138例已绝经与未绝经子宫内膜癌患者临床病理分析

目的 回顾研究已绝经与未绝经子宫内膜癌的病理分型,组织分级和手术病理分期等.方法 分析1987年1月～1996年12月上海第一妇婴保健院收治的138例子宫内膜癌患者,其中已绝经者93例,未绝经者45例.所有的病人都进行了分段诊刮,134例经过手术治疗.标本均进行了病理诊断,并根据1988年FIGO标准进行分期,所得资料用X~2Fisher’s exact test分析.结果 已绝经组与未绝经组比较,早期患者(IaG_1)比例明显偏低,分别占6%与32%.(P<0.001).G_2、G_3和非内胰腺癌的发生率是高的,分别是71%和51%(P<0.05).Ⅰc、Ⅱ、Ⅲ、Ⅳ期所占的比例较大,分别是40%和30%(P<0.001).五年生存率:已绝经组为74.2%,未绝经组91.4%,两者比较有明显意义(P<0.05).结论 已绝经子宫内膜癌患者预后较未绝经者差与临床和病理特点有关.     

低剂量粒—巨噬细胞集落刺激因子在肺癌化疗中的应用

３１例肺癌患者大剂量化疗４０例次，采用配对法分成加用低剂量粒－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）的治疗组及不加用的对照组（二组均为２０例次）。结果表明，低剂量ＧＭ－ＣＳＦ明显缩短化疗所致白细胞低下的时间：治疗组为１４．５±９．４９天，对照组为１９．４±８．８５天（Ｐ＝０．０２），同时提高白细胞下降最低值：治疗组为３．３５×１０９／Ｌ±１．３７×１０９／Ｌ，对照组为２．９×１０９／Ｌ±１．１８×１０９／Ｌ。低剂量ＧＭ－ＣＳＦ的主要不良反应为发热（８０％）及肌痛、骨痛（１０％）。结果提示：低剂量ＧＭ－ＣＳＦ能支持癌症患者的大剂量化疗及连续化疗     

榄香烯乳与高聚金葡素联合治疗恶性胸腔积液

 自1995年1月～1997年6月采用随机分组的方法，比较榄香烯乳加高聚金葡素（治疗组）与单纯高聚金葡素（对照组）治疗78例恶性胸腔积液的临床疗效。结果显示治疗组有效率87.18％，对照组有效率53.84％。两组差异非常显著（P＜0.01）。治疗组主要不良反应为食欲不振、胸痛、发热。     

细胞因子与肿瘤免疫治疗

 人们研究了在肿瘤局部分泌细胞因子的作用,结果发现细胞因子基因转导肿瘤细胞可以象疫苗-样诱导机体产生免疫反应.这个发现可能为临床治疗肿瘤,提供有效的治疗方法.     

Analysis of the p21 gene in gliomas

The p21 gene encodes a cyclin dependent kinase inhibitor protein (p21) which has a tumor suppressive activity in a variety of tumor cell lines. Since, the p21 gene is up-regulated by the p53 tumor suppressor gene, which is frequently mutated in gliomas, acting therefore in the same control pathway, it constitutes a good candidate gene to be also inactivated in these tumors. To test this hypothesis, DNAs from 81 gliomas (48 glioblastomas, 11 anaplastic astrocytomas, 10 low-grade astrocytomas, 12 oligodendrogliomas and mixed gliomas), were investigated for mutations in the p21 coding sequence by denaturant gradient gel electrophoresis followed by sequencing. All these tumors have been previously screened for p53 mutations. Three different DNA variants were identified on codon 31 (17 cases), 27 (1 case) and 117 (1 case) and shown to be also present in matching constitutional DNA, suggesting they were polymorphisms. None of the tumors demonstrated a somatic mutation. No significant correlation between the presence of a p21 variant and the p53 mutation tumor status was observed. In conclusion, mutation in the p21 gene unlikely contributes to the development of gliomas.     

白细胞介素Ⅱ联合加温化疗治疗癌性腹腔积液

１９９５年始采用随机分组方法，比较白细胞介素Ⅱ与加温顺铂、５－氟尿嘧啶联合（治疗组）及单用顺铂、５－氟尿嘧啶（对照组）腹腔内灌注治疗癌性腹腔积液４３例，结果显示：治疗组有效率为９０．９％，对照组有效率为６１．９％，Ｐ＜０．０５。生存质量方面治疗组明显提高，Ｐ＜０．０５。两组毒副反应均较轻，Ｐ＞０．０５无显著性差异，结论：白细胞介素Ⅱ与加温顺铂、５－氟尿嘧啶联合腹腔灌注治疗癌性腹腔积液，可能有协同、相加作用，是有效、简便、毒副反应小的治疗手段     

鹿角治疗乳癖症的研究Ⅰ.鹿角提取物的抗炎作用

马鹿鹿角提取物能抑制右旋糖酐和二甲苯所致急性渗出性炎症，对慢性肉芽组织增生性炎症也有明显的抑制作用，对组胺、５ＨＴ、ＰＧＥ１引起的毛细血管通透性增强有明显的抑制作用     

Analysis of essential oil from rhizoma Zingiberis by GC-MS]

Sixty-six chemical components of the essential oil from Rhizoma Zingiberis were identified. The contents of these components were determined by GC-MS. The major components were camphene, beta-phellandrene and 1,8-cineole.     

Effect of rotundine on gastric acid and pepsin activity in rats]

A test was made on the effect of rotundine on the secretion of gastric acid and pepsin activity in rats. Compared with the control group, rotundine(> or = 17.1 mg/kg) inhibited gastric acid and decreased secretion of gastric juice(P < 0.01), but had no influence on pepsin activity. There was a negative relationship between total acidity and pH of gastric juice (r = -0.9818).