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31.
Justinas Januskevicius Zivile Stankeviciute Dalis Baltrunas Kstutis Maeika Aldona Beganskiene Aivaras Kareiva 《Materials》2021,14(6)
In this study, an aqueous sol-gel synthesis method and subsequent dip-coating technique were applied for the preparation of yttrium iron garnet (YIG), yttrium iron perovskite (YIP), and terbium iron perovskite (TIP) bulk and thin films. The monophasic highly crystalline different iron ferrite powders have been synthesized using this simple aqueous sol-gel process displaying the suitability of the method. In the next step, the same sol-gel solution was used for the fabrication of coatings on monocrystalline silicon (100) using a dip-coating procedure. This resulted, likely due to substrate surface influence, in all coatings having mixed phases of both garnet and perovskite. Thermogravimetric (TG) analysis of the precursor gels was carried out. All the samples were investigated by X-ray powder diffraction (XRD) analysis. The coatings were also investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM) and Mössbauer spectroscopy. Magnetic measurements were also carried out. 相似文献
32.
33.
Comparison of the ipsi‐lateral versus contra‐lateral retrograde approach of percutaneous coronary interventions in chronic total occlusions
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34.
Edita Garskaite Olov Karlsson Zivile Stankeviciute Aivaras Kareiva Dennis Jones Dick Sandberg 《RSC advances》2019,9(48):27973
The objective of this study was to explore an effect of the combined inorganic materials on the wood hardness and flame-retardancy properties in a concept of sustainable material management. Herein, the reinforcement of Scots pine (Pinus sylvestris L.) sapwood with sodium silicate and TiO2 nanoparticles via vacuum-pressure technique is reported. Pyrolysis of modified wood was studied by TG-FTIR analysis; the results showed that maximum weight loss for the modified wood was obtained at 40–50 °C lower temperatures compared to the reference untreated wood. The Gram–Schmidt profiles and spectra extracted at maxima absorption from Gram–Schmidt plots indicated chemical changes in wood–inorganic composites. SEM/EDS analysis revealed the presence of Na–O–Si solid gel within the wood-cell lumen and showed that TiO2 was homogeneously distributed within the amorphous Na–O–Si glass-forming phase to form a thin surface coating. EDS mapping further revealed the higher diffusivity of sodium into the cell wall compared to the silicon compound. The presence of amorphous sodium silicate and nano-TiO2 was additionally confirmed by XRD analysis. FTIR spectra confirmed the chemical changes in Scots pine sapwood induced by alkalization. Brinell hardness test showed that the hardness of the modified wood increased with the highest value (44% increase in hardness) obtained for 10% Na2SiO3–nTiO2 modified wood. The results showed good correlation between TG and flammability test; limiting oxygen index (LOI) values for the wood–inorganic composites increased by 9–14% compared to the untreated wood.Scots pine sapwood reinforced with Na2SiO3 and nano-TiO2 shows a potential for the exploration of a broader range of wood hardness and flame-retardancy properties in a concept of sustainable material management. 相似文献
35.
Preiksaitiene E Kasnauskiene J Ciuladaite Z Tumiene B Patsalis PC Kučinskas V 《American journal of medical genetics. Part A》2012,(5):1200-1203
The use of high-resolution microarray technology for investigation of patients with intellectual disability and/or congenital anomalies provided the unique possibility to identify new microdeletion/microduplication syndromes and discover the dosage sensitive genes, which are implicated in the manifestation of various genetic conditions. Microduplication of the 7p22.1 region, 1.7 Mb in size, has very recently been reported, representing the smallest interstitional 7p duplication, associated with specific facial features and speech delay. We report on a patient with an even smaller 7p22.1 de novo microduplication, 1 Mb in size, detected in a 14.5-year-old patient with mild intellectual disability and similar facial dysmorphism, including macrocephaly, ocular hypertelorism, low-set ears, and other features. There are 15 RefSeq genes included in this duplication. ACTB gene is a strong candidate gene for the alteration of craniofacial development. Further cases with similar duplications will contribute to the delineation of a potential new microduplication syndrome of 7p22.1. 相似文献
36.
Zivile D. B��k��ssy Carla Calderon Toledo Gustav Leoj AnnCharlotte Kristoffersson Shana R. Leopold Maria-Thereza Perez Diana Karpman 《Pediatric nephrology (Berlin, Germany)》2011,26(11):2059-2071
Enterohemorrhagic Escherichia coli (EHEC) infection leads to marked intestinal injury. Sigmoid colon obtained from two children during EHEC infection exhibited
abundant TUNEL-positive cells. To define which bacterial virulence factors contribute to intestinal injury the presence of
Shiga toxin-2 (Stx2), intimin and the type III secretion system were correlated with symptoms and intestinal damage. C3H/HeN
mice were inoculated with Stx2-producing (86-24) and non-producing (87-23) E. coli O157:H7 strains and 86-24 mutants lacking eae, encoding intimin (strain UMD619) or escN regulating the expression of type III secretion effectors (strain CVD451). Severe symptoms developed in mice inoculated with
86-24 and 87-23. Few mice inoculated with the mutant strains developed severe symptoms. Strain 86-24 exhibited higher fecal
bacterial counts, followed by 87-23, whereas strains UMD619 and CVD451 showed minimal fecal counts. More TUNEL-positive cells
were found in proximal and distal colons of mice inoculated with strain 86-24 compared with strains 87-23 and CVD451 (p ≤ 0.01) or UMD619 (p < 0.05, proximal colon, p < 0.01, distal colon). The results show that strains 86-24 and 87-23 exhibited better colonic persistence and more symptoms,
presumably due to the presence of intimin and type III secretion effectors. Extensive intestinal mucosal cell death was related
to the presence of Stx2. 相似文献
37.
TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies
Stefanie J Klug Meike Ressing Jochem Koenig Martin C Abba Theodoros Agorastos Sylvia MF Brenna Marco Ciotti BR Das Annarosa Del Mistro Aleksandra Dybikowska Anna R Giuliano Zivile Gudleviciene Ulf Gyllensten Andrea LF Haws Aslaug Helland C Simon Herrington Alan Hildesheim Olivier Humbey Sun H Jee Jae Weon Kim Maria Blettner 《The lancet oncology》2009,10(8):772-784
38.
Zivile Luksiene Danute Labeikyte Benediktas Juodka Johan Moan 《Journal of environmental pathology, toxicology and oncology》2006,25(1-2):293-306
According to our previous data, hematoporphyrin dimethyl ether (HPde) at concentrations useful for photodynamic therapy can radiosensitize aggressive Ehrlich ascite carcinoma (EAT) to 2Gy irradiation inducing total tumour growth inhibition. The aim of this study was to further investigate the possible mechanism of radiosensitization of EAT by dicarboxylic porphyrin-HPde. Our results reveal that HPde is inducing several rearrangements in the EAT cells: 1.2 x 10-6 M of the photosensitizer diminishes the number of cells in mitosis by a factor of 3, increases the number of cells in the S phase of the cell cycle, modifies the activities of antioxidant enzymes glutation S-transferase (GST) and DT-diaphorase (DTD), and eventually induces slight apoptosis. Moreover, it was shown that HPde is a ligand of peripheral benzodiazepine receptor (PBR). Named "house keeper," PBR is usually responsible for all these perturbations, which, in our case, act in concert with the following ionizing radiation, producing the interaction of two antiproliferative/destructive factors. 相似文献
39.
Our previous data indicate, that hematoporphyrin dimethyl ether (HPde) can totally inhibit the growth of aggressive Ehrlich ascite tumour, when combined with low doses (2Gy) of ionizing radiation. Taking into account these findings, it appears of particular interest to evaluate the dependence of radiosensitizing efficiency of porphyrins on tumour aggressiveness. For this purpose two experimental tumour models (aggressive murine Ehrlich ascite carcinoma, (EAT), and not-aggressive hepatoma MH-22A) were used. Moreover, radiosensitizing properties of three porphyrin-type compounds of different chemical heterogeneity were evaluated (hematoporphyrin dimethyl ether (HPde), photofrin II (PII) and hematoporphyrin derivative (HPD)). Data obtained indicate, that HPde is the most effective one in this context (HPde>PII>HPD). It is important to note, that only the aggressive EAT tumours were radiosensitized by these dyes. No signs of radiosensitization (inhibition of tumour growth, injury of tumour tissue, evaluated by histological analysis) were observed in not-aggressive MH-22A hepatoma. Moreover, it was shown, that ligands of peripheral benzodiazepine receptors (PBR) might diminish the cell growth in aggressive EAT, but not in not-aggressive MH-22A hepatoma. The mechanism of radiosensitization by porphyrins, proposed in our previous studies, was strongly confirmed by these data. Actually, dicarboxylic porphyrins, being ligands of PBR, which are highly expressed in just aggressive tumours, can inhibit tumour cell proliferation and act in concert with ionizing radiation. Thus, combination of porphyrin and ionising radiation reflects the action of two antiproliferative factors, what eventually increases the response of aggressive tumours to the low doses of ionising radiation. 相似文献
40.
Antibodies to intimin and Escherichia coli secreted proteins A and B in patients with enterohemorrhagic Escherichia coli infections 总被引:3,自引:0,他引:3
Karpman D Békássy ZD Sjögren AC Dubois MS Karmali MA Mascarenhas M Jarvis KG Gansheroff LJ O'Brien AD Arbus GS Kaper JB 《Pediatric nephrology (Berlin, Germany)》2002,17(3):201-211
Enterohemorrhagic Escherichia coli produce an attaching and effacing lesion upon adhering to the intestinal epithelium. Bacterial factors involved in this histopathology
include the intimin adhesin and E. coli secreted proteins (Esps) A and B. In this study we investigated the serum antibody responses to recombinant E. coli O157:H7 intimin, EspA, and EspB by immunoblotting. Canadian patients with O157:H7 infection (n=10), Swedish patients with O157:H7 (n=21), non-O157 (n=18), or infection from which the serotype was not available (n=3), and asymptomatic household members (n=25) were studied and compared with Canadian (n=20) and Swedish controls (n=52). In Canadian patients, IgG antibodies to intimin, EspA, and EspB were analyzed, in Swedish patients and their household
members IgA, IgG, and IgM antibodies to EspA and EspB were studied. Patients and household members mounted an antibody response
to the antigens. Significantly more patients developed an acute response to EspB compared with controls (P<0.01 Canadian patients, P<0.0001 Swedish patients). EspB IgA, IgG, and IgM had a specificity of 100%, 86%, and 86%, positive predictive value of 100%,
83%, and 81%, and sensitivity of 57%, 69%, and 63%, respectively, and appear to be an appropriate assay for the detection
of EHEC infection. In cases of hemolytic uremic syndrome or hemorrhagic colitis this assay may be useful when a fecal strain
has not been isolated, or in epidemics of non-O157 infection.
Received: 18 June 2001 / Revised: 15 November 2001 / Accepted: 18 November 2001 相似文献