带血管蒂的足背岛状皮瓣修复下肢软组织缺损5例

我们于1982年6月至1984年8月行带血管的足背岛状皮瓣修复小腿、足底和跟部软组织缺损5例,效果较满意,现报告如下. 一、临床资料本组5例均为男性.年龄13～56岁.5例中,2例为胫腓骨和外踝开放性骨折后瘢痕和溃疡形     

EXPERIMENTAL STUDY OF PIGMENT GALLSTONE FORMATION AND DISSOLUTION

The bilirubin in the gall stones is identified chemically and by infrared spectroscopy and gel elec trophoresis as a polymer in structure. Its precipita- tion is closely related to the activity of B-glucuroni dase, yet it is not the sole factor in conjugated bili rubin hydrolysis resulting in bilirubin precipitation. The quantitative determination of hexoamine with modified Boas-Morgan method shows glycoprotein suggesting that the greater the amount of glycoprotein in the bile, the stronger the lithogenicity. Atomic emission and absorption spectroscopy analysis lead us to believe that any elements appearing in the plasma should also be foun.d in the bile or gallstone. The precipitation of solid substances in bile is strong Iy influenced by the alteration of Ca++ concentra tion, therefore the metal ions play an essential role in the formation of socalled insoluble components of the pigment gallstone. Dissolution tests reveal that increase of bile salt or glucuronic acid concen tration in bile can reduce bilirubin precipitation. Chelating agents deprive the metal ions of the stone, leading to breakage and partial dissolution of the stone. CDTA may be a promising drug for dissolu tion of pigment gallstones.     

40例恶性梗阻性黄疸双介入治疗

恶性梗阻性黄疸在发现时常已晚期而不能作外科根治术,而姑息性外科旁路分流手术的术后并发症及死亡率又相当高.采用介入放射学技术,经皮金属内支架内引流,不仅能缓解黄疸,改善由于梗阻性黄疸引起的各种症状,改善肝功能,且具有提高患者的生存质量,为进一步治疗创造条件的功能[1].我们自2001年6月至2003年4月对40例恶性胆道梗阻的患者进行了介入治疗,现对其方法及疗效做一总结.     

用微筛法检测首钢焦化厂飘尘中有机污染物的致突变性

本文研究用微筛法-大肠杆菌E.Coli wp2,(λ)原噬菌体诱导试验检测首钢焦化厂飘尘提取物的致突变性。 材料与方法 样品由市环保所采集并萃取。采样体积10024.0立方米。尘重7.8605克(～784微克/米~3)。用重蒸苯与甲醇(4:1 V/V)萃取12小时,浓缩干燥后,再用石     

先天性成骨不全症的临床护理附病例报告

先天性成骨不全为全身性结缔组织病，以多发性骨折，蓝巩膜，进行性耳聋为特点。该病迄今尚无特殊疗法。本文对其有关临床护理问题进行重点讨论。     

原发于眼睑皮肤恶性黑色素瘤的临床病理分析

目的 探讨原发于眼睑皮肤黑色素瘤的临床、病理及免疫组化特点.方法 回顾中山眼科中心1963年7月到2008年3月收治的12例眼睑皮肤恶性黑色素瘤患者临床资料,观察其临床病理特点并进行免疫组化分析.结果 眼睑皮肤黑色素瘤发病多发生于上睑,发病年龄平均在56.42岁,发病无性别、眼别差异.组织病理学以水平扩散型多见(7例,58.3%),其次为结节型(4例,333%),恶性雀斑(1例,8.3%).按细胞形态分型以上皮样细胞型多见,其次为混合细胞型和梭形细胞型.Breslow厚度平均1.73mm.临床分期以Ⅰ期多见.免疫组化HMB45,S-100染色均呈阳性表达.有随访资料的3例患者中2例于术后1年内死亡.结论 眼睑皮肤恶性黑色素瘤是一种预后较差的恶性肿瘤,肿瘤厚度和有丝分裂指数可作为预后相关指标.免疫组化HMB45、S-100染色有助于诊断.

