是一种较理想的卵巢癌肿瘤标志物,其血清水平对妇科盆腔肿块良恶性疾病的鉴别诊断具有一定的应用价值,与CA125联合检测可以提高盆腔肿块患者中卵巢癌的鉴别诊断价值。     

L-精氨酸治疗胎鼠宫内发育迟缓及对孕鼠血浆一氧化氮和内皮素的影响

胎儿宫内发育迟缓 (IU GR)是围产期胎儿发病与死亡的主要危险因素之一。本实验通过孕鼠被动吸烟建立起胎儿宫内发育迟缓模型 ,并用一氧化氮合成前体物质 L-精氨酸治疗 ,观察其对胎仔生长发育的影响及血管活性物质一氧化氮 (NO )、内皮素 (ET)的改变 ,从而为探讨 IU GR的发病机理及治疗前景提供依据。一、材料与方法1.实验动物及分组SD系雌性大鼠 10 0只 ,体重 2 2 0～2 70 g,由河南医科大学实验动物中心提供 ,按要求雌雄 2∶ 1合笼饲养 ,次日根据阴道涂片镜检 ,发现精子作为妊娠第1天 ,依妊娠顺序分为 4组 ,每组 2 5只。对照组 :正常…     

三维超声联合子宫内膜采集器在子宫内膜癌筛查中的应用#br#

Objective?To explore the value of three-dimensional ultrasound combined with disposable endometrial cell samplers in endometrial carcinoma screening. Methods?108 women with vaginal bleeding after menopause, abnormal uterine bleeding, vaginal discharge and other suspected symptoms from Jaunary 2018 to December 2020 in The Second Affiliated Hospital of Zhengzhou University were involved. The endometrium was collected by three-dimensional ultrasound combined with endometrial cell samplers, cytology and histology performed simultaneously. Benign endometrial lesions were defined as negative, endometrial dysplasia and endometrial carcinoma as positive. Results?Among the 102 patients (excluding the successful patients who had not been brushed), 56 patients (54.90%) were pathologically diagnosed as benign lesions, 46 patients (45.10%) were diagnosed as endometrial carcinoma or atypical hyperplasia. Compared with the pathological results, the diagnostic coincidence rates of three-dimensional ultrasound, endometrial collector and combined examination were 88.24%, 93.14% and 97.06%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value of the combined examination were 96.00%, 100.00%, 100.00% and 96.43%, respectively. Conclusion?Three-dimensional ultrasound combined with disposable endometrial cell samplers has high diagnostic accuracy and is easy to operate in the screening of endometrial carcinoma, which is expected to be an ideal screening method for endometrial carcinoma.