急诊救治颅内血肿37例临床分析

无论是外伤性的还是高血压脑出血等所致的颅内血肿，往往第一就诊时间和地点都在急诊，成为急诊的常见病。我院急诊科自2002年8月至2004年5月采用不同的方法急诊救治颅内血肿37例，收到较好的效果，现报道如下。     

复合手术治疗颅内外动脉多发性狭窄一例

患者男,56岁,2014年3月因左侧肢体无力、言语不清1个月余入住首都医科大学宣武医院神经外科。患者在当地医院按脑缺血接受药物治疗,症状无改善。患者有高血压病史20年,糖尿病史10年,吸烟、饮酒史30年。在首都医科大学宣武医院体格检查:右侧鼻唇沟略浅,伸舌居中,其余脑神经功能检查无阳性体征;双足踝关节以下浅感觉减退,四肢肌张力正常,左侧肌力Ⅴ-级,左手轮替笨拙。辅助     

微管相关蛋白1轻链3在新生期大鼠惊厥后海马的表达

Objective To explore the repetitive expressions of autophagy marker protein-rnicrotubule-associ-ated protein 1 light chain 3 (LC3) in hippocampus in newborn rats with recurrent seizure and the influence of 3-methyladeine (3-MA) on LC2 expressions. Method Seventy-two 6-day-old SD rats were randomly (random nam-ber) divided into the recurrent neonatal seizure group (RS group, n = 24), the 3-MA-treated seizure group (3-MA group, n = 24) and control group (n = 24). Rats in RS group were subjected to 55 attacks of seizure induced by flurothyl in 9 successive days from the 6th postnatal day (P6). In 3-MA group, 2 μL of 3-MA was injected every day till seizure induced. Western blot analysis was used to determine LC3 protein level in hippocampus at different intervals of 1.5 h,3 h,6 h and 24 h after the last convulsion. The LC3 protein level was analyzed with Dunnett test after ANOVA. Results LC3 protein levels in RS group at the different intervals were significantly higher than those in the control group and in 3-MA group (F =4.70,5.28,8.51 and 5.89, respectively, P <0.05), and there were no significant differences in LC3 protein level between 3-MA group and control group at those intervals (P > 0.05). Conclusions The autophagy/lysosomal pathway is immediately activated after recurrent seizure evidenced by the elevated expressions of LC3 in hippocampus. The 3-MA is involved in the regulation of autophagy/ lysosomal pathway by down-regulating the expressions of LC3.     

急诊救治多发伤

我院自2002年8月急诊科由依托型转变为以外科全科医生、急诊手术室及急诊ICU为组合的自主型模式救治外科急诊病人，工作效率及重病救治成功率都大为提高，尤其是为救治严重多发伤病人，赢得了时间，提高了成功率，现报道如下。     

新生儿低血糖发生脑损伤风险的影响因素分析

目的 回顾性分析新生儿低血糖脑损伤风险的影响因素.方法 选取上海交通大学医学院苏州九龙医院2018年7月至2021年7月收治的100例低血糖新生儿的临床资料,根据是否出现脑损伤分为脑损伤组(n=12)和无脑损伤组(n=88),记录并分析患儿一般资料,经Logistic回归模型分析低血糖新生儿脑损伤发生的危险因素.结果 ...     

自噬与神经系统疾病研究进展

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome and it's involved in the cycle of matter and energy. Meanwhile autophagic cell death is a form of cell death called type-Ⅱ programmed cell death. In recent years, studies have shown that autophagy is involved in pathophysiologies of nervous system disease especially neurodegenerative diseases, ischemia-hypoxia, traumatic brain injury ,seizures.