神经母细胞瘤筛查方法—点片法、双向纸层析法

神经母细胞瘤(Neuroblastoma,NB)是儿童时期常见的恶性肿瘤,常因缺乏明显的临床症状而不能及时确诊。作者应用点片法、双向纸层析法,对患儿尿内的儿茶酚胺代谢产物——香草扁桃酸(VMA)、高香草酸(HVA)、香草乳酸(VLA)进行测定,为NB筛查、诊断提供生化依据。1 资料与方法     

ISCHEMIC PAPILLOPATHY AND CONTRACEPTIVES

In January and again in April 1985, a 30-year old woman received 150 mg injections of Depo-Provera for contraception. 3 days after the 2nd injection, she experienced blurred vision in both eyes and was diagnosed as having bilateral papilledema. Her vision improved after treatment with vitamin B1 and other drugs. But optic atrophy of the right eye and papilledema of the left eye remained. In July 1985, after an injection with Depo-Provera, her vision again worsened. The woman received no more Depo-Provera after this time. In early 1987, she was referred to Beijing's Tong Ren Hospital, where she was diagnosed as having bilateral ischemic papillopathy and optic atrophy. There have been few documented cases in medical literature of ocular complications related to use of contraceptives. In 1981, Petursson et al. reported a case of macula edema resulting from oral contraceptives. In animal studies, oral contraceptives have been linked to papilledema and retinal vein obstruction. The case reported here is the 1st to link use of Depo- Provera with ocular complications.     

光敏剂辅助的光动力治疗

0 引言 光动力疗法(photodynamic therapy,PDT)是激光技术、光纤技术、光电机械技术、药物制剂技术和现代医学技术有机结合的综合性疾病治疗新方法。近年来,随着这些相关技术的飞速进步,光动力疗法也日趋成熟,并越来越显示出旺盛的生机和活力。光敏剂的应用增加了光动力治疗的选择性(或靶向性)和疗效,较之常规的光动力疗法其优点更加突出。目前,光敏剂辅助的光动力疗法技术已经趋于成熟并逐渐商品化,三种光敏药物     

应用外携式胰岛素泵治疗Ⅰ型糖尿病1例报告

我们于1988年4月为1例I型“脆性”糖尿病患者使用体外携带式胰岛素泵治疗,病情获良好控制,现报告如下。 患者,女,45岁,体育工作者。1986年元旦,因急性胆道感染糖尿病酮症酸中毒急诊入院。当时查     

中医临床"药动学"浅论

作者从5个方面对中医的临床药动学进行了探索。1、药物在煎煮过程中的整合作用:煎煮过程中,各成分之间可能发生一系列变化,可能生成新的化合物,其作用趋势会转达向一个方向或多种方面,按照医生组方侧重而达到其治疗目的。2、药物经胃肠内吸收后的分布与作用:汤药经胃肠道吸收后,首先应该是在上述正常水液代谢过程中的参与者,同时由于汤药在胃肠内的机体二次整合作用,使整个汤剂在机体内部发     

自拟人参二苓解毒汤联合盐酸恩丹西酮注射液治疗顺铂引起恶心呕吐临床观察

[目的]探讨顺铂引起恶心呕吐的有效治疗途径。[方法]对肺癌患者64例,随机分2组。自拟人参二苓解毒汤联合盐酸恩丹西酮注射液(以下简称商品名欧贝)(B组)和单独使用欧贝(A组)对顺铂为主的静脉化疗后镇吐疗效。[结果]B组(78·13%,93·75%)较A组(59·38%,75·00%)在近期镇吐治疗(指化疗后24-48h出现恶心呕吐)有明显差异(P<0·05),并在副作用方面,如便秘,乏力症状和血三系下降有明显差异(P<0·05)。[结论]辅以自拟人参二苓解毒汤确有增效解毒功能。     

FK506-壳聚糖膜与体外培养雪旺细胞生物相容性的研究

目的 探讨FK506-壳聚糖膜片与培养的雪旺细胞生物相容性.方法 将生长状况和纯度较好的第3代雪旺细胞,分别传代接种于含有FK506-壳聚糖膜片、单纯壳聚糖膜片的培养皿中培养,以盖玻片作为对照组.计算3组雪旺细胞倍增时间、雪旺细胞纯度;用MTT法比较不同膜片上雪旺细胞的生长活力,绘制生长曲线;S-100免疫荧光染色.结果 雪旺细胞倍增时间对照组为5.9 d,单纯壳聚糖膜片及FK506-壳聚糖膜片组均为4.0 d;雪旺细胞纯度分别为80%、89%,93%;雪旺细胞增殖情况以FK506-壳聚糖组最佳,单纯壳聚糖组次之,对照组最差;各组雪旺细胞均呈S-100阳性,FK506-壳聚糖组与单纯壳聚糖组雪旺细胞排列呈典型的漩涡状或栅栏状.结论 FK506-壳聚糖膜片具有更显著的组织相容性与生物功能性,并保持了雪旺细胞的生物学特性.     

Effect of atrial pacing therapy with selective pacing algorithms on paroxysmal atrial fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia among the elderly. Its incidence increases dramatically with increasing age and decreasing left ventrieular function, peaking in subjects with overt congestive heart failure, Because of the unsatisfactory efficacy and possible serious side effects of clinically available anti-AF drugs for AF patients with sick sinus syndrome, pacing techniques have recently been applied in the treatment of AF. The cardiac pacemaker Vitatron