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Twenty-four rabbits were randomly divided into two groups: indomethacin group (Group A, n=12) and control group (Group B, n=12). Rabbits in septic shock had profound hypotension, hypoxia, leukocytopenia, thrombocytopenia, increased levels of lactate and prostaniods. Indomethacin (3 mg/kg) given 10 minutes after the occurrence of shock significantly improved the 24-hour survival of animals, rapidly reversed the hypotensive state of shock, increased the arterial oxygen pressure, partly prevented the increase of blood lactate, and decreased the level of prostaniods. Preliminary clinical trials also showed that indomethacin decreased the level of prostaniods and raised the blood pressure in pediatric patients with septic shock. It is clear that further clinical study is warranted. 相似文献
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本文报道用稳定性核素~(15)N标记的甘氨酸作示踪剂,测定新生儿总体蛋白质合成与分解速度,是一种安全、可靠、灵敏的方法,适于儿科科研上的应用。应用本法测得的新生儿蛋白质合成速度分别为:3例31~33孕周早产适于胎龄儿平均为35.690±5.360g/kg/日;3例34~37孕周早产适于胎龄儿平均为15.536±3.530g/kg/日;5例足月正常新生儿平均为10.583±1.818g/kg/日。本法可作为临床上判别足月小样儿和未成熟儿的一个可靠指标。通过蛋白质合成速度的测定,能为新生儿蛋白质摄入量的制订提供科学根据。通过本实验同时能得到有关甘氨酸在体内利用率的信息。足月小样儿有明显的甘氨酸(或氨基氮)利用障碍。 相似文献
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