全息康肤液的研制与应用

全息康肤液的研制与应用山东省莒县店子卫生院（２７６５２２）倪守华，刘朝霞近年来，我们应用自己研制的全息康肤液治疗头癣、手癣、足癣、体癣、花斑癣等百余例，取得较好效果，今将其方药组成、制法，用法介绍如下，供同道参考。１药物组成荆芥、防风、苦参各１５克，...     

重症中暑的急救与护理

目的探讨重症中暑的急救与护理.方法对16例重症中暑患者给予迅速降温,建立两条静脉通道,高流量给氧并保持呼吸道通畅,严密观察病情变化,加强基础护理,预防并发症等急救护理.结果16例患者中2例因抢救无效死亡外,其余痊愈出院.结论对重症中暑患者迅速降温是抢救成功的关键.同时补液、扩容、纠正水电解质的平衡也是抢救成功的重要环节.     

Clinical study of the efficacy of interferon-α therapy for HBeAg-negative chronic hepatitis B patients

Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB.     

益气养阴清热法合化疗治疗急性髓细胞白血病

目的 :探讨益气养阴清热法为基本治法配合化疗治疗急性髓细胞白血病的临床疗效。方法 :用黄芪、太子参、白术、生地、黄精、天门冬、麦门冬、白花蛇舌草、半枝莲、小蓟、蒲公英、甘草组方。配合 DA、HA、IA等联合化疗方案。部分 M3 患者应用维甲酸、亚砷酸治疗。部分患者静脉滴注榄香稀乳、参脉、丹参等辅助治疗。结果 :1 5 6例完全缓解 1 1 3例 ,完全缓解率 72 .4% ;部分缓解 2 0例 ,部分缓解率 1 2 .8% ;总缓解率 85 .3% ;3年生存率 37.2 % ,5年生存率 2 2 .1 %。 32例老年患者完全缓解率 43.8% ,明显低于其他年龄段 ( P<0 .0 1 )。应用维甲酸治疗的 1 8例 M3 完全缓解 1 5例 ,完全缓解率 83.3%。亚砷酸治疗 3例完全缓解 2例。结论 :益气养阴清热法作为中医的基本治法治疗急性髓细胞白血病符合临床实际。中西医结合治疗急性髓细胞白血病缓解率高 ,患者易于接受 ,有比较高的实用价值。其中提示老年患者治疗比较困难。     

吡格列酮二甲双胍片治疗对多囊卵巢综合征伴胰岛素抵抗相关指标的调节作用

目的:分析肥胖型多囊卵巢综合征伴胰岛素抵抗的不孕症患者接受吡格列酮二甲双胍片治疗对相关指标的调节作用.方法:共纳入84例肥胖型多囊卵巢综合征伴胰岛素抵抗的不孕症患者,选择抽签法进行分组,分为对照组(给予盐酸二甲双胍片,n=42)与试验组(给予吡格列酮二甲双胍片,n=42).连续治疗3个月后,对比分析两组的性激素水平与糖...     

胃灵冲剂对大鼠慢性萎缩性胃炎黏膜G细胞及D细胞的影响

[目的]观察胃灵冲剂对大鼠慢性萎缩性胃炎（CAG）黏膜G细胞、D细胞的影响。[方法]120只Wistar雄性大鼠随机分为5组：正常对照组、模型组、维酶素组、胃灵冲剂小剂量组、胃灵冲剂大剂量组，除正常对照组外，其他大鼠制成CAG模型，模型制作成功后，对照组仅给予0．8s％氯化钠液灌胃，其他大鼠给予不同药物，30d后全部处死。应用免疫组织化学方法观察胃窦黏膜G细胞、D细胞数量。[结果]与正常对照组比较，模型组大鼠的O细胞、D细胞明显减少，与治疗组比较差异有统计学意K（P〈0．01）。[结论]G细胞、D细胞数量减少是CAG发生的重要因素之一，胃灵冲剂对胃黏膜的损害具有保护作用，是其有效治疗CAG的作用机制之一。     

Clinical study of the efficacy of interferon-α therapy for HBeAg-negative chronic hepatitis B patients

Objective To investigate the effect of IFN-α therapy for HBeAg-negative ehronie hepatitis B(CHB). Methods 50 cases of HBeAg-negative CHB patients were selected as treated group, while 52 cases of HBeAg-positive CHB as control group. Both groups received injection of IFN-α at dose of 6 MU every other day for 48 weeks. Levels of alanine aminotransferase, viral markers levels of HBeAg, HBV DNA and the four serum fibrosis markers were analysed before and after treatment and 24 weeks after the course. Results There were 36 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment. And the rates of efficacy were 72% and 50% separately. The rate of treated group was higher than that of control group(X2 = 5.43, P <0.05). The four serum fibrosis markers of the both groups were clearly dropped after treatment (t = 2.365, P < 0.05). Conclusions The theraputie effects of IFN-α at dose of 6 MU for HBeAg-negative CHB is prior to HBeAg-positive CHB. And IFN-α also have an evident funtion on preventing or delaying hepatic fibrosis in patients with CHB.     

乳腺癌中-βcatenin、cyclinD1、c-myc表达及意义

目的探讨-βcatenin、cyclinD1、c-myc在乳腺癌中的表达及意义。方法应用免疫组化法检测119例乳腺癌,72例乳腺增生症和40例正常乳腺组织中-βcatenin、cyclinD1、c-myc的表达,并分析其与乳腺癌临床病理特征的关系。结果 40例正常乳腺组织中-βcatenin在细胞膜中强表达,cyclinD1及c-myc阴性表达。乳腺癌-βcatenin异常表达率78.15%(93/119)明显高于乳腺增生症44.44%(32/72),组间比较差异有统计学意义(P<0.01)。乳腺癌cyc linD1阳性表达率57.98%(69/119)高于乳腺增生症33.33%(24/72),组间比较差异有统计学意义(P=0.001<0.01)。乳腺癌c-myc阳性表达率56.30%(67/119)高于乳腺增生症27.78%(20/72),组间比较差异有统计学意义(P<0.01)。-βcatenin异常表达、cyclinD1的过表达与淋巴结转移相关,c-myc的过表达与肿瘤大小和淋巴结转移相关。-βcatenin的异常表达与cyclinD1的表达相关,而与c-myc的表达无关。结论β-catenin异常表达是乳腺癌发生发展过程中的重要因子,这个过程可能是通过激活cyclinD1实现的。-βcatenin异常表达和cyclinD1、c-myc过表达可作为评估乳腺癌转移预后的指标。     

扶正消瘤合剂治疗中晚期恶性肿瘤的近期疗效观察

目前，中医药治疗恶性肿瘤越来越受到广泛重视，自1995年8月-1997年12月采用自制的扶正消瘤合剂配合化疗治疗中晚期恶性肿瘤，取得了较好疗效，现报道如下。     

门诊输液致护理缺陷发生的原因及对策

对门诊输液治疗中造成护理缺陷的原因进行分析,未严格执行查对制度、规章制度,护士服务态度不佳、技术不到位、应急能力不强是发生护理缺陷的主要原因.为了减少护理缺陷发生,应加强护士的素质教育及知识技能的培训,提高护士的工作责任心及对突发事件的应急能力,护士长在日常工作中应加强各个环节质量管理.