Abstract：

Objective To study the clinicopathologic and immunohistochemical features of primary malignant melanomas of eyelid skin.Methods Retrospectively study of 12 cases of malignant melanoma of eyelid skin by pathological diagnosis at Zhongshan Ophthalmic Center between July 1963 and March 2008.The clinical data and histopathologic sections were reviewed and immunohistochemical stains were performed in each case.Results The upper eyelid was more frequently the site of origin.There was no gender or side prediction.Patients ranged in age from 25 to 85 years with an average of 56.42 years.The histopathologic classification of melanomas included superficial spreading melanoma (58.3%, 7 cases), nodular melanoma (33.3%,4 cases) and lentigo maligna melanoma (8.3%, 1 case).The average Breslow thickness was 1.73mm.Immunohistochemical stains showed 12 cases (100%) were positive for S-100 and HMB45.Two of three cases with fellow-up data available died of metastatic melanoma within one year.Conclusions The prognosis of primary malignant melanoma of eyelid skin is poor.Tumor thickness, mitotic rate are the most significant powerful predictors.HMB45 and S-100 are helpful for diagnosis.     

棕形额蚤在剑川山区鼠疫自然疫源地鼠疫传播中的作用

棕形额蚤(Frontopsylla spadix)系细蚤科额蚤属,活动敏捷,为广宿主寄生蚤。1953—1956年在云南鼠疫疫区各县调查期间,发现齐氏姬鼠等11种啮齿、食虫及食肉动物染带该蚤,其主要寄主为齐氏姬鼠,占体表寄生蚤百分组成的21.2。该蚤在我省主要分布在滇西、滇西北、滇东北和其它一些气温较低的地区,在剑川疫源地不同海拔高度的各生境均有出现。     

牙重度磨损伴牙列缺损颞下颌关节紊乱病的治疗

颞下颌关节紊乱病是口腔医学专业中的常见多发病之一,牙重度磨损伴牙列缺损是颞下颌关节紊乱病的重要病因。本文采用咬垫式义齿的方法,对50例患者进行治疗,取得了明显的效果。临床资料　在本院就诊的50例患者,临床诊断为结构紊乱疾病的可复性盘前移位与不可复性盘前移位,其中伴有关节疼痛20例,有关节弹响36例,张口受限12例。男性22例,女性28例。年龄在28～65岁之间。本组患者中从未进行义齿修复的20例,曾进行过可摘局部义齿修复的30例。所有患者均应用咬垫式义齿进行修复治疗。咬垫式义齿的设计是先做成稳定性咬板,即是覆盖在全牙列…     

开放性骨折24小时后创面一期缝合——附四例报告

<正> 以往认为开放性骨折受伤已超过24小时者,一般不再清创,包扎换药配合全身治疗。我们自1982年起对超过24小时的开放性骨折一律清创,共5例,疗效均满意。现将清创后1期缝合的4例报告如下。例1 男,32岁,住院号:4408428小时前被磨面机绞伤右手前臂,当即送到某县医院,经研究决定截肢。因患者拒绝截肢,创面用纱布覆盖,于85年元月23日晚转入我科。检查:右前臂尺侧远端有6×10cm~2皮肤缺如区,可见尺骨骨碎     

氢化磷脂的络合作用对水杨酸、双氯灭痛、消炎痛穿透蛇皮角质层的影响

氢化磷脂(HPL)能与水杨酸、双氯灭痛、消炎痛三种非甾体消炎药络合,可以不同比例于氯仿中搅拌几小时,氯仿液呈完全澄清,如含未络合的HPL则仍为混浊分散体。结果说明水杨酸、双氯灭痛、消炎痛与HPL分别为1:1,1:2,1:1(浓度均为50mg/10ml)时可得澄清液。由熔点、红外图谱及差示扫描热量法可显示络合物与物理混合物之不同,表明药物与HPL间发生了络合作用。双氯灭痛和消